DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NSD and KMT2E

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_061152.3	Gene:	KMT2E / 55904	HGNCID:	18541	Length:	1858	Species:	Homo sapiens

Alignment Length:	508	Identity:	95/508 - (18%)
Similarity:	161/508 - (31%)	Gaps:	217/508 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  1005 CVKG-----GELVCCETCPIAVHAHC-----RNIPIKTNESYICEEC------------------ 1041
            |:.|     |.::||:.|.:..|..|     ::||    ::|:||.|
Human   121 CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIP----DTYLCERCQPRNLDKERAVLLQRRKR 181

  Fly  1042 -----------ESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILK------KAHGENDFVV 1089
                       |||     .|:....:..|:..|..|   |...|.:.|      |..||.:..:
Human   182 ENMSDGDTSATESG-----DEVPVELYTAFQHTPTSI---TLTASRVSKVNDKRRKKSGEKEQHI 238

  Fly  1090 ---------------RFFGT----------HDHGWISRRRVYL--YIEGDTGDGHKTKSQLFRNY 1127
                           |..|:          .:.||.::.:.::  |.|.:.           ..|
Human   239 SKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANN-----------NQY 292

  Fly  1128 TTGVE-EASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCL- 1190
            :.||: ||.|..           :...:||.       |.:.||:           ||:|.|.|
Human   293 SEGVQREAQRIA-----------LRLGNGND-------KKEMNKS-----------DLNTNNLLF 328

  Fly  1191 --PVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREP 1253
              ||:.|                                  .:|:.::           |.:.:.
Human   329 KPPVESH----------------------------------IQKNKKI-----------LKSAKD 348

  Fly  1254 IAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFI------------IDAGPKGN 1306
            :.....:|||.|:.:...:|           :.|.||......|:            :||...||
Human   349 LPPDALIIEYRGKFMLREQF-----------EANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGN 402

  Fly  1307 LARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCS 1371
            .|||:..||.||.|.:....:....:.|::|..||..:|:|..:.:|......|..|.|
Human   403 EARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCAC------ 461

  Fly  1372 GEIGGKLKDDAVKAHAKLKQMRRAKASAVRIH----VKPKKTPKVKHISADDE 1420
                       :|.:.:...::|:..|...|:    .:.||..|.|.||.:.:
Human   462 -----------LKENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKD 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898
		PHD2_NSD	867..932	CDD:277040
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042	13/45 (29%)
		WHSC1_related	1047..1141	CDD:99899	22/127 (17%)
		AWS	1183..1233	CDD:197795	8/52 (15%)
		SET	1234..1354	CDD:214614	28/131 (21%)
KMT2E	NP_061152.3	HCFC1-binding motif (HBM). /evidence=ECO:0000269\|PubMed:23629655	63..66
		PHD_MLL5	120..163	CDD:277025	13/45 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..269		7/51 (14%)
		SET	343..452	CDD:214614	29/119 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..530		8/29 (28%)
		ARGLU	550..>605	CDD:330370
		ERM	<561..>669	CDD:330563
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..687
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..960
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1068
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1164..1561
		DUF4045	<1310..>1502	CDD:330572
		Med15	1442..>1829	CDD:312941
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1835
		Atrophin-1	<1741..1846	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030