Protein Alignment NSD and setd1a

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_021329647.2
• Gene: setd1a / 556535
• ZFINID: ZDB-GENE-080521-4
• Length: 2253
• Species: Danio rerio
• Alignment Length: 1472
• Identity: 274/1472 - (18%)
• Similarity: 450/1472 - (30%)
• Gaps: 526/1472 - (35%)

  Fly    69 GQNPVQNGAQP--AAEESELESQRQTPVQKQQQQRVSM-------VNRKRDLINLQSALSPKYIG 124
            |.||.:...|.  ||...|:::..|..:.::..:.|:.       ..::|.....|:|:.    |
Zfish  1141 GHNPCEAVVQQVLAALIEEMKNIMQRDLNRKMVENVAFGTFDEWWDRKERKAKPFQTAMR----G 1201

  Fly   125 YANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTP---------GGGGGGG 180
            .|.........:...|..||..|                      ||.|         .||..|.
Zfish  1202 VAVVREEEKKEEKTTTTMTTSNR----------------------PREPLMSLVDWAKSGGMEGF 1244

  Fly   181 GDDSANQLLS-KTYMSPIEKL-----LIKNGASSP----NSTGFEAGSEDLGI-----RPIVRKH 230
            ....|.:|.| |......::|     |.:...|:|    :...::..|.|...     |.:..:.
Zfish  1245 SLRGALRLPSFKVKRKEPQELVEGDELKRARPSTPPDEEDEDSYQGKSADAAAGRTEERRVAERG 1309

  Fly   231 VKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAP------------------- 276
            ..|:..|. ||:...|||.:.::..|..|.:.|  ||:.|:.||:.
Zfish  1310 AARRRSRA-KARKPYELDSEGEETSDGSSSEKE--DEDSDKVDESEDEALSADSDDESVSSSSSE 1371

  Fly   277 --------------------TQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVEST 321
                                .|.|::.::....|:..:..||||....:.|...||       ..
Zfish  1372 SSSSSSASSSSSDEEDEEEGEQAAESESLDTMDESTMDSVAAVDTEKDERDKASLD-------QP 1429

  Fly   322 SIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPS--------SVSIDS 378
            |:...|:.::.|||      |.|:..|:.....|.|.|....|....|:.|        ..|:.|
Zfish  1430 SVTTPEDKQEEEKS------ATPVPPSSPYPRPSSPILLLPPLKKRRKTVSFSMEESEVKPSVQS 1488

  Fly   379 AKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQV 443
            :...|  ..|. |..|..|:                |..:..:....|:.|..||     .|:.:
Zfish  1489 STASS--PSPS-PVSQASDV----------------PPSVSPVSTPTPAAPSASS-----KPVPM 1529

  Fly   444 HVRFFADNGRRNWI----KPENLLTFAGLKAFDDMR-EELRIKHGPKSAKYRQMVPKRTKVVIWR 503
            .:.|.:.....:.:    .|..:||..  .....:| :|.:...||..:.  |..|.:......:
Zfish  1530 LLPFASRPSESSALTSPASPSAILTVP--PPVRSLRPDEPKKSPGPPPSP--QTPPPKNSTKRGK 1590

  Fly   504 QAIEEAQA-----MTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNL 563
            .:.....|     :..:|. |........||:.|.|...::.|.:...:..|...|:     .:|
Zfish  1591 DSPRTPPAPVCLTVQNLPL-DHASMVKMAYEDPVPLPTTQKGRARGRPRTLSQSASA-----SHL 1649

  Fly   564 HNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRR---------KLSNGTEADTGSNSMAVT 619
            |.       |::.|..:          :.:.|:|.|.|         :|::..:.|....:....
Zfish  1650 HP-------ALEEEDED----------EEELEQRLKLREQLGVSSLLQLASAPKPDLSVLADVAL 1697

  Fly   620 PSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLA 684
            ....|..:||...|.                  |||..|.               :|.|.|.|..
Zfish  1698 KMDPEADIDSEETET------------------SDEAEEH---------------KLEEEEGDFF 1729

  Fly   685 SGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAP---SEPDRRLSEPPK 746
            :....:||                |....:.:|...:.      |.||||   :.|.::..:...
Zfish  1730 APHPRQPL----------------LDPEGLFVMQEHNY------SKTPAPQHITPPQKKTKQDST 1772

  Fly   747 TKKP-------VNRPIEEVIEDIL--QLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLH 802
            ...|       |....||||.:.|  :.::..|:..|              ||:...|..:.
Zfish  1773 VLLPADLNQHGVQEAPEEVIGEALAARAEAPELYGDL--------------DLLCDGREAAE--- 1820

  Fly   803 ADCLERKVTGAPMPKIGS-RKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNV----- 861
               .:.|...:|..:.|| .|.:.:....|..:........:.:|   :.||....|..|
Zfish  1821 ---TQTKTLSSPYKRTGSISKEVELEERGKGKNKKRSRKDKENEE---LQTSKKQKEKQVKKQKK 1879

  Fly   862 ---GEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSS 923
               .|.|..|...|:||..:.|      |:|.:...|..|..|.....:....|...:..:|..:
Zfish  1880 RKLEEFEEDVDVEQLESGELSS------STSDSGDSDFGLERSLEFEKEEVRKSERLFLQEAGLT 1938

  Fly   924 KHSARCPRHVCHTCVSDDPSGK----FQQL-------------GSSKLAKCVRCPATYHQLSKCI 971
            ..:.|.|:|...:.....||.|    |:|:             ...:|.|     :||.:|.: .
Zfish  1939 PSTQRRPKHTPESLPIPRPSYKNRSEFEQMTILYDIWNSGLDQEDMRLLK-----STYEKLLQ-D 1997

  Fly   972 PAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESY 1036
            ..||..||.|:
Zfish  1998 DHGTDWLNDTH------------------------------------------------------ 2008

  Fly  1037 ICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWIS 1101
                                     |.|..|   |.:|:...||
Zfish  2009 -------------------------WVPHTI---TNIPNPRRKK--------------------- 2024

  Fly  1102 RRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKI 1166
                      .|.||.      .|.:.||...:..:..|   .|:|:|:            |:::
Zfish  2025 ----------KTADGQ------LREHVTGCARSEGYYAI---SRKEKDV------------YLEL 2058

  Fly  1167 KTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQR 1231
            ..                      ||.....|                :|..|||   ||:..:|
Zfish  2059 DQ----------------------PVTLREIG----------------DYDTAGS---NRVLSER 2082

  Fly  1232 KSP--RL------------EVVYMNERGF---------------GLVNREPIAVGDFVIEYVGEV 1267
            :|.  ||            :::.:|:..|               ||...||||..:.||||||:.
Zfish  2083 RSEQRRLLSAIGTPAVMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQS 2147

  Fly  1268 INHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRV 1332
            |.......|.::..::...:.|...|:.|.||||...||||||:||.|.|||..:..|:....::
Zfish  2148 IRQMVADNREKRYAQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKI 2212

  Fly  1333 GIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEI 1374
            .|::.:.|.||.|:|::|.:.  :..:|..|.||.:.|.|.:
Zfish  2213 VIYSKQPIGVNEEITYDYKFP--IEENKIPCLCGTESCRGTL 2252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	18/128 (14%)
		PHD2_NSD	867..932	CDD:277040	14/64 (22%)
		PHD3_NSD	933..988	CDD:277041	15/71 (21%)
		PHD4_NSD	1001..1041	CDD:277042	0/39 (0%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	14/94 (15%)
		AWS	1183..1233	CDD:197795	10/49 (20%)
		SET_NSD	1233..1375	CDD:380950	52/171 (30%)
setd1a	XP_021329647.2	None