Protein Alignment NSD and SETD5

DIOPT Version :9

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_011532222.1
• Gene: SETD5 / 55209
• HGNCID: 25566
• Length: 1500
• Species: Homo sapiens
• Alignment Length: 1161
• Identity: 223/1161 - (19%)
• Similarity: 365/1161 - (31%)
• Gaps: 437/1161 - (37%)

  Fly    50 VEIPRD--TNNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLI 112
            :|:.||  ..||:.    .||.|:....|..|.   |..||...:|.                 :
Human     1 MEVLRDPIKKNSSE----SKPAQSGFSRGNSPL---SCPESVEASPA-----------------V 41

  Fly   113 NLQSALSPKYIG-----------YANAN---SPTPLSDSDDTIRTTRRR---------VNQAAAL 154
            |.:|..|....|           ||:.|   .|.|...:...::|...|         |.:....
Human    42 NEKSVYSTHNYGTTQRHGCRGLPYADHNYGAPPPPTPPASPPVQTIIPRSDLNGLPSPVEERCGD 106

  Fly   155 NNSSAGETL----------------------------------AHDNASPRTPGGGGGGGGDDSA 185
            :.:|.|||:                                  ..||.|          |||.||
Human   107 SPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNIS----------GGDSSA 161

  Fly   186 NQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIR---PIVRKHVKRKMKRVPKAKVTLEL 247
            .:...:. :||...|.        .:|.....|..|.:|   |..||....|.:..||.|..
Human   162 TESWDEE-LSPSTVLY--------TATQHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKI--- 214

  Fly   248 DEKNQQEVDEKSVKTEPIDEEVDRTDEAPT--------------QEAQTTAISIKSETEAEHKAA 298
              |..:|...||::.:....|....||..|              :||.|...|      |:.:.|
Human   215 --KAFREGSRKSLRMKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYS------ADVQNA 271

  Fly   299 VDVHIKQ------EDTIRLDIVN-NPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVD---- 352
            ::.|:..      :.|| ||.:| ..:...:.||..:            ..|.|...|.|.
Human   272 LEQHLHSSKEFVGKPTI-LDTINKTELACNNTVIGSQ------------MQLQLGRVTRVQKHRK 323

  Fly   353 -LKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYC-----FWPC 411
             |::..||:...|           |...:|..::..    .::|...|:.|.:.:.     |...
Human   324 ILRAARDLALDTL-----------IIEYRGKVMLRQ----QFEVNGHFFKKPYPFVLFYSKFNGV 373

  Fly   412 MVCPDPLGQIVGNMPSHPQRSSLDNANV-----PIQVHVRFFA---------------------- 449
            .:|.|  .:..||.....:||...||.|     ...:|:..:|
Human   374 EMCVD--ARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCN 436

  Fly   450 -------DNGRRN---------------WIKPENLLTF-AGLKAFDDMREELRIKHGPKSA---- 487
                   ..|.||               ...|.:|.|. |..:.....|:||.::...:::
Human   437 YKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRKELEMEQQNEASEENN 501

  Fly   488 -KYRQMVPKRTKVVIWRQAI-----------------EEAQAMTQIPYSDR-LEKFYQTYENVVT 533
             :..|.||::..|....:.:                 :|..|.::....|| :|.....:||
Human   502 DQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFEN--- 563

  Fly   534 LNRQKRKRTKYMMQDTSDV--------------------GSSLYDSTDNLHNKQGTQLLAVKRER 578
            |.::|::|.:.:.|..|||                    .|.:.:|..|:......|.:.|...|
Human   564 LEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRR 628

  Fly   579 SES--------------PFSPA-------FSPVKSKNEKRAKRRKLSNGTEADT--------GSN 614
            |..              |..|:       .|..::.:.:|.||:|.:|..:|:.        |||
Human   629 SSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSN 693

  Fly   615 SMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWS----LKQIQ 675
            |: |||::. .::|||....|              :..||..|..:..|.|:...|    .|:..
Human   694 SL-VTPTEA-GSLDSSGENRP--------------LTGSDPTVVSITGSHVNRAASKYPKTKKYL 742

  Fly   676 LRELERDLASGE---IEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPS----TTP- 732
            :.|...|.|..:   :|.||               |::.....:....:|.|.:..|    |||
Human   743 VTEWLNDKAEKQECPVECPL---------------RITTDPTVLATTLNMLPGLIHSPLICTTPK 792

  Fly   733 ------APSEPDRRLSEPPKTKKPV----------NRPIEEVIED-ILQLDS-------KYLFR- 772
                  :|..|:||       ::|:          .|.|::.:|: :.|..|       ::|::
Human   793 HYIRFGSPFIPERR-------RRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQS 850

  Fly   773 --GLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVT---------GAPMPKIGSRKALVI 826
              ..|...|||    ..:||:   .....|.....:|:.||         ..|.|..||:...:.
Human   851 NENSSSSSICK----DNADLL---SPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLA 908

  Fly   827 PPTSKSPSPDE--DHVTADAKEVVAVGTSLVCHEC----NVGEPEGCVICHQVESPAVPSTPRKE 885
            .|.|..|..:|  :..:.....|.::.|:..|:..    |:..||        .|||
Human   909 TPGSSHPGEEECRNGYSLMFSPVTSLTTASRCNTPLQFENISSPE--------SSPA-------- 957

  Fly   886 DSSSHTPIEDKLLTCSQPMCGKR-----------FHTSCCKYWPQASSSKHSARCP 930
                |.|     .:.|..:|.::           .:|:.|...|...:|.||...|
Human   958 ----HRP-----ESLSPELCHRKDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLAP 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	29/193 (15%)
		PHD2_NSD	867..932	CDD:277040	14/75 (19%)
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042
		WHSC1_related	1047..1141	CDD:99899
		AWS	1183..1233	CDD:197795
		SET	1234..1354	CDD:214614
SETD5	XP_011532222.1	SET_SETD5	305..454	CDD:380958	28/177 (16%)
		COG5644	<473..>693	CDD:227931	40/222 (18%)
		PLN02217	<1360..1467	CDD:215130

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030