DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD and NSD3

DIOPT Version :10

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_075447.1 Gene:NSD3 / 54904 HGNCID:12767 Length:1437 Species:Homo sapiens


Alignment Length:1516 Identity:402/1516 - (26%)
Similarity:619/1516 - (40%) Gaps:356/1516 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 GDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAAEESEL-ESQRQTPVQKQQQQRVSMVNRKRD 110
            |:.::.|....:|..:|..|....|            |:: |...|||.:...||.........|
Human    13 GNTIQQPPQLIDSANIRQEDAFDNN------------SDIAEDGGQTPYEATLQQGFQYPATTED 65

  Fly   111 LINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGG 175
                   |.|...||       |.|.|....:|..:..||                     .|.|
Human    66 -------LPPLTNGY-------PSSISVYETQTKYQSYNQ---------------------YPNG 95

  Fly   176 GGGGGGDDSANQLLSKT--YMSPI-----EKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKR 233
            ...|.|   |.:..|.|  |.|.|     .::|.|.....|...            |.|.:.|..
Human    96 SANGFG---AVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPP------------PSVPQTVIP 145

  Fly   234 KMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDE----EVDRTDEAPTQEAQTTAISIKSETEAE 294
            |....|:.|:.:....:|.:|:.|.|:..:.::|    |..::.....:|.:..:....|....|
Human   146 KKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEE 210

  Fly   295 HKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDL 359
            .|:.....::.|:.      |.|.|... .::|:|:: |...:|.|...|:.||          :
Human   211 RKSHKIPKLEPEEQ------NRPNERVD-TVSEKPRE-EPVLKEEAPVQPILSS----------V 257

  Fly   360 SSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGN 424
            .:|.::|.:|                       :|||||.|.||.:|.:|||||..||..::...
Human   258 PTTEVSTGVK-----------------------FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTK 299

  Fly   425 MPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREEL---RIKHGPKS 486
            :.:...|          :.||:||::...|.|:..:.:..:.|.|.::::..|.   ...|..|.
Human   300 INTRGAR----------EYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQ 354

  Fly   487 AKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKF-------------YQTYENVVTLNRQK 538
             |.|:..|:|.:.. |...|..|:...::...:|:|::             .|..::|.:....|
Human   355 -KIRKPRPQRERAQ-WDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVK 417

  Fly   539 RKR-------TKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEK 596
            :.|       |:....:..:|.||| .||:...:.|.....|   |..|.|      |||...:.
Human   418 KTRRPRSVLNTQPEQTNAGEVASSL-SSTEIRRHSQRRHTSA---EEEEPP------PVKIAWKT 472

  Fly   597 RAKRRKLSNGTEADTGS------NSMAVTPSQTETTVDSSAYENPEFRQLLSAV----------- 644
            .|.|:.|........||      |...|...:....:.::..:.....|.:.:.           
Human   473 AAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISV 537

  Fly   645 --MEYVMMNRSDEKVEKVLLSVVS------NIWSLKQIQLRELERDLASGE-------------- 687
              .:.::::..:::.||...||.|      :..|:::.|.|...|..:..|              
Human   538 RGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKE 602

  Fly   688 -IEE-PLGSSVVGRGSGVGTI----KRLSNRLMTMMVRRSMTPV-VTPSTTPAPSEPDRR-LSE- 743
             :|. |..:...|...|...|    |.|..|      .|:.|.| :|.|.....|:.|.| ||: 
Human   603 QVETVPQATVKTGLQKGASEISDSCKPLKKR------SRASTDVEMTSSAYRDTSDSDSRGLSDL 661

  Fly   744 PPKTKKPVNRP---IEEVIEDILQLDSKYLFRGL---SREPICKYCYQAGSDLVRCSRTCSSWLH 802
            .....|.|:.|   .:..:.|:..:||....||.   .::.:|:.|..:|..|:.|...|....|
Human   662 QVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFH 726

  Fly   803 ADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGC 867
            .:||                .|...|.||                      .:|.||..|: ..|
Human   727 LECL----------------GLASLPDSK----------------------FICMECKTGQ-HPC 752

  Fly   868 VICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRH 932
            ..| :|....|.                   .||...|||.:|.:|.:.:|.|.......|||:|
Human   753 FSC-KVSGKDVK-------------------RCSVGACGKFYHEACVRKFPTAIFESKGFRCPQH 797

  Fly   933 VCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAH- 996
            .|..|..:.   ...:....::.:|:|||..||....||.||:.::::..:||..|:...:::. 
Human   798 CCSACSMEK---DIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSA 859

  Fly   997 VNVLWCYICV-------------------------------------------------KGGELV 1012
            |||.:|::|.                                                 |||.|:
Human   860 VNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLL 924

  Fly  1013 CCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNI 1077
            |||:||.:.|..|.:|.:... .:.|.:|::|:...|.:|||.|..|:|||||.|..|..||.||
Human   925 CCESCPASFHPECLSIEMPEG-CWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNI 988

  Fly  1078 LKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDT--GDGHKTKSQLFRNYTTGVEEASRFLPI 1140
            ....|...||.|.|||:||:.|:.:.||:.|:|||.  .:|..:.::.|:.   .:|||::....
Human   989 QGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKK---ALEEAAKRFQE 1050

  Fly  1141 IKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFS-QNLEDLSTCNCLPVDEHPCGPEAGCL 1204
            :||:|:.::......|...||||..||.||.:..::.. .:|.::..|||.|.||:|||.|:.||
Human  1051 LKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECL 1115

  Fly  1205 NRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVIN 1269
            ||||..||:|:.|.||..|:|:.|.:|..|..|::....||:||..:..|..|:||.|||||:|:
Human  1116 NRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELID 1180

  Fly  1270 HAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGI 1334
            ..|.:.|:::...:...|:|.|.|.||.|||||||||.:|||||||.|||||||||||...|||:
Human  1181 EEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGL 1245

  Fly  1335 FAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK------DDAVKAHAKLKQMR 1393
            ||:.|||...||||||.. |.:.|.:..|.|||..|||.:|.:.|      ::....:|||||.|
Human  1246 FALCDIPAGMELTFNYNL-DCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKR 1309

  Fly  1394 RAKASAVRIHVKPKKTPKVKH 1414
            |          |.|..||..|
Human  1310 R----------KIKTEPKQMH 1320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 PWWP_NSD_rpt1 395..514 CDD:438972 34/121 (28%)
PHD2_NSD 867..932 CDD:277040 16/64 (25%)
PHD3_NSD 933..988 CDD:277041 14/54 (26%)
PHD4_NSD 1001..1041 CDD:277042 15/88 (17%)
PWWP_NSD_rpt2 1048..1143 CDD:438963 38/96 (40%)
AWS 1183..1233 CDD:197795 26/49 (53%)
SET_NSD 1233..1375 CDD:380950 74/141 (52%)
NSD3NP_075447.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..157 9/47 (19%)
KIKL. /evidence=ECO:0000269|PubMed:29567837 154..157 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..252 14/78 (18%)
PWWP domain; Pfam PF00855 264..324 25/92 (27%)
PWWP_NSD3_rpt1 268..397 CDD:438991 37/140 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..365 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..465 15/68 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..696 36/161 (22%)
TNG2 <602..746 CDD:227367 41/187 (22%)
PHD type zinc finger motif 697..738 11/56 (20%)
PHD1_NSD3 703..746 CDD:277119 15/80 (19%)
PHD type zinc finger motif 745..795 16/70 (23%)
PHD2_NSD3 751..797 CDD:277122 16/65 (25%)
PHD3_NSD3 798..850 CDD:277125 14/54 (26%)
PHD type zinc finger motif 858..945 17/86 (20%)
PHD4_NSD3 917..952 CDD:277128 13/35 (37%)
PWWP domain; Pfam PF00855 954..1013 28/58 (48%)
PWWP_NSD3_rpt2 959..1053 CDD:438994 38/96 (40%)
AWS 1104..1142 CDD:465559 21/37 (57%)
SET_NSD3 1144..1285 CDD:380989 74/141 (52%)
SET domain 1149..1255 57/105 (54%)
PHD type zinc finger motif 1317..1364 2/4 (50%)
PHD5_NSD3 1323..1365 CDD:277131
C5HCH 1364..1413 CDD:465605
Blue background indicates that the domain is not in the aligned region.

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