DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and PHF20L1

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_011515377.1 Gene:PHF20L1 / 51105 HGNCID:24280 Length:1023 Species:Homo sapiens


Alignment Length:1330 Identity:235/1330 - (17%)
Similarity:387/1330 - (29%) Gaps:529/1330 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 PRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRK 234
            |..||.....|....|...|.|.|.|.|||:            .:|.|.        :..|.:|.
Human     6 PNRPGITFEIGARLEALDYLQKWYPSRIEKI------------DYEEGK--------MLVHFERW 50

  Fly   235 MKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAV 299
            ..|..:   .:..|....:.::..:::.|.:.:|.|..|....:|.      :...|:..:..|.
Human    51 SHRYDE---WIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEV------LARWTDCRYYPAK 106

  Fly   300 DVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTAL 364
            ...|.:|.|..:...:..:....                           .:.:|:.|:.:....
Human   107 IEAINKEGTFTVQFYDGVIRCLK---------------------------RMHIKAMPEDAKGQF 144

  Fly   365 ATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSH- 428
            ...:||...:|                                 |.|.:  ||.|....:|.|. 
Human   145 LFQVKSQHPLS---------------------------------WCCPI--DPAGSCNQSMGSED 174

  Fly   429 --------------------PQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDD 473
                                |:.|:..|.:          .|...|.|.|               
Human   175 WIALVKAAAAAAAKNKTGSKPRTSANSNKD----------KDKDERKWFK--------------- 214

  Fly   474 MREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTY-ENV------ 531
                               ||.:.:......|..:.:....:|.|.  |.|...: |||      
Human   215 -------------------VPSKKEETSTCIATPDVEKKEDLPTSS--ETFVGLHVENVPKMVFP 258

  Fly   532 ---VTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVK------RERSE-----SP 582
               .||: .|||..:         |:|.......|:...|  |||.|      .|:.|     :|
Human   259 QPESTLS-NKRKNNQ---------GNSFQAKRARLNKITG--LLASKAVGVDGAEKKEDYNETAP 311

  Fly   583 -FSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTV---------------DSSA 631
             ...|.|| |.:::|:         .|||..|::....|:...:|:               |||.
Human   312 MLEQAISP-KPQSQKK---------NEADISSSANTQKPALLSSTLSSGKARSKKCKHESGDSSG 366

  Fly   632 YENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSV 696
            ...|....|            |.|.::...|::||.                        |.|||
Human   367 CIKPPKSPL------------SPELIQVEDLTLVSQ------------------------LSSSV 395

  Fly   697 VGRGSGVGTI-----------KRLSNRLMTM-MVRRSMTPVVTPSTTPAP-------SEPDRRLS 742
            :.:.|....:           :|.|.||.|: |...|:..|.:||  ||.       |..:::.|
Human   396 INKTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEKVSSPS--PATDGKVFSISSQNQQES 458

  Fly   743 EPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLE 807
            ..|:.....:.|:|: :...|.||       |||          ||::.....:.||:.: :|  
Human   459 SVPEVPDVAHLPLEK-LGPCLPLD-------LSR----------GSEVTAPVASDSSYRN-EC-- 502

  Fly   808 RKVTGAPMPKIGSRKALVIP-PTSKSPSPDEDHVTADAKEV-VAVGTSLVCHECNVGEPEGCVIC 870
                    |:.......::| |:||:        .||.:.. .|.|.|....:..:.:.......
Human   503 --------PRAEKEDTQMLPNPSSKA--------IADGRGAPAAAGISKTEKKVKLEDKSSTAFG 551

  Fly   871 HQVES--------------PAVPSTPRKEDSS---SHTPIEDKLL----TCSQPMCGKRFHTSCC 914
            .:.|.              |......:|:..|   .::..||..|    .||.|:          
Human   552 KRKEKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLERCSSPL---------- 606

  Fly   915 KYWPQASSSKHSARC-----------PRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLS 968
               .::|.|..::|.           ||.:....:|.:.......|..|.....:.....|:   
Human   607 ---TRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYN--- 665

  Fly   969 KCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYIC---VKGGELVCCETCPIAVHAHC----- 1025
                   |..::||.   ..:..:.||...::.| ||   .:.|.::.||.|....|:.|     
Human   666 -------QDFDSTNF---EESQDEDDALNEIVRC-ICEMDEENGFMIQCEECLCWQHSVCMGLLE 719

  Fly  1026 RNIPIKTNESYICEEC-------------------ESGRL-------PLYGEIVWAKFNNFRWWP 1064
            .:||    |.|||..|                   .:||:       ..|..:...|..:.....
Human   720 ESIP----EQYICYICRDPPGQRWSAKYRYDKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLL 780

  Fly  1065 AIILPPTEV------PSNILKKAHGENDFVVRFFGTHD--HGW-ISRRRVYLYIEGDTGDGHKTK 1120
            |.:...|||      ...|||..|            |.  |.| .|.:|             |.:
Human   781 ADVYGVTEVLHGLQLKIGILKNKH------------HPDLHLWACSGKR-------------KDQ 820

  Fly  1121 SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLH-PPPYVKIK--------TNKAVPPLR 1176
            .|:.    .|||:        |..:...:.|.:...:.| .||.:.:|        .:....|..
Human   821 DQII----AGVEK--------KIAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQKPQS 873

  Fly  1177 FSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLE---- 1237
            |.|:.:.|:.......|:                        ..||.|.:.|..|....|:    
Human   874 FGQDCKSLADPGSSDDDD------------------------VSSLEEEQEFHMRSKNSLQYSAK 914

  Fly  1238 ----------------VVYMNERGFGLVNREPIAVGDFVIEYVGEVINHA-----EFQRRME--Q 1279
                            .||.:::|    ..:|   ||..:::...::.|.     |...||:  :
Human   915 EHGMPEKKNPAEGNTVFVYNDKKG----TEDP---GDSHLQWQLNLLTHIENVQNEVTSRMDLIE 972

  Fly  1280 KQRDRDENYYFLGVEKDFIIDAGPKGNLAR 1309
            |:.|..|::.      ||..:..|...|||
Human   973 KEVDVLESWL------DFTGELEPPDPLAR 996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 17/137 (12%)
PHD2_NSD 867..932 CDD:277040 14/96 (15%)
PHD3_NSD 933..988 CDD:277041 7/54 (13%)
PHD4_NSD 1001..1041 CDD:277042 15/47 (32%)
WHSC1_related 1047..1141 CDD:99899 20/102 (20%)
AWS 1183..1233 CDD:197795 7/49 (14%)
SET 1234..1354 CDD:214614 20/103 (19%)
PHF20L1XP_011515377.1 MBT 3..68 CDD:302657 18/84 (21%)
TUDOR 90..135 CDD:119391 6/77 (8%)
DUF3776 214..322 CDD:289391 31/156 (20%)
PHD20L1_u1 323..388 CDD:293265 15/85 (18%)
PHD_PHF20L1 688..733 CDD:277103 16/49 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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