Protein Alignment NSD and Set8

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_650354.1
• Gene: Set8 / 41743
• FlyBaseID: FBgn0011474
• Length: 691
• Species: Drosophila melanogaster
• Alignment Length: 838
• Identity: 161/838 - (19%)
• Similarity: 278/838 - (33%)
• Gaps: 248/838 - (29%)

  Fly   593 KNEKRAKRRKLSNGTEADTGSN---SMAVTPSQTETTVDSSAYENPEFR-----------QLLSA 643
            :.::.||....|:...|.:||.   ..|:..:.....::...:.:|:.:           ||..|
  Fly     6 RRQRPAKEAASSSSGGASSGSGIPVDQALPLNVAGNLLEDQYFASPKRKDCRLMKVTQNGQLPEA 70

  Fly   644 VMEYVMMNRSDEKVEKVL---------LSVVSNIW--------SLKQIQLRELERDLASGEI--- 688
            .|   |.:..|.|..:.:         ...:.|.:        |.|.|...| :.:|.:.|:
  Fly    71 TM---MAHNKDNKAGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEE-QLNLGNQELKLD 131

  Fly   689 EEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNR 753
            :|.|...:           :|.:.::.:..::      .....|...|.|.:..:     |.::.
  Fly   132 DEELNGQI-----------KLDDEVLKLADKQ------INENLPFADEVDAKAEQ-----KLMDE 174

  Fly   754 PIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKI 818
            .:::|:|::       ||.|.||.......||...|:::..:......|.    :||| .|:..:
  Fly   175 ELQQVVEEL-------LFDGSSRASSNSPFYQHDMDVMQEIQQTPEIPHI----KKVT-EPLEGL 227

  Fly   819 GSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPR 883
            ||   |....|.:|...|....|               |..:.   :...:...|.:..:..||.
  Fly   228 GS---LADFQTHRSALRDSHSST---------------HSSST---DNIFLQEPVLTLDIDRTPT 271

  Fly   884 KEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQ 948
            |..|..        :..|..:.|..|.:                  |..|.:.|:    :|:|.|
  Fly   272 KASSIK--------INRSFELAGAVFSS------------------PPSVLNACL----NGRFNQ 306

  Fly   949 L----GSSKLAKCVRCPATYHQLSKC-------------IPAG----TQMLNTTNIICPRHNIAK 992
            :    |..:...........|..|.|             .|||    .:......|:||
  Fly   307 IVSLNGQKEALDLPHFDLDQHDSSSCDSGVACGLTANTESPAGQPRRRKPATPHRILCP------ 365

  Fly   993 ADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKF 1057
                 :.:...:.|.||........|::.....|.:|..|   .....|:|.|          :.
  Fly   366 -----SPIKTALKVTGGICKVGSADPLSPRKSPRKLPTTT---AAVAACKSRR----------RL 412

  Fly  1058 NNFR----WWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHK 1118
            |..:    :.|.:..||::      ::...::|.||......|             |||..|..:
  Fly   413 NQPKPQAPYQPQLQKPPSQ------QQQQQQDDIVVVLDDDDD-------------EGDDEDDVR 458

  Fly  1119 TKSQLFRNYTTGVEEASRFLPIIKARRQEQDMER--------QSGNK--LHPPPYVKIKT----- 1168
            .                    :|||..:.::..:        ::|.|  |.|.| ||.||
  Fly   459 A--------------------LIKAAEERENQNKAPATANSNKAGMKTMLKPAP-VKSKTKSKGP 502

  Fly  1169 NKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKS 1233
            .|..|||..:....:....:..||....         |........|:.:.   .|..:.|:| .
  Fly   503 TKGQPPLPLAATNGNREMTDFFPVRRSV---------RKTKTAVKEEWMRG---LEQAVLEER-C 554

  Fly  1234 PRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDEN-----YYFLGV 1293
            ..|:|.:...:|.|:|...|....:||:||||::|:..|...|  :|:...|||     |||...
  Fly   555 DGLQVRHFMGKGRGVVADRPFKRNEFVVEYVGDLISIGEAAER--EKRYALDENAGCYMYYFKHK 617

  Fly  1294 EKDFIIDAG-PKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNY 1350
            .:.:.|||. ..|.|.|.:|||...|..|:...:.....:.:.|..||....|||::|
  Fly   618 SQQYCIDATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972
		PHD2_NSD	867..932	CDD:277040	9/64 (14%)
		PHD3_NSD	933..988	CDD:277041	15/75 (20%)
		PHD4_NSD	1001..1041	CDD:277042	7/39 (18%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	13/98 (13%)
		AWS	1183..1233	CDD:197795	7/49 (14%)
		SET_NSD	1233..1375	CDD:380950	40/124 (32%)
Set8	NP_650354.1	SET_SETD8	539..678	CDD:380926	44/143 (31%)