DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and pps

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster

Alignment Length:	1378	Identity:	242/1378 - (17%)
Similarity:	399/1378 - (28%)	Gaps:	496/1378 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STDAHSEIEGDAAHGNVLCNSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTP------- 61
            |:|:..|...|.|:.:...:..||....:|     ||.....:.|    .|.:|...|
  Fly   337 SSDSAEEENADKAYDSEEMSEESDEFQESD-----NDRDSDMDFD----MRHSNRRNPNKRKRVR 392

  Fly    62 --VRLLDKPGQNPVQNGAQPAAEESELESQRQT--PVQKQQQQRVSMVNRK---------RDLIN 113
              ||........|:...........||:.:::.  |...|..|.:.|...|         |.|.:
  Fly   393 KVVRQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAVFALGRGLPS 457

  Fly   114 LQ-SALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNS--SAGETLAHDN-ASPRTPG 174
            .. ..:.|.:........|.|.:.::..:|  |....|...:.||  ...|.:.:.| |||:
  Fly   458 TSFLKIRPTHQSLPVKRPPLPTTPANSNVR--RMPAVQLGRIVNSPQEVKEIIINKNMASPK--- 517

  Fly   175 GGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVP 239
                 |...:.|.||.:           .|.|::.:|             |:..:|........|
  Fly   518 -----GVFTNLNTLLGE-----------DNNAATKSS-------------PVPLRHRAVMSPSTP 553

  Fly   240 KAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHK----AAVD 300
            ::..       |||        ..||...|......|::......:    :|...||    ..::
  Fly   554 RSSY-------NQQ--------MSPIVVPVPAQAHTPSKGFMPIGV----DTAQSHKLPAQIVIE 599

  Fly   301 VH-----IKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLS 360
            .|     :..|:..:||::|:.|:...:..|...:.:..:.|::...:.:..||..||..||
  Fly   600 THQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAADLDPPP--- 661

  Fly   361 STALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNM 425
                         ||:                                 |..:.|.|..|.|||.
  Fly   662 -------------VSL---------------------------------PTNIFPAPEMQGVGNA 680

  Fly   426 PSHPQRSSLDNAN-----VPIQVHVRFFADNGRR---NWIKPENLLTFAG-LKAFDDMREELRIK 481
            .:....:.:|.||     .....||....:..::   ..:|.....|..| |.|...|...:...
  Fly   681 AAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPV 745

  Fly   482 HGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMM 546
            ..|:...:..::|..:       ..|.||:||.:|.:
  Fly   746 DVPQVQAHTNLLPNAS-------LTEPAQSMTSLPIA---------------------------- 775

  Fly   547 QDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRK-------LS 604
              .|....|:..||.....|       |.|......:.|   |:::.. .|||||.       ::
  Fly   776 --CSTPSRSVAASTPPTSAK-------VVRGYGRVIYLP---PIEAPT-TRAKRRAQFPSAPGMA 827

  Fly   605 NGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIW 669
            ..:.:|.|:.|..      |:::|:|
  Fly   828 ATSSSDAGNLSFG------ESSLDAS--------------------------------------- 847

  Fly   670 SLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTP------VVTP 728
                              |.:||.:|.:...|..|:..:..|.....|.|||..|      ..:.
  Fly   848 ------------------INQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQ 894

  Fly   729 STTPAPSEPDRRLSEPPK----TKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSD 789
            :..|..||......:|.|    .::|.|                      :|..||  |     |
  Fly   895 NNDPDASESQEDDDDPNKLWCICRQPHN----------------------NRFMIC--C-----D 930

  Fly   790 LVRCSRTCSSWLHADCL-ERKVTGAPM---------PKIGSRK----------ALVIPPTSK-SP 833
            |      |..|.|..|: ..|..|..|         ||...|:          .||..||:: ..
  Fly   931 L------CEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQ 989

  Fly   834 SPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLL 898
            .|.|..|.....|:|.|                          |.||.||:.     .|:  .|.
  Fly   990 RPSETKVLTTTAEIVQV--------------------------AAPSAPRRT-----LPV--VLT 1021

  Fly   899 TCSQPM------CGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKC 957
            ..|.||      ..|:|.|....:..|...:                      |.:||.|
  Fly  1022 VASSPMRIPMAKPAKKFPTGAISHQQQQQLN----------------------FIRLGPS----- 1059

  Fly   958 VRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVH 1022
                           .|.::..|..::|      |..|..:.::|      ||....:....|:.
  Fly  1060 ---------------PGKRISETLCVVC------KRPASTSSVYC------GEECIRKYAQSAIQ 1097

  Fly  1023 AHCRNI-PIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGEND 1086
            ||.... |:..|         :|...|......||.|..:          ::..::|::|    |
  Fly  1098 AHAATKGPLPQN---------AGAQSLLNNSFDAKKNKKK----------DLFEDVLRQA----D 1139

  Fly  1087 FVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKS-QLFRNYTTGVEEASRFLPIIKARRQEQDM 1150
            .|.:         :.|..|:....|....||...| ..||.:   ::|...|..:.....|..|.
  Fly  1140 TVSK---------VERINVFERKSGRVITGHMAPSAHQFRKW---LQENPSFEVLPSGTVQSADA 1192

  Fly  1151 ER-------QSGNKLHPPPYVKIKTNKAVPPLRFS-------QNLEDLSTCNCLPV---DEHPCG 1198
            |:       ::......|..:.:.......|.:.|       |....|...:..|:   |:....
  Fly  1193 EKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTT 1257

  Fly  1199 P--EAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVI 1261
            |  :|...||:...:  ||..:.|.   .|...::...|::.....|...|    :|......|:
  Fly  1258 PTVQAPTPNRIAAGK--PEPVRIGI---RRSLREQLLARIKEAQAAEENSG----QPTTQWPTVL 1313

  Fly  1262 EYVGEVINHAEFQ 1274
            | |.:.:.:.|.:
  Fly  1314 E-VDQFVKNVELE 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	20/125 (16%)
		PHD2_NSD	867..932	CDD:277040	14/70 (20%)
		PHD3_NSD	933..988	CDD:277041	7/54 (13%)
		PHD4_NSD	1001..1041	CDD:277042	8/40 (20%)
		WHSC1_related	1047..1141	CDD:99899	18/94 (19%)
		AWS	1183..1233	CDD:197795	11/54 (20%)
		SET	1234..1354	CDD:214614	8/41 (20%)
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	40/235 (17%)
		PHD_PHF3_like	914..963	CDD:277027	16/83 (19%)
		BRK	1142..1186	CDD:197800	10/55 (18%)
		TFIIS_M	1274..1396	CDD:284835	11/60 (18%)
		SPOC	1623..1729	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030