DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and ash1

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster

Alignment Length:	1730	Identity:	338/1730 - (19%)
Similarity:	568/1730 - (32%)	Gaps:	612/1730 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NNSTPVRLLDKPGQNPVQNGAQ---------PAAEESELESQRQTPVQKQQ----QQRVSMV--- 105
            |.:...::|:.  |...::|::         .:::...::|..|..||:..    :.|:|.:
  Fly     6 NETAAAKVLET--QRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPT 68

  Fly   106 -----------NRKRDLINLQS--------ALSPKY-IGYANANSPTPLSDSDDTIRTTRRRVNQ 150
                       :||....:.:|        |:|.|. :......|.:.:|.||   :.::.:.:|
  Fly    69 LGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSD---KVSKSKKSQ 130

  Fly   151 AAALNNSSAGE--TLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMS--PIEKLLIKNGASS--- 208
            .:|.::.|..:  ...|...:||.               |||....:  ...|..:..|.||
  Fly   131 ISAFSSDSEDDLPLKVHQQRAPRV---------------LLSAIIQAAQSASKPTLDIGISSSDN 180

  Fly   209 --PNST-----GFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELD--EKNQ---QEVD----- 256
              ||..     ..|:.:||..:....||..|.  |.:|:.:.||..|  ||.|   |.|:
  Fly   181 ELPNLVQAAIKRVESDTEDTTVEGSFRKAAKD--KNLPQYQSTLLQDFMEKTQMLGQTVNAKLAE 243

  Fly   257 ------------------------EKSVKTEP--------IDEEVDRTDEAPTQEAQTTAISIKS 289
                                    :|.|.|.|        |:|..|....:.|...|:|..|.|.
  Fly   244 EKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKM 308

  Fly   290 ETE-AEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEK-----------STEELAFA 342
            :.| |....::.:....:..|.:..::..:.:|..|:...|:...:           :.|||...
  Fly   309 QNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLD 373

  Fly   343 LPLASSTEVDLK------SPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWG 401
             ||....:|:.|      |....|.|..:|:|.|    .:.:||. ..|:|.|...:|.......
  Fly   374 -PLWREIDVNKKFRLRSMSVGAASGTGASTTICS----KVLAAKS-GYVSDYGSVRHQRSSHNHN 432

  Fly   402 KVFS--------YCFWPCM------------------------------------------VCPD 416
            ..:.        |....||                                          |...
  Fly   433 SGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQ 497

  Fly   417 PLGQIVG-----------NMPSHPQRSSLDNANV-----PIQVHV---RFFADNGRRNWIKPENL 462
            .:.|:.|           ...|.|...||...:.     .|..:|   ::|...|..:...|:|.
  Fly   498 DILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNF 562

  Fly   463 LTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQT 527
            ::    |..:..:|.      |..:|....:..|.         ..|.:|.            .:
  Fly   563 IS----KMMNQRKET------PAPSKSSCKIKSRR---------SSAASMC------------SS 596

  Fly   528 YENVVTLNRQKRKRTKYMMQDTSDVGSSL----------YDS-----TDNLHNKQGTQLLAVKRE 577
            |.:.|:..|::.:|..:....:.::.|.|          ::|     .|.|....|.:.|.....
  Fly   597 YVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADAN 661

  Fly   578 RSESPFSPAFSPVK-------------SKNEKRA-KRRKLS-----------------NGTEADT 611
            :.::..: |.||.:             ||..||. |:||||                 ||:.:..
  Fly   662 KLQATLA-APSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSN 725

  Fly   612 GSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMM--NRSDEKVEKVLLSVVSNIW----- 669
            |:.......||:.   |||   :|:..:|......|::.  .|...:|......:.:..|
  Fly   726 GNTKRRHKKSQSN---DSS---SPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAA 784

  Fly   670 ---------SLKQIQLRELERDLASGE---IEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSM 722
                     |..|...|.::..|...:   :|:|  :||.|.||..      ||..:.::|..:.
  Fly   785 AAKSTASTKSQAQFNARSVKSALTPKKRHLLEQP--TSVSGAGSSA------SNSPLRIVVDNNS 841

  Fly   723 TP-----VVTPST---------------------------TPAPSEPD----------------R 739
            ..     .::||:                           :||.|.|.                .
  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLS 906

  Fly   740 RLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHAD 804
            :|:|...||..|..|:...::  ::.|:|   :.:.:..:....::.|.:|:
  Fly   907 KLNESVITKAEVESPLLSALD--IKEDTK---KEVGQRVVETLLHKTGGNLL------------- 953

  Fly   805 CLERK-----VTGAPMPKIGSRKALVIPPTS--------------------------------KS 832
             |:||     .||.|..:...||..|...|:                                .:
  Fly   954 -LKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAA 1017

  Fly   833 PSP--DEDHV--TADAKEVVAVGTSLVCHECNV--------------GEPEGCVICHQVESPAVP 879
            |:|  |.:.|  ..:|:|.....|:......:|              |.|.|....::.::.|.|
  Fly  1018 PNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAP 1082

  Fly   880 STPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSG 944
            ..|.|.:                               |:...:|...|.|:   ...:.:.|..
  Fly  1083 QPPPKSE-------------------------------PEIRPAKKRGRQPK---QPVLEEPPPT 1113

  Fly   945 KFQQLGSSKLAKCVRCPATYH-----------QLSKCIPAGTQMLNTTNIICPRHNIAKADAHVN 998
            ...|...:|:...:|.|....           :..|.:.||||              .|.:..|.
  Fly  1114 PPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQ--------------PKKEKPVQ 1164

  Fly   999 VLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWW 1063
                               |:.|......||:...|  |..|.|:.||...
  Fly  1165 -------------------PVTVEEIPPEIPVSQEE--IDAEAEAKRLDSI-------------- 1194

  Fly  1064 PAIILPPTEVPSNILKKAH--GENDFVVRFFGTHDHGWISR-------RRVYLYIEGDTGDGHKT 1119
                  |||.......::|  |..|:......:.|....:.       ::.|| :.|
  Fly  1195 ------PTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYL-VAG-------- 1244

  Fly  1120 KSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSG--NKLHPPPYV------------------ 1164
               ||.|:    .:.|...|..|..: :..:|.|.|  :.|.||||.
  Fly  1245 ---LFSNH----YKQSLMPPPAKVNK-KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIW 1301

  Fly  1165 ------KIKTNKAVPPLRFSQ------------NLE--DLSTCNCLPVDEHPCGPEAGCLNRMLF 1209
                  |:.|...||...:.:            ||.  |..||||....|..|  ...|||||::
  Fly  1302 WAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSC--LDNCLNRMVY 1364

  Fly  1210 NECNPEYCKAGSLCENRMFEQRK-SPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEF 1273
            .||:|..|.||..|.|:..::.. :|.:|.....::|:|:..:.|||.|.:::||||||:...||
  Fly  1365 TECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEF 1429

  Fly  1274 QRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIK 1338
            ::||.....: |.::|.|.::...:||....|:..||:|||||||||.|||:||.:.|:.:||.:
  Fly  1430 KQRMASIYLN-DTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKR 1493

  Fly  1339 DIPVNSELTFNYLWDDLMNNSK-KACFCGAKRCSGEIGGK 1377
            .|....|||::|.: .|.|.|: :.|.|...:|.|.||||
  Fly  1494 AIEEGEELTYDYNF-SLFNPSEGQPCRCNTPQCRGVIGGK 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	22/185 (12%)
		PHD2_NSD	867..932	CDD:277040	8/64 (13%)
		PHD3_NSD	933..988	CDD:277041	10/65 (15%)
		PHD4_NSD	1001..1041	CDD:277042	6/39 (15%)
		WHSC1_related	1047..1141	CDD:99899	15/102 (15%)
		AWS	1183..1233	CDD:197795	20/50 (40%)
		SET	1234..1354	CDD:214614	48/119 (40%)
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	20/49 (41%)
		SET	1392..1512	CDD:214614	48/121 (40%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.950