DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and upSET

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster

Alignment Length:	1563	Identity:	273/1563 - (17%)
Similarity:	494/1563 - (31%)	Gaps:	496/1563 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSTDAHSEI---EGDAAHGNVLCNSASDSL-----------TATDEVAAGNDESVATEGDDVEIP 53
            |||.|...|   ....:...:|..|.|.|:           ..|..:|||...| .:.|.::..|
  Fly    49 LSTQAQLRIMQRRMSISTRQILSASQSQSINQSQKYAVRTAAGTGALAAGAASS-GSSGQELINP 112

  Fly    54 R-----DTNNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQ----KQQQQRVSMVNRKR 109
            :     .|:.||...::|.....|..|.....:..:.|  .:|.|||    :||||
  Fly   113 QIYKIVTTDGSTSNVIIDASAAAPPHNSKLLLSNLTVL--SKQAPVQGAAGQQQQQ--------- 166

  Fly   110 DLINLQSALSPKYIGYANANS---PTPL-SDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNAS- 169
              :|...|.|..|:..:.|.:   |... |.|....:..:::.:..|.|...:.|..:|....|
  Fly   167 --LNYLGAKSLPYVSASPAKTQQQPQKFGSISAFKAQHQQQQQHPHATLQKVTLGSRVATRLQSY 229

  Fly   170 -PRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRK-HVK 232
             |.:|                |:..:.|.:...:       |:|....|    |...:::| :.|
  Fly   230 VPASP----------------SQIMVQPAQPKYV-------NATATTIG----GNAALLKKANQK 267

  Fly   233 RKMKRVPKAKVTLELDEKNQQE--VDEKSVKTEPIDEEVDRTDEAPTQE---AQTTAISIKSETE 292
            ..:|.|.......:..::.||:  :..:.:||....::..:|.:|..:.   .||||:||.:..:
  Fly   268 ITVKSVSNMSQQQQQQQQQQQQQLLQAQQLKTFITQQQQQQTYKAGAKAKFVKQTTALSIAALPQ 332

  Fly   293 AEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEK-STEELAFALPLASSTEVDLKSP 356
            .:.:.   .:.||                |:|.|..|..:.| :::.:...:.|...|::..|:.
  Fly   333 QQQQT---TYAKQ----------------SMVTTSTPAKVTKLNSKYVQQQISLPQGTQLQHKAS 378

  Fly   357 PDL---------SSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCM 412
            |::         |..|:..:||..:|
  Fly   379 PNVTGGGYLLQQSQAAVGGTIKFVNS--------------------------------------- 404

  Fly   413 VCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREE 477
                 .|.::...|...|.:...:.|....      :|| .::.:...:|:|           ::
  Fly   405 -----HGTVIQQHPQQQQATKRTHYNSSGS------SDN-EQHAVANSSLIT-----------DD 446

  Fly   478 LRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRT 542
            :.|.:|      .||..:.:..::        |:|.|..:|.: ::|:|.   ..|.:......|
  Fly   447 VMIVNG------TQMTDELSARIL--------QSMAQKSFSQQ-QRFHQV---PATGSGNMPPPT 493

  Fly   543 KYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPA-FSPVKSKNEKRAKRRKLSNG 606
            :.:..:::..|::   ::....|..|..|||..:.....|.|.| |..|
  Fly   494 QIIYSNSTSNGAA---ASSPGGNASGNMLLAHYQAAGTKPVSSASFITV---------------- 539

  Fly   607 TEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSL 671
                ||      ||..|..|..|.:..:..|....:|:..|  |:.:.....:.:.:..|...||
  Fly   540 ----TG------TPPVTVATTPSVSISSHGFASGSAAISSY--MSSATAARRQSVSAPSSRAVSL 592

  Fly   672 KQIQ-LRELERDLASGEIEEPLGSSVV------GRGSGVGTIKRL--SNRLMTMMVRRSMTPVVT 727
            ::.| .::|:.|:..|..:.|   :|:      |..|.||:...|  ||.:..:...||.:....
  Fly   593 ERKQHHQQLQHDVIGGGRKAP---TVIEYYNKHGVNSIVGSSNNLAQSNSMSNLAGPRSNSGSGF 654

  Fly   728 PSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVR 792
            .:|||.|:.| ..|:       |||.|:.   .:.....|..|.:|.|:.|
  Fly   655 ATTTPTPATP-LHLT-------PVNVPVH---VEAAPPSSPALVKGSSQPP-------------- 694

  Fly   793 CSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCH 857
                                 ..|:...::|..:.|...:.:.:|.::    :||..|  .::..
  Fly   695 ---------------------AQPQQQQQQAHPLGPNQLNANDEELYI----EEVRPV--PVLTQ 732

  Fly   858 ECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQP-----------MCGKRFHT 911
            :..:.:....:..|...|......|::....:..|  .......||           :.|.:...
  Fly   733 DLRLQQLHAIMQDHTYASQQQQQQPQQAAGDTTNP--GAAQQVQQPQQWSLGGIGVTVSGSQGTP 795

  Fly   912 SC----CKYW------PQASSSKHSARCPRHVCHTCVSD-DPSGKFQQLGSSKLAKCVRCPATYH 965
            :.    |.|:      .||....|||...........:| ||..:.:....::        |...
  Fly   796 TAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLASTDIDPGEETETAPEAE--------AEDD 852

  Fly   966 QLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHC----- 1025
            .:::||                              |.:....|.::||:.|....|..|
  Fly   853 SVTRCI------------------------------CELTHDDGYMICCDKCSAWQHVDCMGIDR 887

  Fly  1026 RNIPIKTNESYICEECESGRLPLYGEIVWAK-FNNFRWWPAIILPPTEVPSNILKKAHGENDFVV 1089
            :|||    |.|:||.|:    |...:...|: ....:....::|..|:..:.....|.|..
  Fly   888 QNIP----EEYMCELCQ----PRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTT---- 940

  Fly  1090 RFFGTHDHGWISRRRVYLYIEGDTGDG--------HKTKSQLFRNYTTGV----------EEASR 1136
                               :.|..|.|        |:..|.|...:.||.          |.:..
  Fly   941 -------------------LSGGLGSGLPMSEELQHRLASGLNGGFATGTGMSKKSKKTKENSGS 986

  Fly  1137 FLPIIKARRQEQDM---ERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLP----VDE 1194
            ...:.|.::....|   :..||:  ..|.....||:|.....:.....:..|.....|    .::
  Fly   987 TSTLKKTKKSAVGMGGEKNASGS--GTPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEK 1049

  Fly  1195 HPCGPEAGCLN--RMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGL--VNREPIA 1255
            |.........|  ..:.|..:||       ...|:...:|.|.|.....|.....|  :.::...
  Fly  1050 HAANLRQWIENYEYAVTNHYSPE-------LRARLHAIQKQPSLLQSIQNTENKALRQIQQQLST 1107

  Fly  1256 VGDF--------VIEYVG--------EVINHA---EFQRRMEQKQRDRDEN-------------- 1287
            .|..        :|.|.|        ::..||   |.:.:.....:.|.:|
  Fly  1108 AGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYL 1172

  Fly  1288 ---------------YYFLGVE-------------------------KDFIIDAGPKGNLARFMN 1312
                           |...|||                         .:..:|....||.|||:.
  Fly  1173 NSFKAHKTPGQFVFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVR 1237

  Fly  1313 HSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCG-----AKRCSG 1372
            .||.||.|.|.:.......:.|.|:..|...:|:|..:...||....:|.....     :.||:.
  Fly  1238 RSCRPNAELQHYFEKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCAC 1302

  Fly  1373 EIG 1375
            ::|
  Fly  1303 DMG 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	12/116 (10%)
		PHD2_NSD	867..932	CDD:277040	14/85 (16%)
		PHD3_NSD	933..988	CDD:277041	6/55 (11%)
		PHD4_NSD	1001..1041	CDD:277042	14/44 (32%)
		WHSC1_related	1047..1141	CDD:99899	15/112 (13%)
		AWS	1183..1233	CDD:197795	8/55 (15%)
		SET	1234..1354	CDD:214614	34/194 (18%)
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	16/76 (21%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	16/51 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030