Protein Alignment NSD and KMT5A

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_047284792.1
• Gene: KMT5A / 387893
• HGNCID: 29489
• Length: 387
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 65/318 - (20%)
• Similarity: 122/318 - (38%)
• Gaps: 69/318 - (21%)

  Fly  1080 KAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKAR 1144
            :..|||.|.            .:.::|.|:..:...|.:...| ..|..|..|...:..|:....
Human    76 RTDGENVFT------------GQSKIYSYMSPNKCSGMRFPLQ-EENSVTHHEVKCQGKPLAGIY 127

  Fly  1145 RQEQDMERQSGNKLH---PPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGC--- 1203
            |:.:: :|.:||.:.   .....|||..:..|.:.|.....:.:        |.|..|.:.|
Human   128 RKREE-KRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAA--------EPPKTPPSSCDST 183

  Fly  1204 --------LNRMLFNECNPEYCKAGSLCENR-----------------------------MFEQR 1231
                    |.:.:..:..|.....|...:||                             :.|..
Human   184 NAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESG 248

  Fly  1232 KSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDEN---YYFLGV 1293
            |...:::..::.:|.|::..:..:.||||:||.|::|...:.::|.....:|....   |||..:
Human   249 KEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYL 313

  Fly  1294 EKDFIIDAGPKGN-LARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNY 1350
            .|.:.:||..:.| |.|.:|||...||:|:...::.:..:.:.|.:||....||.::|
Human   314 SKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972
		PHD2_NSD	867..932	CDD:277040
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042
		PWWP_NSD_rpt2	1048..1143	CDD:438963	12/62 (19%)
		AWS	1183..1233	CDD:197795	10/89 (11%)
		SET_NSD	1233..1375	CDD:380950	33/122 (27%)
KMT5A	XP_047284792.1	SET_SETD8	235..374	CDD:380926	35/137 (26%)