Protein Alignment NSD and Ehmt2

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_006256016.3
• Gene: Ehmt2 / 361798
• RGDID: 1302972
• Length: 1394
• Species: Rattus norvegicus
• Alignment Length: 1352
• Identity: 274/1352 - (20%)
• Similarity: 434/1352 - (32%)
• Gaps: 441/1352 - (32%)

  Fly   297 AAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSP----- 356
            |:|.|.:..|.      .:.||.:|.: |.|||::||.....:.    |..:|:....||
  Rat   246 ASVTVTVGDEG------ADTPVGATPL-IGEEPENLEGDGGRIL----LGHATKSFPSSPSKGGA 299

  Fly   357 -PDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQ 420
             |..:..::..:.|||.||...:.:.||:....|..|                    ..|:|
  Rat   300 CPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAT--------------------AGPEP--- 341

  Fly   421 IVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMR----EELRIK 481
                    |..::......| :||      ..|:...||.|     |.....:.|    :..|:.
  Rat   342 --------PPATTAGQEGQP-KVH------RARKTMSKPSN-----GQPPVPEKRPPEVQHFRMS 386

  Fly   482 HGPKSAKYRQMVPKRTK------------------VVIWR---QAIEEAQAMTQIPYSDRLEKFY 525
            ......|....|.||.|                  |::.:   :.:||.:.:.    .|....:|
  Rat   387 DDMHLGKVTSDVAKRRKLTSGSLSEDLGSAGGSGEVILEKGEPRPLEEWETVV----GDDFSLYY 447

  Fly   526 QTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTD-------------------NLHNKQGT-- 569
            ..|.....::...:...:.:.:..|:......:..:                   |..::.|:
  Rat   448 DAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSG 512

  Fly   570 QLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAV-------------TPS 621
            :..|.|:.|.:||:.......:.:...|||..:..||..:...|..|.|             :|:
  Rat   513 RRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPN 577

  Fly   622 QTETTVDSSAYENP---EFRQLLSAVMEYVMMNRSDEKVEKVLLSVVS--------NIWSLKQIQ 675
            ....:.|:|:.|..   |...|.|..||...::|..|:.....::..|        |...||:..
  Rat   578 HAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRET 642

  Fly   676 LRELERDLASGEIEEPLGSSVVGR----GSG----VGTIK------RLSNRLMTMMVRRSMTPVV 726
            :|...| :|...:.|...:.:|..    |.|    .||..      |:::|.....|.:....|.
  Rat   643 MRPSSR-VALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVF 706

  Fly   727 TPSTTPAPSE------PDRRLSEPP-KTKKPVNRPIEEVI---EDILQLDSKYLFRGLSREPICK 781
            .|......||      |......|| .|..|...|:....   .|..|..::....|..|.|.|.
  Rat   707 CPHCGEDASEAQEVTIPRGDGGTPPVGTVAPAPPPLAHDAPGRADTSQPSARMRGHGEPRRPPCD 771

  Fly   782 YCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKE 846
            ..                   ||.::.......:|..|...|:.:||             ...:|
  Rat   772 PL-------------------ADTIDSSGPSLTLPNGGCLSAVGLPP-------------GPGRE 804

  Fly   847 VVAVGTSLVCHECNVGEPEGCVICHQVES-PAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFH 910
            .:                |..::..:.|| |:.|.:|.:.......| ....|:..|....|...
  Rat   805 AL----------------EKALVIQESESLPSPPPSPGRRKKLRFHP-RQLYLSVKQGELQKVIL 852

  Fly   911 TSCCKYWPQASSSKHSARCPRH---------VCHTCVSDDPSGKFQQLGS--SKLAKCVRCP--- 961
            .......|...|.:.|.|.|.|         :||..:         |.|:  :.:.|..|.|
  Rat   853 MLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLL---------QAGANINAVDKQQRTPLME 908

  Fly   962 ---------ATYH-QLSKCIPAGTQMLNTTNIICPRHN------------IAKADAHVN------ 998
                     |.|. ||..|:.:..:..:|    |..|.            ::.....||
  Rat   909 AVVNNHLEVARYMVQLGGCVYSKEEDGST----CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGG 969

  Fly   999 ---VLWCYICVKGGELVCCETCPIAVHAHC----------RNIPIKTNESYICEECESGRLPLYG 1050
               ::|.                 |.|.|.          .::.:..||..||
  Rat   970 WTPIIWA-----------------AEHKHIDVIRMLLTRGADVTLTDNEENIC------------ 1005

  Fly  1051 EIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHG----WISRRRVY----- 1106
             :.||.|..    .|.|   .||..|.....|..|          .||    .|:.|..|
  Rat  1006 -LHWASFTG----SAAI---AEVLLNAQCDLHAVN----------YHGDTPLHIAARESYHDCVL 1052

  Fly  1107 LYI-----------EGDTG-DGHKTKS------QLFRNYTTGVEEASRFLPIIKARRQE----QD 1149
            |::           ||||. |....:|      ||.|....||..        :|.|.|    :|
  Rat  1053 LFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGN--------RAVRTEKIICRD 1109

  Fly  1150 MERQSGN-----------KLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGC 1203
            :.|...|           :..|..|..|..|.....:...:|:..|..|.|  ||:  |. .:.|
  Rat  1110 VARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTC--VDD--CS-SSNC 1169

  Fly  1204 L-------------NRML--FN--------ECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERG 1245
            |             .|:|  ||        ||| :.|.....|:||:.:.....||::....:.|
  Rat  1170 LCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECN-QACSCWRSCKNRVVQSGIKVRLQLYRTAKMG 1233

  Fly  1246 FGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKD---FIIDAGPKGNL 1307
            :|:...:.|..|.|:.|||||:|:.||...|       .|::|.|....||   :.|||...||:
  Rat  1234 WGVRALQTIPQGTFICEYVGELISDAEADVR-------EDDSYLFDLDNKDGEVYCIDARYYGNI 1291

  Fly  1308 ARFMNHSCEPNCETQKWTVNCIH------RVGIFAIKDIPVNSELTFNY---LWDDLMNNSKKAC 1363
            :||:||.|:||....:  |..:|      |:..|:.:||....||.|:|   .||  :.:....|
  Rat  1292 SRFINHLCDPNIIPVR--VFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWD--IKSKYFTC 1352

  Fly  1364 FCGAKRCSGEIGGKLKDDAVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHI 1415
            .||:::|      |...:|:    .|:|.|.|     |:...|:..|.:..:
  Rat  1353 QCGSEKC------KHSAEAI----ALEQSRLA-----RLDPHPELLPDLSSL 1389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	21/143 (15%)
		PHD2_NSD	867..932	CDD:277040	14/65 (22%)
		PHD3_NSD	933..988	CDD:277041	14/69 (20%)
		PHD4_NSD	1001..1041	CDD:277042	8/49 (16%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	27/121 (22%)
		AWS	1183..1233	CDD:197795	19/72 (26%)
		SET_NSD	1233..1375	CDD:380950	49/153 (32%)
Ehmt2	XP_006256016.3	None