Protein Alignment NSD and set-25

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_499738.3
• Gene: set-25 / 3565129
• WormBaseID: WBGene00012802
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 926
• Identity: 172/926 - (18%)
• Similarity: 279/926 - (30%)
• Gaps: 335/926 - (36%)

  Fly   548 DTSDVGSSLYDSTDNLHNKQGTQLLAV---------KRERSES--PFSPAFSPVKSKNEKRAKRR 601
            |..|:.:: |...:...|.....|.:|         ||.||||  ...|...|   :..:|.::|
 Worm    22 DEGDIRAA-YTEDEKKENIPPISLTSVSTNGAYPGQKRRRSESVRTLKPECPP---EETQRLRQR 82

  Fly   602 KLSNGTEADTGSNSMAV-----------TPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDE 655
            :..:.|:|...|.:|.|           ..||...:..:..:|.|            |...|..:
 Worm    83 RRISATDATQSSRTMNVIEDRKPRVNRARKSQDAPSTSTCGFETP------------VGTKRKSK 135

  Fly   656 KVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRR 720
            ..:...        ..||.:||         :|:|...|..|...|..|
 Worm   136 AADSQK--------PPKQSKLR---------KIDEASTSKAVDNSSKDG---------------- 167

  Fly   721 SMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVI----------EDILQLDSKYLFRGLS 775
                  ..:|.||.::.:||.|  ..:.:||  |||.:.          ||...:..:.....::
 Worm   168 ------KKTTKPAVTQSNRRRS--GLSLRPV--PIETIFSESSGRESSTEDEADVSHQQRVEKIA 222

  Fly   776 REPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHV 840
            :.||                                           .:|:.|......|:.:.:
 Worm   223 KNPI-------------------------------------------MVVVLPLGPGNYPNNERI 244

  Fly   841 TADAKEVVAVGTSLV---CHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQ 902
            |     ||:...|.|   |:|....:..|......:..|.:|:
 Worm   245 T-----VVSTYKSRVNKNCNEARRAQRHGSWSRKGIAFPGIPT---------------------- 282

  Fly   903 PMCGKRFHTS-CCKY------WP--QASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCV 958
                |:|..| ..||      ||  .|..|:.......:...||:
 Worm   283 ----KKFTKSDLAKYGAHASNWPAQAAFRSEEGKILIYYEGWTCL-------------------- 323

  Fly   959 RCPATYHQLS--KCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAV 1021
                |.|:||  :|......:|...:|         .|..:                 ||...|.
 Worm   324 ----TLHRLSVEECARTAPTILEEMSI---------RDKFI-----------------ETVKSAA 358

  Fly  1022 HAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGEND 1086
            ....:.:..|..|:.|....:.....::.|.|                |...|.|:.
 Worm   359 AEEAKLVVEKNQENGIELTLDEALKQIFIEPV----------------PQSSPENVF-------- 399

  Fly  1087 FVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEE---ASRFLPIIKARRQEQ 1148
                        ||.:...|.:.. |..|..........:||..|..   |...:.|:.....::
 Worm   400 ------------WIYQDLSYFHTM-DNRDLGLAPVFYISSYTQSVRPPCYAYTAINIVDVDAYKR 451

  Fly  1149 DMERQ--------SGNKLHPPPYVKIKTN----KAVPPLRFSQNLEDLSTCNCLP---------- 1191
            .:|.:        :|.|:..|...|...|    |......|..:..|::...|.|
 Worm   452 CLESRANMSFADLTGQKIWMPTRSKACENGTKCKCDARFMFLYDPHDVTNLECTPDGKVDFTDFK 516

  Fly  1192 VDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMN-ERGFGLVNREPIA 1255
            :|           |..:..||: :.|.....|..|..::.:...|.|.|.. |:|||:.....|.
 Worm   517 ID-----------NARIVMECS-DACGCSLDCPRRSLQRGQQHPLAVYYEGPEKGFGVRAAANIK 569

  Fly  1256 VGDFVIEYVGEV---------------INHAEFQRRMEQKQR-DRDENYYFLGVEKDFIIDAGPK 1304
            .|:.|.||.|:|               .:..|.|...|..:| |...:..|..::...||.|...
 Worm   570 AGELVCEYTGDVTLLPTSDPVASSSTKTDDGEEQENPEAPERVDSSYDAAFNAMDTKIIISAKKT 634

  Fly  1305 GNLARFMNHSCEPN-----CETQKWTVN-CIHRVGIFAIKDIPVNSELTFNYL-----WDDLMNN 1358
            ||::||:||||:|:     ..::::..: .|.||.::|||||.:..|:|..|.     |    ..
 Worm   635 GNISRFINHSCDPSSVFVEVYSRRFEEDPLIPRVAVYAIKDIALGEEITIAYYEPGIEW----KR 695

  Fly  1359 SKKACFCGAKRCSGEI 1374
            |...|.|.:.:|.|.:
 Worm   696 SSVKCRCKSTKCMGTL 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972
		PHD2_NSD	867..932	CDD:277040	11/73 (15%)
		PHD3_NSD	933..988	CDD:277041	9/56 (16%)
		PHD4_NSD	1001..1041	CDD:277042	6/39 (15%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	15/97 (15%)
		AWS	1183..1233	CDD:197795	10/59 (17%)
		SET_NSD	1233..1375	CDD:380950	49/170 (29%)
set-25	NP_499738.3	SET	<525..711	CDD:394802	54/190 (28%)