DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and Setd2

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_038937536.1	Gene:	Setd2 / 316013	RGDID:	1305576	Length:	2543	Species:	Rattus norvegicus

Alignment Length:	1608	Identity:	338/1608 - (21%)
Similarity:	552/1608 - (34%)	Gaps:	512/1608 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AHSEIEGDAAHGNVLCNSASD-----SLTATDEVAAGN---DESVATEGDDVEIPRDTNNSTPVR 63
            ::|::|.|..:.:..|.|..|     |.:.:|.|:..:   ..|..:...|.|  |..:.|:|.|
  Rat   386 SYSKLERDTRYVSTRCRSERDRRRSRSRSRSDRVSRTSLSYSRSERSHYYDSE--RRYHRSSPYR 448

  Fly    64 LLDKPGQNPVQNGAQPAAEESELESQ------RQTPVQKQQQQRVSMVNRK--RDLINLQSALS- 119
            ...:..:....|.|:   |.|:.|.:      |:|.....:..|.|....|  ||.....|.|.
  Rat   449 ERTRYSRPYTDNRAR---ESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRDCKTETSYLEM 510

  Fly   120 -----------------------------PKYIGYANANSPTPLSDSDDTIR---TTRRRVNQAA 152
                                         |..:|:...:|.:. .|::.|.|   ...:.::::.
  Rat   511 ERRGKYSSKLERESKRTSEHEAIKRCCSPPNELGFRRGSSYSK-HDNNSTSRYKSALSKSISKSD 574

  Fly   153 ALNNSSAGETLAHDNA-----SPRTPGGGGG-------------GGGDDSANQLLSKTYMSPIEK 199
            ...||.....|..:|.     |.:||...|.             .|....:|||..    ||..|
  Rat   575 KFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKIPEREKTGSPSPSNQLND----SPTFK 635

  Fly   200 LLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAK---------VTLELDEKNQQEV 255
            .|.::....|...|.::             |...|...:||.|         :.|.::...:.|.
  Rat   636 KLDESPILKPEFIGHDS-------------HESIKELELPKMKNDQLRNFCSIELNVNGSPETET 687

  Fly   256 DEKSVKTEPIDEEVDRTDEAPTQEAQTTAI-----------SIKSETEAEHKAAVDVHIKQEDTI 309
            |..:.:|...|.....:|::.|....:..|           |:....|.:...|...|.|.:...
  Rat   688 DVATFRTSKPDAISMTSDDSVTGSEVSPLIKGCVLSSNGFQSVGRCRERDADDACRQHNKSKSPF 752

  Fly   310 RL----------DIVNNPVEST--SIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSST 362
            |.          .:::.||::.  |..:.:||.|...|         ...:.:.|....|:.||.
  Rat   753 RETEPLLSPHHDKVMSLPVKTIDYSKTLIKEPVDKRHS---------CCKTKDSDRYCSPNESSE 808

  Fly   363 ALATSIKSPS--SVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNM 425
            |....|.|..  :|.:||                               ..:||
  Rat   809 AENREISSNCFVNVHLDS-------------------------------KTVVC----------- 831

  Fly   426 PSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYR 490
                     ||..:..| |..|..|..:::    ....:.|.|..|||:.|.:    |.......
  Rat   832 ---------DNRELTDQ-HSEFTCDGYKQS----IGSTSSASLNHFDDLYESV----GSSGISSL 878

  Fly   491 QMVP------KRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDT 549
            |.:|      :.|.     .|::..|:...|.:                        .||:.::|
  Rat   879 QSLPSGIRCEENTS-----PALDTVQSKKGIDF------------------------LKYVGKET 914

  Fly   550 SDVGSSL------YDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTE 608
             ||.|:|      :.|.:|.||....|.|...:|...|          :.:|:|. |.::|...|
  Rat   915 -DVVSALPDSGKAFSSWENRHNMLSGQSLQESQEEGSS----------TLHERRG-RSEVSLDEE 967

  Fly   609 ADTG-----SNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNI 668
            ...|     .:|..|.|.....|::.|           ..|...:..:.|....|  ::|.|...
  Rat   968 EQRGHTHISDDSEVVFPYDLNLTMEDS-----------DGVTYTLKCDSSGNAPE--IVSTVHGD 1019

  Fly   669 WSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPA 733
            :|.....    ..|.:..|..|...||:.            .|||.:::|....:.:....|:|.
  Rat  1020 YSASSAS----SSDESDSEDTESDDSSIP------------RNRLQSVVVVPKNSTLPMEETSPC 1068

  Fly   734 PSEPD---RRLSEPPKTKKPVNR-PIEEVIEDIL-----QLDSKYLFRGLSREPICKYCYQAGSD 789
            .|...   |..|:..:......| ..||..|.:.     |.:..:|.:|..|.|...|..
  Rat  1069 SSRSSQSYRHYSDHWEDGLESRRHAYEEKFESMASKGCSQTEKFFLHKGTERNPETSYSQ----- 1128

  Fly   790 LVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTS----KSPS----PDEDHVTADAKE 846
                            ..||:.. .:|:|...::..:..||    ||.|    ..||.:.|
  Rat  1129 ----------------FSRKIDN-HLPEIAHSQSDGVDSTSHTDVKSDSVGHLNSEDAIRA---- 1172

  Fly   847 VVAVGTSLVCHECNVGEPEGC-VICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGK--- 907
                         .:..|:.. |.|...|.  :|:|.|::...|:.|...:|        ||
  Rat  1173 -------------KMSRPQELPVYCDDFED--LPNTSRQQMIFSNRPDSSRL--------GKAEL 1214

  Fly   908 RFHTSCCKYWPQASSSK----HSARCPRHV-CHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQL 967
            .|.:||       ..|:    ||:...|:: ......:.|:..:||..||
  Rat  1215 SFSSSC-------DISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSS--------------- 1257

  Fly   968 SKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKT 1032
                 .||         |..|...::..|.          ||           .|.:.:
  Rat  1258 -----YGT---------CGTHKYQQSAEHY----------GG-----------THDYWQ------ 1281

  Fly  1033 NESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDH 1097
            ...| .:...:||.|..| :|:.:...            :||.::......|.::..| .|:|
  Rat  1282 GNGY-WDPRSAGRPPGTG-VVYDRIQG------------QVPDSLTDDREEEENWDQR-SGSH-- 1329

  Fly  1098 GWISRRRVYLYIEGDTG-------DGHKTKSQLF----RNYTTGVEE---ASRFLPIIKARRQEQ 1148
             :.|....:.:.:.|.|       ..:..|..|.    ::::...|:   ..|..|  |.||||.
  Rat  1330 -FSSPSNKFFFHQKDKGSVQAPEISSNSIKDSLVINERKDFSKNFEKNDIKERGPP--KKRRQEL 1391

  Fly  1149 DMERQSGNKLHPPPYVKIKTNK---AVP-----------------PLRFSQNLE--------DL- 1184
            :.:.:|..:|.....|:::..:   :||                 |.|:.:..:        ||
  Rat  1392 ESDSESDGELQARKKVRVEIEQGQSSVPQHSELVGPSCAMDDFRDPQRWKEFAKLGKMPCYFDLI 1456

  Fly  1185 --------------------STCNCLPVD-------EHPCGPEAGCLNRMLFNECNPEYCKAGSL 1222
                                ..|.|.|:.       |..||.:  ||||:|..||:.. |..|..
  Rat  1457 EENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEVACGED--CLNRLLMIECSSR-CPNGDY 1518

  Fly  1223 CENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDEN 1287
            |.||.|::::...:||:...::|:||...:.:....||:||.|||::|.||:.|:::..|:::.:
  Rat  1519 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIH 1583

  Fly  1288 YYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLW 1352
            |||:.::.|.||||..|||.:|||||||||||||||||||...|||.|..|.:|..|||||:|.:
  Rat  1584 YYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQF 1648

  Fly  1353 DDLMNNSKKACFCGAKRCSGEIGGKLKDDAVKAHAKLKQMRRAKASAV 1400
            ......::| ||||:..|.|.:||:.:.....|..|:|:.|..|..:|
  Rat  1649 QRYGKEAQK-CFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSV 1695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	19/122 (16%)
		PHD2_NSD	867..932	CDD:277040	17/72 (24%)
		PHD3_NSD	933..988	CDD:277041	8/55 (15%)
		PHD4_NSD	1001..1041	CDD:277042	4/39 (10%)
		WHSC1_related	1047..1141	CDD:99899	17/107 (16%)
		AWS	1183..1233	CDD:197795	21/77 (27%)
		SET	1234..1354	CDD:214614	59/119 (50%)
Setd2	XP_038937536.1	AWS	1475..1529	CDD:197795	19/56 (34%)
		SET_SETD2	1529..1670	CDD:380949	66/141 (47%)
		WW	2370..2399	CDD:395320
		SRI	2446..2534	CDD:400510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920