DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD and Ash1l

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_008759376.1 Gene:Ash1l / 310638 RGDID:1306350 Length:2958 Species:Rattus norvegicus


Alignment Length:1573 Identity:325/1573 - (20%)
Similarity:547/1573 - (34%) Gaps:507/1573 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 EDLGIRPIVRK--HVKRKMKRVPKAK---------VTLELDEKNQQEVDEKSVKTEPIDEEVDRT 272
            :.|.:.|..:|  ..||:|:...|.|         |..|...|.:.|.:.....::..:.|....
  Rat   877 QSLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESENHRSSSDFFESEDQLQ 941

  Fly   273 DEAPTQEAQTTAISIKSETEAEHKAAVDVH------------IKQEDTIRLDIVNNPVESTSIVI 325
            |....:::...::...|:.|.|....:...            |.:..|::...:.|.:.|:|:..
  Rat   942 DTDDLEDSHRQSVCSVSDLEMEPDKKISKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVES 1006

  Fly   326 TEEPK---DLEKSTEELA--FALPLASSTEVDLK-----------SPPDLSSTALATSIKSPSSV 374
            :.:.|   .|..:...||  |...|.....|..|           .|..:.:..|:   .||:|:
  Rat  1007 SNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGLLS---GSPASL 1068

  Fly   375 SI-----DSAKG--LSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRS 432
            ::     ..|.|  |..:..|..|:         ...|....|..:|....|...|..|......
  Rat  1069 AVLEQTAQQAAGSALGQILPPLLPS---------PASSSEILPSPICSQSSGTSGGQSPVSSDAG 1124

  Fly   433 SLDNANVP-IQVHVR----------FFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKS 486
            .::.::|| :.||.|          ..|..|||. :.|..||..:.             .|..:.
  Rat  1125 FVEPSSVPYLHVHSRQGSMIQTLAMKKAAKGRRR-LSPPTLLPNSP-------------SHLSEL 1175

  Fly   487 AKYRQMVPKRTKVVIWRQAIEEAQAMTQIP-----------YSDRLEKFYQTYENVVTLNRQKRK 540
            ...::..|         ..:.|:.:...||           .|||.|||.          .||::
  Rat  1176 TSLKEATP---------SPVSESHSDETIPSDSGIGTDNNSTSDRAEKFC----------GQKKR 1221

  Fly   541 RTKY-----MMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKR 600
            |..:     :..:||.|.:||.:...:...::....|:..               |.|.:||.::
  Rat  1222 RHSFEHISLIPPETSTVLNSLKEKHKHKCKRRSHDYLSYD---------------KMKRQKRKRK 1271

  Fly   601 RK---LSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLL 662
            :|   |.|..:.|..:                      |..:|:|.:.|..:.:||...:.:.||
  Rat  1272 KKYPQLRNRQDPDFIA----------------------ELEELISRLSEIRITHRSHHFIPRDLL 1314

  Fly   663 SVVSNI---------------------WSLKQIQLRELERDLASGE------IEEPLGSS----- 695
            ..:..|                     ..||:.:.|..:...|..|      :..||.|:     
  Rat  1315 PTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPS 1379

  Fly   696 ---------VVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPS-TTPAP----SEPDRRLSEPPK 746
                     :.....|:|...|....|        ..|..:|| |||.|    ......|..|.|
  Rat  1380 YGMPYSPSPLTAAPIGLGYYGRYPPTL--------YPPPPSPSFTTPLPPPSYMHAGHLLLNPTK 1436

  Fly   747 TKKPVNRPIEEVIEDIL------------------------QLDSKYLFR--------------- 772
            ..|..::.:.:  |..|                        .::.|:..|               
  Rat  1437 YHKKKHKLLRQ--EAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSEQPQVSM 1499

  Fly   773 --GLSR---EPICKYCYQAGSDLV----------RCSRTC-------------SSWLHADCLERK 809
              |.||   |.:.:|.:  |.|.|          ||..:|             ..|     :.|:
  Rat  1500 DTGSSRSVLESLKRYRF--GKDTVGDRYKHKEKHRCHMSCPHLSPSKSLINREEQW-----VSRE 1557

  Fly   810 VTGAPMPKIGSRKALVIPPTSKSPS-------PDEDHVTADAKEVVAVGTSLVCHECNVGEPEGC 867
            .:.:....:|.:..|.|..:..|||       |:.:..::|  |.:.:.||.: ..|.|..|...
  Rat  1558 PSESSSLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSD--EHMNLFTSAI-GSCRVSNPNSS 1619

  Fly   868 VICHQVESPAV-P------STPRKEDSSSHTPIEDKLLTCSQPMCGKRFH-----TSCCKYWPQA 920
            ......:||.: |      |.|.:::....|....:.|..||....|...     |:|.....::
  Rat  1620 CRKKLTDSPGLFPVQDTALSRPHRKEPLPSTERAIQSLAGSQSASDKPSQRSSESTNCSPTRKRS 1684

  Fly   921 SSSKHS-------ARCPRHVCH-----------------------------TCVSDDPS------ 943
            ||...|       :|.||.|..                             |.||..||      
  Rat  1685 SSESTSSTVNGIPSRSPRLVASLDDSVDCLLQRIVQHDEQESVEKNGDAPITTVSAPPSSSPGHS 1749

  Fly   944 -GKFQQLGSSKLA--------KCVRCPATYHQL-SKCIP-------------AGTQMLNTTNIIC 985
             .|.:.||.|...        .|...|....:| |:|.|             ...:|.|...|:.
  Rat  1750 YSKERTLGKSDSLLVPAVPSDSCNSIPLLSEKLASRCSPHHIKRSVVEAMQRQARKMCNYDKILA 1814

  Fly   986 PRHNIAKADAHVN-----------------------------VLWCYICVKG------------- 1008
            .:.|:    .|||                             .|...:.::.             
  Rat  1815 TKKNL----DHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPELNE 1875

  Fly  1009 GELVCCETCPIAV----HAHCRNIPIKT-------NESYICEE---CESGRLPLYGEIVWAKFNN 1059
            ||.|.....|..|    .|..:::.:.:       .::::.||   .:...:|...|    :.||
  Rat  1876 GEEVSLHLSPDTVTDVIEAVVQSVNLNSEHKKGWKRKNWLLEEQTRKKQKTVPEEEE----QENN 1936

  Fly  1060 FRWWPAIILPPTEVPSNI---LKKAHGENDF--VVRFFGTHDHGWISRRRVY----LYIEGDTGD 1115
                .:.|..|.|:||.:   .:.:..|::.  |:.............::.|    ||     .|
  Rat  1937 ----KSFIEKPVEIPSPLETPAEPSEPESNLQPVLALIPREKKAPRPPKKKYQRAGLY-----SD 1992

  Fly  1116 GHKT---KSQLFR------NYTTGVEEASRF---LPIIKARRQEQ-DME-------RQSGNKLHP 1160
            .:||   ||:|.:      .||.|..|...|   :.:.|..||:: |.:       :...|:|:.
  Rat  1993 VYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYK 2057

  Fly  1161 PP----YVKIKTN--KAVPPLRFSQNLEDLSTCNCLPVDEHP---CGPEAGCLNRMLFNECNPEY 1216
            .|    |.||::|  ..|.||    :..:.:||||...|:..   ||.:  |||||:|.||:|..
  Rat  2058 KPDVPLYKKIRSNVYVDVKPL----SGYEATTCNCKKPDDDTRKGCGDD--CLNRMIFAECSPNT 2116

  Fly  1217 CKAGSLCENRMFEQRKSPR-LEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQK 1280
            |..|..|.|:..::.:..: ||.....|:|:|:..:||:..|.|:|||:|||::..||:.||.::
  Rat  2117 CPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQ 2181

  Fly  1281 QRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSE 1345
            ..:..: :|.|.::...:||:...||.|||:||||:||||.|||:||.::|:|::|:||:|..:|
  Rat  2182 YHNHSD-HYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDVPAGTE 2245

  Fly  1346 LTFNYLWDDLMNNSKKACFCGAKRCSGEIGGK-LKDDAVKAH------------AKLKQMRRAKA 1397
            ||::|.:.......::.|.||.::|.|.|||| .:.:.:.:|            |:.|:.|::|.
  Rat  2246 LTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRMNGLPSHKGSQPASTHRKSARSKEKRKSKH 2310

  Fly  1398 SAVRIHVKPKKTP 1410
            ...:....|.:.|
  Rat  2311 KLKKRRGHPSEEP 2323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 21/127 (17%)
PHD2_NSD 867..932 CDD:277040 17/83 (20%)
PHD3_NSD 933..988 CDD:277041 19/112 (17%)
PHD4_NSD 1001..1041 CDD:277042 8/66 (12%)
WHSC1_related 1047..1141 CDD:99899 25/114 (22%)
AWS 1183..1233 CDD:197795 20/52 (38%)
SET 1234..1354 CDD:214614 51/120 (43%)
Ash1lXP_008759376.1 AWS 2082..2133 CDD:197795 20/52 (38%)
SET_ASH1L 2136..2276 CDD:380951 57/140 (41%)
Bromo_ASH1 2432..2537 CDD:99955
PHD_ASH1L 2575..2617 CDD:277023
BAH_polybromo 2654..2788 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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