DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and Nsd1

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_006253682.1	Gene:	Nsd1 / 306764	RGDID:	1307748	Length:	2689	Species:	Rattus norvegicus

Alignment Length:	1578	Identity:	413/1578 - (26%)
Similarity:	640/1578 - (40%)	Gaps:	421/1578 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNP----VQNGAQPAAEESELE 87
            :|.||.:..|...|.|:.....|       .|.:|:..:.|.|:..    :.|..:...:.|::|
  Rat   795 ESPTAAETSATSEDLSLKCCSSD-------TNGSPMTSISKSGKGEGLKLLNNMHEKTRDSSDIE 852

  Fly    88 SQRQTPVQK---QQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPT---------------PL 134
                |.|.|   .:.:.:|..:...|:.:..::.|.|.:.:::|:|..               .|
  Rat   853 ----TAVVKHVLSELKELSYRSLSEDVSDSGTSKSSKPLLFSSASSQNHIPIEPDYKFSTLLMML 913

  Fly   135 SDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPI-- 197
            .|..|: :|..:|:             ..|.:.||.|||..|....|             ||:
  Rat   914 KDMHDS-KTKEQRL-------------MTAQNVASYRTPDRGDCSSG-------------SPVGT 951

  Fly   198 EKLLI---------KNGASSPNSTGFEAG----------SEDLGIRP----------------IV 227
            .|:|:         |.|.|:.:|.....|          |..|.:.|                |.
  Rat   952 SKVLVLGGSTHNSEKPGDSTQDSVRLSPGGGDSALSGELSSSLSVLPSDKRDLPACGKIRSNCIP 1016

  Fly   228 RKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETE 292
            |::..| .|..||.:||:. .:..:..|:.|::|||       |..:.....|.|.|.:.....|
  Rat  1017 RRNCGR-AKLSPKLRVTIS-TQMAKPSVNPKALKTE-------RKRKLSRLPAVTLAANGLGNKE 1072

  Fly   293 A------EHKAAVDVHIKQEDTIRLDIVNNPVEST---SIVITEEP-KDLEKSTEELAFALPLAS 347
            :      ..|.......|:|...::|::.|  |.|   |.|...:| |.|||   |.:|.
  Rat  1073 SGGSVNGPLKGGAQDPAKEEPLQQMDLLRN--EETHFDSKVKQSDPDKILEK---EPSFE----- 1127

  Fly   348 STEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGL-SIVTDPGWPTYQVGDLFWGKVFSYCFWPC 411
                :.|.|          .:.|..::..|...|: .:|....|
  Rat  1128 ----NRKGP----------EVGSEINIENDEPHGVDQVVPKKRW--------------------- 1157

  Fly   412 MVCPDPLGQIVGNMPSHPQRSS----LDNA---------NVPIQVHVRFFADNGRRNWIK----P 459
                ..|.|   ..|...:|:|    .:|:         ..|:|        .||.::::    |
  Rat  1158 ----QRLNQ---RRPKPGKRASRFREKENSEGAFGVLLPGDPVQ--------KGRDDYLEQRAPP 1207

  Fly   460 ENLLTFAGLKAFDDMREELRIKH----GP------KSAKYRQMVPKRTKVVIWRQAIEEAQAMTQ 514
            .::|.       |...:...:.|    ||      ||:.....:.|.|       .|......|:
  Rat  1208 TSILE-------DSAADPNHVSHSESVGPRLNVCDKSSVSMGDLEKET-------GIPSLTPQTK 1258

  Fly   515 IPY-SDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRER 578
            ||. :.|.||            ::.||.:|::::.|.:     ||           |:.|.|:::
  Rat  1259 IPEPAVRSEK------------KRLRKPSKWLLEYTEE-----YD-----------QIFAPKKKQ 1295

  Fly   579 SESPFSPAFSPVKSKNEKR---AKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAY-ENP---- 635
            .:  .......|.|:.|..   |:.|..:...:.|  .||:..|..:.......:.: |.|
  Rat  1296 KK--VQEQVHKVSSRCEDESLLARCRSSAQNKQVD--ENSLISTKEEPPVLEREAPFLEGPLVQS 1356

  Fly   636 -------EFRQL-LSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQ-------IQLRELE----- 680
                   |..|| ||..:...:..|...:.|::|:....|....:|       ::..:|:
  Rat  1357 DLGVAHAELPQLTLSVPVAPEVSPRPTLESEELLVKTPGNYEGKRQRKPTKKLLESNDLDPGFMP 1421

  Fly   681 --RDLA-------SGEIEEPLGSS-----VVGRGSGVGTI-----KRLSNRLMTMMVR-RSMTPV 725
              .||.       ||.:|..:|.|     :...|.|...|     ||...|..|..|. :.:...
  Rat  1422 KKGDLGLSRKCCESGHLENGVGDSRATPHLKEFGGGTTRIFDKPRKRKRQRHGTARVHYKRVKKE 1486

  Fly   726 VTPSTTPAPSEPD---RRLSEPPKTKKPVNRPIEEVIEDILQLD-----SKYL--FRG---LSRE 777
            .:...||:.:|.:   .|.:..||          |::|:.::.|     ||.|  .||   ..:|
  Rat  1487 DSARETPSSAEGELMIHRTAASPK----------EILEEGIEHDPGMSASKRLQGERGGGAALKE 1541

  Fly   778 PICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTA 842
            .:|:.|.:.| :|:.|...|....|.:||                .|...|..|
  Rat  1542 NVCQNCEKLG-ELLLCEAQCCGAFHLECL----------------GLTEMPRGK----------- 1578

  Fly   843 DAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGK 907
                       .:|:||..| ...|.:|.|          ..||          :..|..|:|||
  Rat  1579 -----------FICNECRTG-IHTCFVCKQ----------SGED----------VKRCLLPLCGK 1611

  Fly   908 RFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIP 972
            .:|..|.:.:|.........|||.|:|.||.:.:|:......|  :|.:|||||..||....|:.
  Rat  1612 FYHEECVQKYPPTVVQNKGFRCPLHICITCHAANPANVSASKG--RLMRCVRCPVAYHANDFCLA 1674

  Fly   973 AGTQMLNTTNIICPRHNIAKADA----HVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTN 1033
            ||:::|.:.:||||.|...:...    ||||.||::|.:||.|:||::||.|.|..|.||.|...
  Rat  1675 AGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEG 1739

  Fly  1034 ESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHG 1098
            ..| |.:|::|:.|.|.||||.|...:|||||.|..|..|||||.|..|...:|.|.|||::|:.
  Rat  1740 NWY-CNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYL 1803

  Fly  1099 WISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPY 1163
            |..:.||:.|:|||.....|....:...|...::||:.....:||:::.:.::....|...||||
  Rat  1804 WTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPY 1868

  Fly  1164 VKIKTNKAVPPLR-FSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRM 1227
            ..||.|:.:..:: |:.:|.::..|||...||:|||.::.|:||||..||:|..|.||..|:|:.
  Rat  1869 KHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQC 1933

  Fly  1228 FEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLG 1292
            |.:|:.|.:|:....:||:||..:..|..|:||.|||||:|:..|.:.|:...|.....|:|.|.
  Rat  1934 FSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLT 1998

  Fly  1293 VEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMN 1357
            ::||.|||||||||.||||||.|:||||||||:||...|||:||:.||...:||||||.. :.:.
  Rat  1999 LDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNL-ECLG 2062

  Fly  1358 NSKKACFCGAKRCSGEIGGKLKDDAV-----------KAHAKLKQMRRAKASAVR---------- 1401
            |.|..|.|||..|||.:|.:.|:..:           |.|.|    ||::....:
  Rat  2063 NGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGK----RRSQGEVTKEREDECFSCG 2123

  Fly  1402 -----IHVKPKKTPKVKH 1414
                 :..|....|||.|
  Rat  2124 DGGQLVSCKKPGCPKVYH 2141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	21/143 (15%)
		PHD2_NSD	867..932	CDD:277040	16/64 (25%)
		PHD3_NSD	933..988	CDD:277041	21/54 (39%)
		PHD4_NSD	1001..1041	CDD:277042	18/39 (46%)
		WHSC1_related	1047..1141	CDD:99899	38/93 (41%)
		AWS	1183..1233	CDD:197795	23/49 (47%)
		SET	1234..1354	CDD:214614	63/119 (53%)
Nsd1	XP_006253682.1	MSH6_like	319..429	CDD:99898
		PHD1_NSD1_2	1543..1585	CDD:277118	14/80 (18%)
		PHD2_NSD1	1590..1636	CDD:277120	16/65 (25%)
		PHD3_NSD1	1637..1690	CDD:277123	21/54 (39%)
		PHD4_NSD1	1707..1746	CDD:277126	18/39 (46%)
		WHSC1_related	1752..1846	CDD:99899	38/93 (41%)
		AWS	1889..1939	CDD:197795	23/49 (47%)
		SET	1940..2063	CDD:214614	63/123 (51%)
		PHD5_NSD1	2118..2160	CDD:277129	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5113
eggNOG	1	0.900	-	-		E2759_KOG1081
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1355
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38976at33208
OrthoFinder	1	1.000	-	-		FOG0001511
OrthoInspector	1	1.000	-	-		otm44534
orthoMCL	1	0.900	-	-		OOG6_102558
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X847
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870