Protein Alignment NSD and Nsd3

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_038950324.1
• Gene: Nsd3 / 290831
• RGDID: 1308980
• Length: 1444
• Species: Rattus norvegicus
• Alignment Length: 1565
• Identity: 413/1565 - (26%)
• Similarity: 623/1565 - (39%)
• Gaps: 419/1565 - (26%)

  Fly    47 GDDVEIPRDTNNSTPVRLLDKPGQNP--VQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKR 109
            |:.::.|....:|..:|..|....|.  |::|. |...|:.|:...|.|  ...:....:.|...
  Rat    13 GNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGG-PTPFEATLQQGFQCP--PATEDLPPLTNGYP 74

  Fly   110 DLINLQSALS--PKYIGYANAN----------SPTPLSDSDDTIRTTRRRVNQAAALNNSSAGET 162
            ..|:|....:  |.|..|.|.:          |||....|:  |..||..    ..|...|..:.
  Rat    75 PSISLYETQTKYPPYSQYPNGSANGFGAVRNFSPTDYYHSE--IPNTRPH----EILEKPSPPQP 133

  Fly   163 LAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKL----LIKNGASSPNSTGFEAG------ 217
            .......|..|         .....::.|...||..||    .|:||...     ||:.
  Rat   134 PPPPLLPPPPP---------PVPQTVIPKKTGSPEIKLKITKTIQNGREL-----FESSLCGDLL 184

  Fly   218 SEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEP-----IDEEVDRTDEAPT 277
            :|......:..||..||.||   .|.:.....::::....|..|.||     .:|.||...|.|.
  Rat   185 NEVQASEHLKSKHESRKEKR---KKSSRHESSRSEERKSHKVPKLEPEGQNRPNERVDPAPEKPR 246

  Fly   278 QEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFA 342
            :|...             |.||                 ||:
  Rat   247 EEPVL-------------KEAV-----------------PVQ----------------------- 258

  Fly   343 LPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYC 407
             |:.||          :.:|..:|.:|                       :|||||.|.||.:|.
  Rat   259 -PILSS----------VPTTETSTGVK-----------------------FQVGDLVWSKVGTYP 289

  Fly   408 FWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFD 472
            :|||||..||..::...:.:...|          :.||:||::...|.|:..:.:..:.|.:.::
  Rat   290 WWPCMVSSDPQLEVHTKINTRGAR----------EYHVQFFSNQPERAWVHEKRVREYKGHEQYE 344

  Fly   473 DMREEL---RIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTL 534
            ::..|.   ...|..|. |.|:..|:|.:.. |...|..|:...|:...:|:|::...|
  Rat   345 ELLAEAAKQASNHSEKQ-KIRKPRPQRERAQ-WDIGIAHAEKALQMTREERVEQYTFIY------ 401

  Fly   535 NRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNE-KRA 598
                                                   :.::..||| |.|...|.||.| |:.
  Rat   402 ---------------------------------------IDKQPEESP-SQAKKSVTSKAEVKKP 426

  Fly   599 KR-RKLSNGTEADTGSNSMAVTPSQTE---------TTVDSS-------AYENPEFRQLLSAVME 646
            :| |.:.|.....|.:..:|...|.|:         |:|:..       |:.....|:.|.|
  Rat   427 RRPRSVGNSQPEQTSAGEVASPQSSTDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPA--- 488

  Fly   647 YVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSN 711
            .:.|::....:.|..:|.|     :|..|:..|:.....|:..:....|..|.|:......|..:
  Rat   489 SITMHKGSLDLHKCNMSPV-----VKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQD 548

  Fly   712 RLMTMMVRRSMTPVVTPS-----TTPAPSEPD------------------RRLSEPPK-----TK 748
            ||:          :.:||     :||:.|.|:                  |..||..|     :|
  Rat   549 RLI----------ISSPSQRNEKSTPSASPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSK 603

  Fly   749 KPVNRPIEEVIEDILQLDSKY-LFRGLSR-----EPICKYCYQAGSDLVRCSRTCSSWLHADCLE 807
            |.:.:  |:.:|...|...|. |.:|.|.     :|:.|.. :|.:|:...|.|     :.|..:
  Rat   604 KKIKK--EQQVETSPQASLKTGLQKGASEISDSCKPLKKRS-RASTDVETASCT-----YRDTSD 660

  Fly   808 RKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSL------------VCHEC- 859
            ....|....::|..|.:      .|||...|   |||.:..:|.:||            ||..|
  Rat   661 SDSRGPSDGQVGFGKQV------DSPSAAAD---ADASDAQSVDSSLSRRGVGLSKKDTVCQVCE 716

  Fly   860 NVGE-----------------------PEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCS 901
            |.|:                       |||...|.:.|:...|....|.....       :..||
  Rat   717 NTGDSLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGKD-------VKRCS 774

  Fly   902 QPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQ 966
            ..:|||.:|.:|.:.:|.|.......|||:|.|.:|..:.   ...:....::.||:|||..||.
  Rat   775 VSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEK---DIHKASKGRMMKCLRCPIAYHF 836

  Fly   967 LSKCIPAGTQMLNTTNIICPRHNIAKADAH---VNVLWCYICV---------------------- 1006
            ...|:.||:..:::..:||..|  :|..:|   :||.:|::|.
  Rat   837 GDACVAAGSVSVSSHILICSNH--SKRSSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHY 899

  Fly  1007 ---------------------------KGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESG 1044
                                       |||.|:|||:||.:.|..|.:|.:... .:.|.:|::|
  Rat   900 LLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEG-CWNCNDCKAG 963

  Fly  1045 RLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYI 1109
            :...|.:|||.|..|:|||||....|..||.||....||..||.|.|||:||:.|:.:.||:.|:
  Rat   964 KKLHYKQIVWVKLGNYRWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPYV 1028

  Fly  1110 EGDT--GDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAV 1172
            ||||  .:|..:.::.|:.   .:|||::....:||:|:.::..........||||..||.||.:
  Rat  1029 EGDTNFAEGQTSINKTFKK---ALEEAAKRFQELKAQRESKEALEIEKTSRKPPPYKHIKANKVI 1090

  Fly  1173 PPLRFS-QNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRL 1236
            ..::.. .:|.::..|||.|.||:|||.|:.|||||...||:|:.|.||..|:|:.|.:|..|..
  Rat  1091 GKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDA 1155

  Fly  1237 EVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDA 1301
            |::....||:||..:..|..|:||.|||||:|:..|.:.|:::...:...|:|.|.|.||.||||
  Rat  1156 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDA 1220

  Fly  1302 GPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCG 1366
            |||||.:|||||||.|||||||||||...|||:||:.|||...||||||.. |.:.|.:..|.||
  Rat  1221 GPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNL-DCLGNGRTVCHCG 1284

  Fly  1367 AKRCSGEIGGKLKDDAVKA------HAKLKQMRRAKASAVRIH---------------VKPKKTP 1410
            |..|||.:|.:.|.....|      :||||:.||.||.|.:||               ...|..|
  Rat  1285 ADNCSGFLGVRPKSACTSAADEKTKNAKLKKRRRGKAEAKQIHEDYCFQCGDGGELVMCDKKDCP 1349

  Fly  1411 KVKHI 1415
            |..|:
  Rat  1350 KAYHL 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	33/121 (27%)
		PHD2_NSD	867..932	CDD:277040	16/64 (25%)
		PHD3_NSD	933..988	CDD:277041	14/54 (26%)
		PHD4_NSD	1001..1041	CDD:277042	15/88 (17%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	39/96 (41%)
		AWS	1183..1233	CDD:197795	25/49 (51%)
		SET_NSD	1233..1375	CDD:380950	74/141 (52%)
Nsd3	XP_038950324.1	PWWP_NSD3_rpt1	275..404	CDD:438991	38/185 (21%)
		PHD1_NSD3	711..753	CDD:277119	9/41 (22%)
		PHD2_NSD3	759..805	CDD:277122	14/52 (27%)
		PHD_SF	806..858	CDD:473978	14/54 (26%)
		PHD4_NSD3	925..960	CDD:277128	13/35 (37%)
		PWWP_NSD3_rpt2	967..1061	CDD:438994	39/96 (41%)
		AWS	1112..1150	CDD:465559	20/37 (54%)
		SET_NSD3	1152..1293	CDD:380989	74/141 (52%)
		PHD5_NSD3	1330..1372	CDD:277131	4/25 (16%)
		C5HCH	1371..1420	CDD:465605