DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD and Nsd3

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_038950324.1 Gene:Nsd3 / 290831 RGDID:1308980 Length:1444 Species:Rattus norvegicus


Alignment Length:1565 Identity:413/1565 - (26%)
Similarity:623/1565 - (39%) Gaps:419/1565 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 GDDVEIPRDTNNSTPVRLLDKPGQNP--VQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKR 109
            |:.::.|....:|..:|..|....|.  |::|. |...|:.|:...|.|  ...:....:.|...
  Rat    13 GNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGG-PTPFEATLQQGFQCP--PATEDLPPLTNGYP 74

  Fly   110 DLINLQSALS--PKYIGYANAN----------SPTPLSDSDDTIRTTRRRVNQAAALNNSSAGET 162
            ..|:|....:  |.|..|.|.:          |||....|:  |..||..    ..|...|..:.
  Rat    75 PSISLYETQTKYPPYSQYPNGSANGFGAVRNFSPTDYYHSE--IPNTRPH----EILEKPSPPQP 133

  Fly   163 LAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKL----LIKNGASSPNSTGFEAG------ 217
            .......|..|         .....::.|...||..||    .|:||...     ||:.      
  Rat   134 PPPPLLPPPPP---------PVPQTVIPKKTGSPEIKLKITKTIQNGREL-----FESSLCGDLL 184

  Fly   218 SEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEP-----IDEEVDRTDEAPT 277
            :|......:..||..||.||   .|.:.....::::....|..|.||     .:|.||...|.|.
  Rat   185 NEVQASEHLKSKHESRKEKR---KKSSRHESSRSEERKSHKVPKLEPEGQNRPNERVDPAPEKPR 246

  Fly   278 QEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFA 342
            :|...             |.||                 ||:                       
  Rat   247 EEPVL-------------KEAV-----------------PVQ----------------------- 258

  Fly   343 LPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYC 407
             |:.||          :.:|..:|.:|                       :|||||.|.||.:|.
  Rat   259 -PILSS----------VPTTETSTGVK-----------------------FQVGDLVWSKVGTYP 289

  Fly   408 FWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFD 472
            :|||||..||..::...:.:...|          :.||:||::...|.|:..:.:..:.|.:.::
  Rat   290 WWPCMVSSDPQLEVHTKINTRGAR----------EYHVQFFSNQPERAWVHEKRVREYKGHEQYE 344

  Fly   473 DMREEL---RIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTL 534
            ::..|.   ...|..|. |.|:..|:|.:.. |...|..|:...|:...:|:|::...|      
  Rat   345 ELLAEAAKQASNHSEKQ-KIRKPRPQRERAQ-WDIGIAHAEKALQMTREERVEQYTFIY------ 401

  Fly   535 NRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNE-KRA 598
                                                   :.::..||| |.|...|.||.| |:.
  Rat   402 ---------------------------------------IDKQPEESP-SQAKKSVTSKAEVKKP 426

  Fly   599 KR-RKLSNGTEADTGSNSMAVTPSQTE---------TTVDSS-------AYENPEFRQLLSAVME 646
            :| |.:.|.....|.:..:|...|.|:         |:|:..       |:.....|:.|.|   
  Rat   427 RRPRSVGNSQPEQTSAGEVASPQSSTDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPA--- 488

  Fly   647 YVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSN 711
            .:.|::....:.|..:|.|     :|..|:..|:.....|:..:....|..|.|:......|..:
  Rat   489 SITMHKGSLDLHKCNMSPV-----VKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQD 548

  Fly   712 RLMTMMVRRSMTPVVTPS-----TTPAPSEPD------------------RRLSEPPK-----TK 748
            ||:          :.:||     :||:.|.|:                  |..||..|     :|
  Rat   549 RLI----------ISSPSQRNEKSTPSASPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSK 603

  Fly   749 KPVNRPIEEVIEDILQLDSKY-LFRGLSR-----EPICKYCYQAGSDLVRCSRTCSSWLHADCLE 807
            |.:.:  |:.:|...|...|. |.:|.|.     :|:.|.. :|.:|:...|.|     :.|..:
  Rat   604 KKIKK--EQQVETSPQASLKTGLQKGASEISDSCKPLKKRS-RASTDVETASCT-----YRDTSD 660

  Fly   808 RKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSL------------VCHEC- 859
            ....|....::|..|.:      .|||...|   |||.:..:|.:||            ||..| 
  Rat   661 SDSRGPSDGQVGFGKQV------DSPSAAAD---ADASDAQSVDSSLSRRGVGLSKKDTVCQVCE 716

  Fly   860 NVGE-----------------------PEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCS 901
            |.|:                       |||...|.:.|:...|....|.....       :..||
  Rat   717 NTGDSLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGKD-------VKRCS 774

  Fly   902 QPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQ 966
            ..:|||.:|.:|.:.:|.|.......|||:|.|.:|..:.   ...:....::.||:|||..||.
  Rat   775 VSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEK---DIHKASKGRMMKCLRCPIAYHF 836

  Fly   967 LSKCIPAGTQMLNTTNIICPRHNIAKADAH---VNVLWCYICV---------------------- 1006
            ...|:.||:..:::..:||..|  :|..:|   :||.:|::|.                      
  Rat   837 GDACVAAGSVSVSSHILICSNH--SKRSSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHY 899

  Fly  1007 ---------------------------KGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESG 1044
                                       |||.|:|||:||.:.|..|.:|.:... .:.|.:|::|
  Rat   900 LLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEG-CWNCNDCKAG 963

  Fly  1045 RLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYI 1109
            :...|.:|||.|..|:|||||....|..||.||....||..||.|.|||:||:.|:.:.||:.|:
  Rat   964 KKLHYKQIVWVKLGNYRWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPYV 1028

  Fly  1110 EGDT--GDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAV 1172
            ||||  .:|..:.::.|:.   .:|||::....:||:|:.::..........||||..||.||.:
  Rat  1029 EGDTNFAEGQTSINKTFKK---ALEEAAKRFQELKAQRESKEALEIEKTSRKPPPYKHIKANKVI 1090

  Fly  1173 PPLRFS-QNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRL 1236
            ..::.. .:|.::..|||.|.||:|||.|:.|||||...||:|:.|.||..|:|:.|.:|..|..
  Rat  1091 GKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDA 1155

  Fly  1237 EVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDA 1301
            |::....||:||..:..|..|:||.|||||:|:..|.:.|:::...:...|:|.|.|.||.||||
  Rat  1156 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDA 1220

  Fly  1302 GPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCG 1366
            |||||.:|||||||.|||||||||||...|||:||:.|||...||||||.. |.:.|.:..|.||
  Rat  1221 GPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNL-DCLGNGRTVCHCG 1284

  Fly  1367 AKRCSGEIGGKLKDDAVKA------HAKLKQMRRAKASAVRIH---------------VKPKKTP 1410
            |..|||.:|.:.|.....|      :||||:.||.||.|.:||               ...|..|
  Rat  1285 ADNCSGFLGVRPKSACTSAADEKTKNAKLKKRRRGKAEAKQIHEDYCFQCGDGGELVMCDKKDCP 1349

  Fly  1411 KVKHI 1415
            |..|:
  Rat  1350 KAYHL 1354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 33/119 (28%)
PHD2_NSD 867..932 CDD:277040 16/64 (25%)
PHD3_NSD 933..988 CDD:277041 14/54 (26%)
PHD4_NSD 1001..1041 CDD:277042 15/88 (17%)
WHSC1_related 1047..1141 CDD:99899 39/95 (41%)
AWS 1183..1233 CDD:197795 25/49 (51%)
SET 1234..1354 CDD:214614 65/119 (55%)
Nsd3XP_038950324.1 MSH6_like 274..390 CDD:99898 36/150 (24%)
PHD1_NSD3 711..753 CDD:277119 9/41 (22%)
PHD2_NSD3 759..805 CDD:277122 14/52 (27%)
PHD_SF 806..858 CDD:419867 14/54 (26%)
PHD4_NSD3 925..960 CDD:277128 13/35 (37%)
WHSC1_related 966..1059 CDD:99899 39/95 (41%)
AWS 1112..1150 CDD:407759 20/37 (54%)
SET_NSD3 1152..1293 CDD:380989 74/141 (52%)
PHD5_NSD3 1330..1372 CDD:277131 4/25 (16%)
C5HCH 1371..1420 CDD:407828
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 131 1.000 Domainoid score I5026
eggNOG 1 0.900 - - E2759_KOG1081
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D38976at33208
OrthoFinder 1 1.000 - - FOG0001511
OrthoInspector 1 1.000 - - otm44534
orthoMCL 1 0.900 - - OOG6_102558
Panther 1 1.100 - - LDO PTHR22884
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X847
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.820

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