DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and SETD2

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_011531934.1 Gene:SETD2 / 29072 HGNCID:18420 Length:2572 Species:Homo sapiens


Alignment Length:1769 Identity:358/1769 - (20%)
Similarity:568/1769 - (32%) Gaps:651/1769 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 KNGASSPN--STGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEV---------- 255
            :|.|...|  .|||..|....|:..      .|.:.:..|.||.||  |:.:|:|          
Human    35 ENEAKIENVQKTGFIKGPMFKGVAS------SRFLPKGTKTKVNLE--EQGRQKVSFSFSLTKKT 91

  Fly   256 ----------DEKSVKT---EPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQED 307
                      :||...|   ..:..:||.|.:...:...|.:.:.:|...........:|.|:. 
Human    92 LQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKH- 155

  Fly   308 TIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALP--LASSTEVDL--KSPPDLSSTALATSI 368
              .|.:.:.|:.:|:..:...|..        |..||  :|.||.||.  .|||.....|.||::
Human   156 --LLHVTSRPLLATTTAVASPPTH--------AAPLPAVIAESTTVDSPPSSPPPPPPPAQATTL 210

  Fly   369 KSPSSVSIDSAKGLSIVTDP-GWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVG--------- 423
            .||:.           ||:| ..|...:..|             |..|.||...|.         
Human   211 SSPAP-----------VTEPVALPHTPITVL-------------MAAPVPLPVDVAVRSLKEPPI 251

  Fly   424 -----NMPSHPQRSSLDNANVPIQVHVRFFADN-------------GRRNWIKPENLLTFA---- 466
                 ::.:..::.::.|:   ::.||....:.             |:...|...:.::.:    
Human   252 IIVPESLEADTKQDTISNS---LEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKT 313

  Fly   467 GLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQ--AMTQIPY------------ 517
            |.|......|.:.:.........|....:|:..:.:..:||:.:  ..:..|.            
Human   314 GSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSK 378

  Fly   518 SDRLEKF--YQTYEN----VVTLNRQKRKRTKYMMQDTSDVG------------SSLYDSTDNLH 564
            :||.:|:  |...|.    |.:..|.:|:|.:......|:.|            |..|||....|
Human   379 TDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYH 443

  Fly   565 NKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAK----RRKLSNGT---EADTGSNSMAVTPSQ 622
            .....:    :|.|...|::...:...|.:|:..|    ||..|:.:   :..|.|.|.:....:
Human   444 RSSPYR----ERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCK 504

  Fly   623 TETTV-----------------------------------------------DSSA--YE----- 633
            |||:.                                               ||||  |:     
Human   505 TETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSK 569

  Fly   634 -----------------NPEFRQLLSAVM--------EYVMMNRSDEKVEKVLLSVVSN------ 667
                             |.|.:|..|..:        |..|:|::.|: ||......||      
Human   570 PIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPER-EKAGSPAPSNRLNDSP 633

  Fly   668 -----------------------------IWSLKQIQLREL-------------ERDLA------ 684
                                         :..:|..|||..             |.|||      
Human   634 TLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSK 698

  Fly   685 ------------SGEIEEPLGSSVVGRGSGVGTIKRLSNRLM--TMMVR-------RSMTPVVTP 728
                        :|....||..:.:...:|...|.|...:.:  |.|:.       |...|:|:|
Human   699 TDAVLMTSDDSVTGSELSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSP 763

  Fly   729 STTPAPSEPDRRLSEPPKT--------KKPV--------------------------NRPIEEVI 759
                   ..|:.:|.|..|        |:||                          |...|.:.
Human   764 -------HQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIE 821

  Fly   760 EDILQLDS-KYLFRGLSREP-IC--------------KYCYQAGS-------------------- 788
            ..::::.| .::...|..:| ||              :|....||                    
Human   822 PSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSG 886

  Fly   789 -----------------DLVRCSRTCSSWLHADCLERKVT--------------GAPMPKIG--- 819
                             .|::|....|..|.|....:|.:              |:.:|..|   
Human   887 IASSLQSLPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGF 951

  Fly   820 -----------SRKAL---------VIPPTSKSP--SPDE----DHV-TADAKEVVAVGTSLVCH 857
                       |.|.|         ::|.....|  |.||    .|| |:|..|||.....|   
Human   952 ASRENRRNNGLSGKCLQEAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDL--- 1013

  Fly   858 ECNVGEPEGCVICHQVES----PAVPSTPRK-----------EDSSSHTPIEDKLL--------- 898
            ...:.:.:|.....:.:|    |.:.||..:           |..|..|..:|..:         
Human  1014 NLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVV 1078

  Fly   899 ----TCSQPM-----CGKRFHTSCCKY---W--PQASSSKH----------SARCP---RHVCHT 936
                ..:.||     |..|...|...|   |  .:..|.:|          |..||   :...|.
Human  1079 VVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHK 1143

  Fly   937 CVSDDPSGKFQQLGSSKLAKCVRCP-----------ATYHQLSKCIPAG-TQMLNTTNIICPRHN 989
            ....:|...|.|  ||:.....|.|           :|.|...|..|.| .....|.....|...
Human  1144 GTEKNPEISFTQ--SSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQ 1206

  Fly   990 -----IAKADAH--VNVLWCYICVKG--------GELVCCETCPI----AVHA--HCRNI----- 1028
                 |..:|..  .|..|.....:.        .||....:|.|    .:|:  ..||:     
Human  1207 QEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFS 1271

  Fly  1029 PIKTNESYICEECESGRLPLYGEIVWAKF---------------NNFRWWPAIILPP-------- 1070
            ..|.:.:|  ::.:|.    ||.....|:               .|..|.|....||        
Human  1272 QEKPSTTY--QQPDSS----YGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDR 1330

  Fly  1071 --TEVPSNILKKAHGENDFVVRFFGTHDHGWISRR--RVYLYIEGDTG--DGHKTKSQLFRNYTT 1129
              .:||.::......|.:     :...|....|.:  :..|.::.|.|  ...:..|...:: |.
Human  1331 TQGQVPDSLTDDREEEEN-----WDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKD-TL 1389

  Fly  1130 GVEEASRFL------------PIIKARRQEQDMERQSGNKLHPPPYVKIKTNK---AVPP----- 1174
            .|.|...|.            | :|.||||.:.:.:|..:|.....|:::..:   :|||     
Human  1390 AVNEKKDFSKNLEKNDIKDRGP-LKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSALV 1453

  Fly  1175 --------LRFSQNLEDLS---------------------------------TCNCLPVD----- 1193
                    .|..|..::.:                                 .|.|.|:.     
Human  1454 GPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERA 1518

  Fly  1194 --EHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAV 1256
              |..||.:  ||||:|..||:.. |..|..|.||.|::::...:||:...::|:||...:.:..
Human  1519 QGEIACGED--CLNRLLMIECSSR-CPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPS 1580

  Fly  1257 GDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCET 1321
            ..||:||.|||::|.||:.|:::..|:::.:|||:.::.|.||||..|||.:|||||||||||||
Human  1581 NTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCET 1645

  Fly  1322 QKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLKDDAVKAH 1386
            ||||||...|||.|..|.:|..|||||:|.:......::| ||||:..|.|.:||:.:.....|.
Human  1646 QKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQK-CFCGSANCRGYLGGENRVSIRAAG 1709

  Fly  1387 AKLKQMRRAKASAV 1400
            .|:|:.|..|..:|
Human  1710 GKMKKERSRKKDSV 1723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 18/147 (12%)
PHD2_NSD 867..932 CDD:277040 20/115 (17%)
PHD3_NSD 933..988 CDD:277041 15/66 (23%)
PHD4_NSD 1001..1041 CDD:277042 10/58 (17%)
WHSC1_related 1047..1141 CDD:99899 22/134 (16%)
AWS 1183..1233 CDD:197795 19/89 (21%)
SET 1234..1354 CDD:214614 59/119 (50%)
SETD2XP_011531934.1 AWS 1503..1557 CDD:197795 19/56 (34%)
SET 1558..1681 CDD:214614 59/122 (48%)
PostSET 1682..1698 CDD:214703 7/16 (44%)
Asp-B-Hydro_N <1948..2131 CDD:191249
WW 2399..2428 CDD:278809
SRI 2477..2556 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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