DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and lin-59

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_491206.1	Gene:	lin-59 / 266825	WormBaseID:	WBGene00003040	Length:	1312	Species:	Caenorhabditis elegans

Alignment Length:	788	Identity:	153/788 - (19%)
Similarity:	256/788 - (32%)	Gaps:	287/788 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 GTIKRLSNRLMTMMVRRSMTP----VVTPSTTPAPS-----------EPDRRLSEPPK--TKKPV 751
            ||:...||...|   ..|.||    ...|::.|:||           ..|....:.|.  |..|:
Worm   157 GTVPMSSNAPAT---TSSATPDSGIQSVPTSPPSPSYAMMNDVDIGDHDDEEDDDGPADFTDMPL 218

  Fly   752 NRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMP 816
            .:|::|  :|                                          ||.:...|....|
Worm   219 LKPVDE--DD------------------------------------------DCYDVPCTSEGPP 239

  Fly   817 KIGSRKAL-VIPPTSKSPSPDEDHV----------------TADAKEVVAVGTSLVCHECNVGEP 864
            ...|..|: .||.:..:|:|.::.:                ..|.:|:|   ..|:.|:..:.:
Worm   240 PNNSNPAITTIPSSCSTPAPPKESLPTGMNVEEWGSFLIASNMDREEIV---RRLMAHDPEMAK- 300

  Fly   865 EGCVICHQVESPAVPSTPRKEDS----SSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKH 925
               .|..::...:...:.:|:|.    ||.||..                       |:|..::
Worm   301 ---AIAMRIRELSAEESKKKKDMEAEVSSTTPTT-----------------------PRARGTR- 338

  Fly   926 SARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNI 990
                .|:.|.|..::.|......|...        |:|               :|..::....::
Worm   339 ----TRNKCATRSTNSPDVTTSNLPEE--------PST---------------STMGLVKENEDV 376

  Fly   991 AKADA-------------HVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECE 1042
            .|.:.             |....                  ..:.:..:....:.:|.::.|...
Worm   377 EKVEGKRRGRKPKKRRGFHKESF------------------EDLESDAKKSKAEQHEDHLPEASC 423

  Fly  1043 SGRLPLYGEIVWAKFNNFRWWPAIILPP------------------------------TEVPSNI 1077
            |.|                  |..::||                              ||:..:.
Worm   424 SSR------------------PESVIPPPVDPIQFRLKVREMMERKLEQLTQKMSEDMTELRLSH 470

  Fly  1078 L---KKAHGE----NDFVVRFFGTHDH-----GWISRRRVYLYI-EGDTGDGHKTKSQLFRNYTT 1129
            |   |..:||    .:..:|.......     |.:.|:|:.::: |.|..:.:|.      |...
Worm   471 LTSSKMVNGERGKRRESFLRQLNEQSKKLRKGGMLGRKRLRMFMTESDILEENKD------NIKK 529

  Fly  1130 GVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVK------IKTNKAVP------PLRFSQNLE 1182
            .|:|.|...|.....|......|:....::|.|..|      .:..|:||      ||..:.:|
Worm   530 EVKEESTPPPTKLRGRLPSRRTREPSEIVNPEPVEKKFNGEYFEITKSVPSSDDIIPLWMAPSL- 593

  Fly  1183 DLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQR---------KSPRLEV 1238
               ||.|   .:..|..:..||||.|..:|:.: |.. ..|.||.|.:.         ..||.:.
Worm   594 ---TCGC---TKGACTSDMDCLNRALRVQCSSD-CSV-PYCSNRRFWKEDCGNKLCVSNGPRSKR 650

  Fly  1239 VYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGP 1303
            |...:    :..|    .|:|:.||.||||...:.|.:..|   |||..  .:.:.....:||..
Worm   651 VLKTK----IARR----AGEFLCEYAGEVITREQAQEKFAQ---DRDPR--IIAIAAHLFVDATK 702

  Fly  1304 KGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAK 1368
            :.|:|||:.|||:||...:.|:||..:|.|:||:.|:..|:|:|.:.  .||: ....||.|||.
Worm   703 RSNIARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDK--SDLL-PFDMACNCGAT 764

  Fly  1369 RCSGEIGG 1376
            .|...|.|
Worm   765 ECKRVIRG 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898
		PHD2_NSD	867..932	CDD:277040	9/68 (13%)
		PHD3_NSD	933..988	CDD:277041	7/54 (13%)
		PHD4_NSD	1001..1041	CDD:277042	2/39 (5%)
		WHSC1_related	1047..1141	CDD:99899	21/136 (15%)
		AWS	1183..1233	CDD:197795	15/58 (26%)
		SET	1234..1354	CDD:214614	39/119 (33%)
lin-59	NP_491206.1	AWS	591..636	CDD:197795	16/53 (30%)
		SET	638..748	CDD:214614	39/122 (32%)
		PHD	970..1027	CDD:279022
		BAH_polybromo	1118..1222	CDD:240068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940