DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NSD and set2

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_594980.1	Gene:	set2 / 2542070	PomBaseID:	SPAC29B12.02c	Length:	798	Species:	Schizosaccharomyces pombe

Alignment Length:	265	Identity:	89/265 - (33%)
Similarity:	133/265 - (50%)	Gaps:	30/265 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1122 QLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLST 1186
            |||.:..:..::|      :....:.|:.:..|.|...||      .|:|:             .
pombe    89 QLFHHLDSAKDKA------LTTFEEIQECQYASANIGKPP------ENEAM-------------I 128

  Fly  1187 CNCLP--VD--EHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFG 1247
            |:|.|  ||  ...||..:.|:|||...||..|....|..|:|:.|::.:..:::|....::|||
pombe   129 CDCRPHWVDGVNVACGHGSNCINRMTSIECTDEDNVCGPSCQNQRFQRHEFAKVDVFLTEKKGFG 193

  Fly  1248 LVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMN 1312
            |.....:....||.||:||||...:|::||.|...:..:::||:.::|...|||..:|:||||.|
pombe   194 LRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258

  Fly  1313 HSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGK 1377
            |||.|||...||.|....|:|||..:||....||||:|. .|......:.|:||...|.|.||||
pombe   259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYN-VDRYGAQAQPCYCGEPCCVGYIGGK 322

  Fly  1378 LKDDA 1382
            .:.:|
pombe   323 TQTEA 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898
		PHD2_NSD	867..932	CDD:277040
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042
		WHSC1_related	1047..1141	CDD:99899	4/18 (22%)
		AWS	1183..1233	CDD:197795	18/53 (34%)
		SET	1234..1354	CDD:214614	49/119 (41%)
set2	NP_594980.1	AWS	125..179	CDD:197795	19/66 (29%)
		SET	180..303	CDD:214614	50/123 (41%)
		SET	275..791	CDD:225491	22/54 (41%)
		PostSET	304..320	CDD:214703	5/15 (33%)
		Med26	440..489	CDD:285873
		SRI	699..771	CDD:285448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	105	1.000	Domainoid score	I1701
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040