DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and cti6

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_595212.1	Gene:	cti6 / 2539769	PomBaseID:	SPBC1685.08	Length:	424	Species:	Schizosaccharomyces pombe

Alignment Length:	514	Identity:	97/514 - (18%)
Similarity:	160/514 - (31%)	Gaps:	181/514 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDD 139
            :.:.||.||.|.||::   :||                                 ||.      |
pombe     3 SNSTPANEEKEEESEK---IQK---------------------------------SPV------D 25

  Fly   140 TIRTTRRRVNQAAALNNSSAGETL--------AHDNASPRTPGGGGG-----------------G 179
            |..|....|:.......||.||..        :.|.||      .||                 |
pombe    26 TPHTPNGSVSDNEENETSSTGEVTRCVCGIVESDDEAS------DGGLYIQCDQCSVWQHGNCVG 84

  Fly   180 GGDDS----------ANQLLSKTYM--------------SPIEKLLIKNGASSPNSTGFEAGSED 220
            ..|:|          .:....|.|.              .|||....:..:|:|.|
pombe    85 FADESEVPEVYYCEICHPEFHKVYQRGRGAKQSKYLGNGKPIEASQTEESSSTPPS--------- 140

  Fly   221 LGIRPIVRKHVKRKM------------KRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTD 273
                |..:|..|:::            :.:..||....:..:::.....||:           :.
pombe   141 ----PATKKSSKQRLTMNSRDAALDYEEYLAIAKEKSLIPRRSRGRTSSKSL-----------SP 190

  Fly   274 EAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEE 338
            .||..|:|.|.|::|.:.|.|:...::...:.:|.   :..|....:|::..|:.|::....|.|
pombe   191 PAPQDESQGTEINLKQKIEEENDEILEDSKESKDE---NEENKETSTTNVAETDAPEEETVDTVE 252

  Fly   339 LAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKV 403
            ........|..|...::.|..|..:..||| |.::.|...||..:...|.       .||
pombe   253 EIADEEKHSVKEESGEASPQSSQQSTITSI-STTTRSTRKAKREAAAEDK-------ADL----- 304

  Fly   404 FSYCFWPCMVCPDP-----LGQIVGNMPS---------HPQRSSLDNANVPIQVHVRFFADNGRR 454
                  |..|.|.|     :|...|...|         ||..:.::....|..:|.|......||
pombe   305 ------PAAVAPKPSKTRKVGGRRGKSSSNDNHRIPQLHPDGTFVETITKPKGLHSRITMTEMRR 363

  Fly   455 NWIKPENLLTFAG-------LKAFDDMREELRIKHGPKSAKYR-QMVPKRTKVVI-WRQ 504
               :..::|.:.|       .::..:.......|.||:..|.. :||...|:.:: |.|
pombe   364 ---RVASMLEYIGHIQVEMAAQSAGNQSSTKSSKEGPEEEKETLRMVDNLTRDLLHWEQ 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	27/137 (20%)
		PHD2_NSD	867..932	CDD:277040
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042
		WHSC1_related	1047..1141	CDD:99899
		AWS	1183..1233	CDD:197795
		SET	1234..1354	CDD:214614
cti6	NP_595212.1	PHD_SF	50..100	CDD:304600	8/55 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030