back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and SPCC645.13

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001342882.1	Gene:	SPCC645.13 / 2538700	PomBaseID:	SPCC645.13	Length:	721	Species:	Schizosaccharomyces pombe

Alignment Length:	749	Identity:	141/749 - (18%)
Similarity:	239/749 - (31%)	Gaps:	225/749 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LCNSASDSLTAT------DEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQP 79
            :|:|.||..:..      ||.....|...:.||:      :.||..         .|.|.:.::.
pombe    65 VCHSRSDVSSQVQNSPNKDEEHQTADLLASNEGN------EKNNEE---------NNVVSSDSKE 114

  Fly    80 A-AEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRT 143
            | .:||..|.:...|.  .....|.|..|.    ..||..:|  ||     |.||.|.....  :
pombe   115 AITKESGAELESSEPA--STNSNVGMTTRS----GRQSPRTP--IG-----STTPKSSHSPP--S 164

  Fly   144 TRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQ-------------------LL 189
            ||:|        ..|.|.|..|...|...|........:::|:|                   .:
pombe   165 TRKR--------RGSVGTTATHTKRSKNAPKTSPKDASNETADQEKELSLHTSIDEIQNPVRKSV 221

  Fly   190 SKTYMSPIEKLLIK------NGASSPNSTGFEAGSE-----------DLGIRPIVRKHVK-RKMK 236
            :|.::|..||::.|      .|....|||......|           |..:.|..:...| |.::
pombe   222 AKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVLSYTTDHSLTPNNKYREKFRALR 286

  Fly   237 -------------RVPKAKVTL-ELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISI 287
                         ||.|.:::. :|...:.:|:....:|.  :.||:.:      |..:.|.|.
pombe   287 FNLVDDKNPAFRARVLKNEISFNDLVNLSSEEMANPDLKN--LAEEIRQ------QSTENTVIK- 342

  Fly   288 KSETEAEHKAAVDVHIKQEDTI----RLDIVNN--------PVESTS-IVITEEPKDLEKSTEEL 339
                  :|..|....:..||.:    .|.|..|        |.|..: |.|.||...::..:..|
pombe   343 ------QHLIAPRDRLLDEDKLTQQDELGIAENDDAMFPKPPGELVAPISIAEEEPTIDSKSPTL 401

  Fly   340 AFALPLA----SSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFW 400
            ....||:    |:.:...|.....:.|....::  ||.|.||....|.||.:
pombe   402 PEHNPLSEDDTSNGDKAAKRKGSFNDTKPIVNV--PSIVEIDDPTILDIVEE------------- 451

  Fly   401 GKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTF 465
                           :||.:  .:..|.|...:.|.|.     ...||... .:.|.....:.|.
pombe   452 ---------------EPLAR--NDSFSSPYSPAEDMAE-----ESEFFGMK-EKIWTGKVKMATV 493

  Fly   466 A-----GLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAI---------------EEAQ 510
            :     .|..|.|:           ||.:...:...|.::..|.::               :|..
pombe   494 SEFHANALNLFGDV-----------SASHLFEILSATALIEGRISVSSVLQYFHALRKTPSKEII 547

  Fly   511 AMTQIPYSDRLEKFYQTYENVVTLNR-----QKRKRTK--YMMQDTSDVGSSLYDSTDNLHNKQG 568
            |:..:|.....:.|...|:..|..||     .|....|  |::...|  |:|:.:..|.|..
pombe   548 AVLFVPTEQNSQGFDILYDYFVKRNRYGVLHSKSNSVKDAYIIPMPS--GNSVPELLDLLPK--- 607

  Fly   569 TQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYE 633
               :.:.::|:...|...|    ..|:..::...:...|...|.:|.:..|......|..:..:.
pombe   608 ---VDLPKDRNFQYFMGLF----VLNKSSSRHESVERATPITTSTNGIPSTYQSASGTPTNPVHS 665

  Fly   634 NPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSN 667
            .|....:::|:....|:         ::..||.|
pombe   666 YPSLESIINALTPSDML---------LIKDVVEN 690

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.