DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and Phf20l1

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_006520979.1	Gene:	Phf20l1 / 239510	MGIID:	2444412	Length:	1018	Species:	Mus musculus

Alignment Length:	1152	Identity:	213/1152 - (18%)
Similarity:	343/1152 - (29%)	Gaps:	464/1152 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 KPENL--LTF---AGLKAFDDMR-------EELRIKHGPKSAKYRQMVPKRTKVVIW---RQAIE 507
            ||.|.  :||   |.|:|.|.::       |::..:.|.....:.:...:..:.:.|   |....
Mouse     4 KPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPL 68

  Fly   508 EAQAMTQIPYSDRLEKF-YQTYENVV--------------TLNRQ---------------KRKRT 542
            |..|:.:....|..|.| ::..|.|:              .:|::               ||...
Mouse    69 ERPALRKEGLKDEEELFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHI 133

  Fly   543 KYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSES---PFSPAFS---------------- 588
            |.|.:|.                 :|..|..||.:...|   |..||.|
Mouse   134 KAMPEDA-----------------KGQFLFQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKA 181

  Fly   589 --PVKSKNEKRAKRRKLSNGT---EADTG-----------SNSMAVT---------PSQTET--- 625
              ...:||:...|.|..:|..   |.|.|           :::..||         |:.:||
Mouse   182 AAAAAAKNKTGTKPRASANSNKEKERDGGKWFKLPSKKAETSTCIVTAEIEKKEELPTSSETFVG 246

  Fly   626 ----TVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASG 686
                ||....:..|          |..:.|:....        ..|.:..|:.:|.::...|||
Mouse   247 LHIDTVPKIVFPQP----------ESTLTNKRKNN--------QGNSFQAKRARLNKITGLLAS- 292

  Fly   687 EIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRR---LSEPPKTK 748
                        :..||...:|..:...|       .||:..:.:|.|....:.   :|....|:
Mouse   293 ------------KAVGVDGAERKEDCSAT-------APVLEQAISPKPQSQKKNEAVISSSANTQ 338

  Fly   749 KPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERK---- 809
            ||.             |.|..|..|.:|...||  :::| :...|.:|..|.|..:.::.|
Mouse   339 KPA-------------LLSSTLSSGKARSKKCK--HESG-ESSGCIKTPKSPLAPELIQAKDLTL 387

  Fly   810 ---------VTGAPMPKIGSRKALVIPP--------------TSKSPSPDEDHVTADAKEVVAVG 851
                     .|.:|.|        |.||              .:..|.||      |:.|.::..
Mouse   388 VSQLSSVINKTSSPQP--------VNPPRPCKHSERRRRSQRLATLPMPD------DSLEKLSSS 438

  Fly   852 TSLVCHECNVGEPEG---CVICHQVESPAVPSTPRKEDSSSHTPIEDKL-------LTCSQPMCG 906
            :|..         :|   .:.....:..:||..|    :.::.|:: ||       |:|...:.|
Mouse   439 SSAT---------DGKAFSISSQNQQQSSVPEVP----AIAYVPLQ-KLGPCLPLDLSCGSEVTG 489

  Fly   907 KRFHTSCCKYWPQASSSKHSARCPRHVCH---------TCVSDDPSGKFQQLGSSKLAKCV---- 958
            .|          ....|.|...|||....         :.|..|..|.....|.||..|.|
Mouse   490 SR----------TPHPSYHGGECPREEKEETPLFANPTSKVVSDVKGAAAATGISKTEKKVKLEE 544

  Fly   959 --------------------------------------------------------RC--PATYH 965
                                                                    ||  |.|..
Mouse   545 KTSTAFGKRKEKDKEKKEKRDKDHYKPKQKKKKKKKKKSKQHDYSDYEDSSLDFLERCSSPLTRS 609

  Fly   966 QLSKCIPAGTQMLNTTNIICPR---------HNIA------------------------------ 991
            ..|...|..|....||....||         .|::
Mouse   610 SGSSLAPRSTFTEKTTTYQYPRAILSVDLSGENLSDVEFLDDSSTESLLLSGDEYNQDFDSTNFE 674

  Fly   992 ----KADAHVNVLWCYIC---VKGGELVCCETCPIAVHAHCR-----NIPIKTNESYICEECESG 1044
                :.||...::.| ||   .:.|.::.||.|....|:.|.     :||    |.|||..|...
Mouse   675 ESQDEDDALNEIVRC-ICELDEENGFMIQCEECLCWQHSVCMGLLEDSIP----EQYICYICRDP 734

  Fly  1045 RLPLYGEIVWAKF-------NNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHD--HG-- 1098
            .    |:...||:       ||.|.:....|.......| .||....:..:...:|..:  ||
Mouse   735 P----GQRWSAKYRYDKEWLNNGRMYGLSFLKENYSHLN-AKKIVSTHHLLADVYGVTEVLHGLQ 794

  Fly  1099 ---WISRRRVY--LYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKL 1158
               .|.:.:.:  |::...:|   |.|.|     ...|.||.|       :...||.....|.:.
Mouse   795 LKIGILKNKHHPDLHLWAYSG---KRKDQ-----DQAVAEAER-------KITPQDRANSEGKEC 844

  Fly  1159 ---HPPPYVKIK------TNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCL-----NRMLF 1209
               |..|.::::      .:....|..|||:.:.|:.......|:.....|.|.|     :.:|:
Mouse   845 VQNHKEPALRMEETYITSEHSYQKPQSFSQDCQSLTDPGSSDDDDASSFEEDGELRVPDKSHLLY 909

  Fly  1210 -----NECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVIN 1269
                 :|.||   .:|    |::|          ||.:::|    ...|   ||..:::...::.
Mouse   910 KNRGVSEKNP---ASG----NKVF----------VYNDKKG----TEGP---GDSHLQWQLNLLT 950

  Fly  1270 HA-----EFQRRME--QKQRDRDENYYFLGVEKDFIIDAGPKGNLAR 1309
            |.     |...||:  :|:.|..|::.      ||..:..|...|||
Mouse   951 HIENVQNEVTSRMDLIEKEVDVLESWL------DFTGELEPPDPLAR 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	13/64 (20%)
		PHD2_NSD	867..932	CDD:277040	14/71 (20%)
		PHD3_NSD	933..988	CDD:277041	19/134 (14%)
		PHD4_NSD	1001..1041	CDD:277042	15/47 (32%)
		WHSC1_related	1047..1141	CDD:99899	23/109 (21%)
		AWS	1183..1233	CDD:197795	12/59 (20%)
		SET	1234..1354	CDD:214614	19/83 (23%)
Phf20l1	XP_006520979.1	MBT	3..68	CDD:388438	13/63 (21%)
		TUDOR	90..135	CDD:119391	5/44 (11%)
		PTZ00449	<320..511	CDD:185628	46/244 (19%)
		PHD20L1_u1	323..388	CDD:374703	17/80 (21%)
		PHD_PHF20L1	688..733	CDD:277103	16/49 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030