DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and Nsd3

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001074738.1	Gene:	Nsd3 / 234135	MGIID:	2142581	Length:	1446	Species:	Mus musculus

Alignment Length:	1369	Identity:	377/1369 - (27%)
Similarity:	569/1369 - (41%)	Gaps:	337/1369 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 PIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKS 289
            |.|.:.|..|....|:.|:.:....:|.:|:.|.|:..:.::|         .|.::.|....:|
Mouse   147 PSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNE---------VQASEHTKSKHES 202

  Fly   290 ETEAEHKAAVDVHIKQED-------TIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLAS 347
            ..|...|:......:.|:       .:..:..|.|.|... ...|:|:: |...:|.....|:.|
Mouse   203 RKEKRKKSNRHESSRSEERRSHKIPKLEPEGQNRPNERVD-TAPEKPRE-EPVLKEAIPVQPILS 265

  Fly   348 STEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCM 412
            |          :.:|..:|.:|                       :|||||.|.||.:|.:||||
Mouse   266 S----------VPTTETSTGVK-----------------------FQVGDLVWSKVGTYPWWPCM 297

  Fly   413 VCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREE 477
            |..||..::...:.:...|          :.||:||::...|.|:..:.:..:.|.:.::::..|
Mouse   298 VSSDPQLEVHSKINTRGAR----------EYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAE 352

  Fly   478 L---RIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKF-------------YQ 526
            .   ...|..|. |.|:..|:|.:.. |...|..|:...::...:|:|::             .|
Mouse   353 AAKQASNHSEKQ-KIRKPRPQRERAQ-WDIGIAHAEKALKMTREERVEQYTFIYIDKQPEEASSQ 415

  Fly   527 TYENVVT---LNRQKRKRTKYMMQ----DTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFS 584
            ..:||.:   :.:.:|.|:....|    :..:|.|| ..|||   .::.:|......|..|.|
Mouse   416 AKKNVTSKTEVKKPRRPRSVLNSQPEQTNAGEVASS-QSSTD---LRRQSQRRHTSLEEEEPP-- 474

  Fly   585 PAFSPVKSKNEKRAKRRKL---------------------------------------------- 603
                |||...:..|.|:.|
Mouse   475 ----PVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS 535

  Fly   604 ----SNGTEADT-GSNSMAV-TPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRS------DEK 656
                .|.||... |.:.:.: :|||.......|| .:||.....:..:|.....||      .||
Mouse   536 TKGIGNKTEISVRGQDRLIISSPSQRSEKPAQSA-SSPEATSGSAGPVEKKQQRRSIRTRSESEK 599

  Fly   657 VEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTI----KRLSNRLMTMM 717
            ..:|:        ..|:|:..::|        ..|..|...|...|...|    |.|..|
Mouse   600 SAEVV--------PKKKIKKEQVE--------TAPQASLKTGLQKGASEISDSCKPLKKR----- 643

  Fly   718 VRRSMTPVVTPSTT-PAPSEPDRR-LSE-PPKTKKPVNRP---IEEVIEDILQLDSKYLFRGL-- 774
             .|:.|.|.|.|.| ...|:.|.| ||: .....|.|:.|   .:....|...:||....||:
Mouse   644 -SRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDSSLSRRGVGT 707

  Fly   775 -SREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDED 838
             .::.:|:.|.:||..||.|...|....|.:||  .:|..|                      |.
Mouse   708 SKKDTVCQVCEKAGDCLVACEGECCRHFHVECL--GLTAVP----------------------EG 748

  Fly   839 HVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQP 903
            |.|              |.||..|: ..|..| :|....|.                   .||..
Mouse   749 HFT--------------CEECETGQ-HPCFSC-KVSGKDVK-------------------RCSVS 778

  Fly   904 MCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLS 968
            :|||.:|.:|.:.:|.|.......|||:|.|.:|..:.   ...:....::.:|:|||..||...
Mouse   779 VCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEK---DIHKASKGRMMRCLRCPVAYHVGD 840

  Fly   969 KCIPAGTQMLNTTNIICPRHN-IAKADAHVNVLWCYICV-------------------------- 1006
            .|:.||:..:::..:||..|: .:...|.:||.:|::|.
Mouse   841 ACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSE 905

  Fly  1007 -----------------------KGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPL 1048
                                   |||.|:|||:||.:.|..|.:|.:... .:.|.:|::|:...
Mouse   906 SNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEG-CWNCNDCKAGKKLH 969

  Fly  1049 YGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDT 1113
            |.:|||.|..|:|||||.|..|..||.||....|...||.|.|||:||:.|:.:.||:.|:|||.
Mouse   970 YKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK 1034

  Fly  1114 --GDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQ---DMERQSGNKLHPPPYVKIKTNKAVP 1173
              .:|..:.::.|:.   .:|||::....:||:|:.:   :|||.|..   ||||..||.||.:.
Mouse  1035 HFAEGQTSINKTFKK---ALEEAAKRFQELKAQRESKEALEMERTSRK---PPPYKHIKANKVIG 1093

  Fly  1174 PLRFS-QNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLE 1237
            .::.. .:|.::..|||.|.||:|||.|:.|||||...||:|:.|.||..|:|:.|.:|..|..|
Mouse  1094 KVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAE 1158

  Fly  1238 VVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAG 1302
            |:....||:||..:..|..|:||.|||||:|:..|.:.|:::...:...|:|.|.|.||.|||||
Mouse  1159 VIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAG 1223

  Fly  1303 PKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGA 1367
            ||||.:|||||||.|||||||||||...|||:||:.|||...||||||.. |.:.|.:..|.|||
Mouse  1224 PKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNL-DCLGNGRTVCHCGA 1287

  Fly  1368 KRCSGEIGGKLKDDAVKA------HAKLKQMRRAKASAVRIH---------------VKPKKTPK 1411
            ..|||.:|.:.|.....|      :||||:.|:.||.|..||               ...|..||
Mouse  1288 DNCSGFLGVRPKSACTSAVDEKTKNAKLKKRRKVKAEAKPIHEDYCFQCGDGGELVMCDKKDCPK 1352

  Fly  1412 VKHI 1415
            ..|:
Mouse  1353 AYHL 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	33/119 (28%)
		PHD2_NSD	867..932	CDD:277040	16/64 (25%)
		PHD3_NSD	933..988	CDD:277041	13/54 (24%)
		PHD4_NSD	1001..1041	CDD:277042	15/88 (17%)
		WHSC1_related	1047..1141	CDD:99899	38/95 (40%)
		AWS	1183..1233	CDD:197795	25/49 (51%)
		SET	1234..1354	CDD:214614	66/119 (55%)
Nsd3	NP_001074738.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..257		12/67 (18%)
		MSH6_like	277..393	CDD:99898	35/150 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..377		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..476		16/74 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..705		42/177 (24%)
		PHD_SF	713..755	CDD:304600	17/79 (22%)
		PHD2_NSD3	761..807	CDD:277122	16/65 (25%)
		PHD_SF	808..860	CDD:304600	13/54 (24%)
		PHD4_NSD3	927..962	CDD:277128	13/35 (37%)
		WHSC1_related	968..1061	CDD:99899	38/95 (40%)
		AWS	1104..1154	CDD:197795	25/49 (51%)
		SET	1155..1278	CDD:214614	67/123 (54%)
		PHD5_NSD3	1332..1374	CDD:277131	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5045
eggNOG	1	0.900	-	-		E2759_KOG1081
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1501
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38976at33208
OrthoFinder	1	1.000	-	-		FOG0001511
OrthoInspector	1	1.000	-	-		otm42471
orthoMCL	1	0.900	-	-		OOG6_102558
Panther	1	1.100	-	-	LDO	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900