Protein Alignment NSD and EZH2

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_011514185.1
• Gene: EZH2 / 2146
• HGNCID: 3527
• Length: 759
• Species: Homo sapiens
• Alignment Length: 948
• Identity: 177/948 - (18%)
• Similarity: 297/948 - (31%)
• Gaps: 326/948 - (34%)

  Fly   500 VIWRQAIE-EAQAMTQIPYSDRLEKFYQTYE--NVVTLNRQK-RKRTKYMMQDTSDVGSSLYDST 560
            |.||:.:: |...:.|      |::|.:..|  ::.:.|||| .:||:.:.|:............
Human    21 VCWRKRVKSEYMRLRQ------LKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHIL 79

  Fly   561 DNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTP----- 620
            .::.:.:||:..:|   .|:..|.....|:|:                    .|::|..|
Human    80 TSVSSLRGTRECSV---TSDLDFPTQVIPLKT--------------------LNAVASVPIMYSW 121

  Fly   621 --------SQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKV----------EKVLLSVVSN 667
                    .:.||.:.:..|...|........:|.::.| .|.||          :::.:.:|:.
Human   122 SPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKN-YDGKVHGDRECGFINDEIFVELVNA 185

  Fly   668 IWSL--------------KQIQLRELE-----------RDLASGEIEEPLGSSVVGRGSGVGTIK 707
            :...              ::.:.::||           |...|.:|.|.:.|....:    ||.:
Human   186 LGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDK----GTAE 246

  Fly   708 RLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFR 772
            .|..:... :..:.:...:.|..||....|:         .|.|.|  |:.:.....|..:..|:
Human   247 ELKEKYKE-LTEQQLPGALPPECTPNIDGPN---------AKSVQR--EQSLHSFHTLFCRRCFK 299

  Fly   773 ---GLSREPICKYCYQAGSDLVR------------CSRTCSSWLH-----ADCLERKVTGAPMPK 817
               .|.|:  |.|.:.|..:..:            |...|...|.     |..|..:....|..:
Human   300 YDCFLHRK--CNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKR 362

  Fly   818 IGSRKALVIPPTSKSPSPDEDHV--TADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPS 880
            .|.|:...:|..|..||....:|  :.|.......||. ...|.|..|.|        |.....|
Human   363 PGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTE-TGGENNDKEEE--------EKKDETS 418

  Fly   881 TPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGK 945
            :..:.:|...|||:.|      |......:..    |..|.:|........:..:.|
Human   419 SSSEANSRCQTPIKMK------PNIEPPENVE----WSGAEASMFRVLIGTYYDNFC-------- 465

  Fly   946 FQQLGSSKLAKCVRCPATYH----QLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICV 1006
                ..::|.....|...|.    :.|...||..:.::|.    ||....|     :.||.
Human   466 ----AIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTP----PRKKKRK-----HRLWA---- 513

  Fly  1007 KGGELVCCETCPIAVHAHCRNIPIK----TNESYICEECESGRLPLYGEIVWAKFNNFRWWPAII 1067
                            ||||.|.:|    :|..|..:.|:..|.|.....
Human   514 ----------------AHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSC--------------- 547

  Fly  1068 LPPTEVPSNILKK-----AHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNY 1127
              |..:..|..:|     :..:|.|                           .|.:.|:|
Human   548 --PCVIAQNFCEKFCQCSSECQNRF---------------------------PGCRCKAQ----- 578

  Fly  1128 TTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPV 1192
                                                                       ||   .
Human   579 -----------------------------------------------------------CN---T 581

  Fly  1193 DEHPCGPEAGCLNRMLFNECNPEYC-KAGSL---------CENRMFEQRKSPRLEVVYMNERGFG 1247
            .:.||        .:...||:|:.| ..|:.         |:|...::.....|.:...:..|:|
Human   582 KQCPC--------YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWG 638

  Fly  1248 LVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMN 1312
            :..::|:...:|:.||.||:|:..|..||  .|..|:....:...:..||::||..|||..||.|
Human   639 IFIKDPVQKNEFISEYCGEIISQDEADRR--GKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 701

  Fly  1313 HSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNY 1350
            ||..|||..:...||..||:||||.:.|....||.|:|
Human   702 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	4/14 (29%)
		PHD2_NSD	867..932	CDD:277040	11/64 (17%)
		PHD3_NSD	933..988	CDD:277041	9/58 (16%)
		PHD4_NSD	1001..1041	CDD:277042	9/43 (21%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	8/99 (8%)
		AWS	1183..1233	CDD:197795	11/59 (19%)
		SET_NSD	1233..1375	CDD:380950	43/118 (36%)
EZH2	XP_011514185.1	EZH2_WD-Binding	47..76	CDD:463308	7/28 (25%)
		PRC2_HTH_1	166..257	CDD:436286	11/95 (12%)
		preSET_CXC	572..603	CDD:408079	11/105 (10%)
		SET_EZH2	622..741	CDD:380995	43/120 (36%)