DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and Ash1l

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_619620.3	Gene:	Ash1l / 192195	MGIID:	2183158	Length:	2958	Species:	Mus musculus

Alignment Length:	1885	Identity:	381/1885 - (20%)
Similarity:	623/1885 - (33%)	Gaps:	645/1885 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SEIEGDAAHGNVLCNSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPV-RLLDKPGQNP 72
            |:...::.|.||...|...||            |:..:|.|.|:....|....: |:....|:.|
Mouse   601 SQFTAESTHLNVGHRSLGHSL------------SIECKGIDKELNESKNTHLDIPRISSSLGKKP 653

  Fly    73 ---------------------------VQNGAQPAAE------ESELESQRQTPVQKQQQQRVSM 104
                                       ::.||..|.:      ||...|.:..|::|::.::...
Mouse   654 SLTSDSGIHAITPSVVNFTSLFSNKPFLKLGAVTAPDKHCQVAESLSSSFQSKPLKKRKGRKPRW 718

  Fly   105 VNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSS----------A 159
            .               |.:..:...||..|    |..|:...:....::|:|||          |
Mouse   719 T---------------KVVARSTCRSPKGL----DLERSELFKNVSCSSLSNSSEPAKFMKTIGA 764

  Fly   160 GETLAHDNASPRTPGGGGGGGGD-----DS-------------------ANQLLSKTY------- 193
            ...:.||....|.|.........     ||                   .:.|||..|
Mouse   765 SSFVDHDFLKRRLPKLSKSSAPSLALLTDSEKPSHKSFITHKLSSSMCVTSDLLSDIYKPKRGRP 829

  Fly   194 ----MSPIE---KLLIKNGASSPNSTGFEAGSE---------------DLGIRPIVRK--HVKRK 234
                |..:|   |..:|..||...|...:...|               .|.:.|..:|  ..||:
Mouse   830 KSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKRQ 894

  Fly   235 MKRVPKAK---------VTLELDEKNQQEVDEKSVKTE--PIDEEVDRTDEAPTQEAQTTAISIK 288
            |:...|.|         |..|...|.:.|.:.....::  ..::::..||:......|:......
Mouse   895 MRSPVKMKPPVLSVAPFVATESPSKLESESENHRSSSDFFESEDQLQDTDDLDDSHRQSVCSMSD 959

  Fly   289 SETEAEHKAA----------VDVHIKQEDTIRLDIVNNPVESTSIVITEEPK---DLEKSTEELA 340
            .|.|.:.|.:          :...|.:..|::...:.|.:.|:|:..:.:.|   .|..:...||
Mouse   960 LEMEPDKKISKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLA 1024

  Fly   341 --FALPLASSTEVDLK-----------SPPDLSSTALATSIKSPSSVSI-----DSAKG--LSIV 385
              |...|.....|..|           .|..:.:..|:   .||:|:::     ..|.|  |..:
Mouse  1025 ATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGLLS---GSPASLAVLEQTAQQAAGSALGQI 1086

  Fly   386 TDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVP-IQVHVR--- 446
            ..|..|:         ...|....|..:|....|...|..|.......::.::|| :.||.|
Mouse  1087 LPPLLPS---------PASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHVHSRQGS 1142

  Fly   447 -------FFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQ 504
                   ..|..|||. :.|..||..:.             .|..:....::..|         .
Mouse  1143 MIQTLAMKKASKGRRR-LSPPTLLPNSP-------------SHLSELTSLKEATP---------S 1184

  Fly   505 AIEEAQAMTQIP-----------YSDRLEKFYQTYENVVTLNRQKRKRTKY-----MMQDTSDVG 553
            .:.|:.:...||           .|||.|||.          .||::|..:     :..:||.|.
Mouse  1185 PVSESHSDETIPSDSGIGTDNNSTSDRAEKFC----------GQKKRRHSFEHISLIPPETSTVL 1239

  Fly   554 SSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRK---LSNGTEADTGSNS 615
            :||.:...:...::....|:..               |.|.:||.:::|   |.|..:.|..:
Mouse  1240 NSLKEKHKHKCKRRSHDYLSYD---------------KMKRQKRKRKKKYPQLRNRQDPDFIA-- 1287

  Fly   616 MAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNI------------ 668
                                |..:|:|.:.|..:.:||...:.:.||..:..|
Mouse  1288 --------------------ELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFP 1332

  Fly   669 ---------WSLKQIQLRELERDLASGE------IEEPLGSS--------------VVGRGSGVG 704
                     ..||:.:.|..:...|..|      :..||.|:              :.....|:|
Mouse  1333 LDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLG 1397

  Fly   705 TIKRLSNRLMTMMVRRSMTPVVTPS-TTPAP----SEPDRRLSEPPKTKKPVNRPIEEVIEDIL- 763
            ...|....|        ..|..:|| |||.|    ......|..|.|..|..::.:.:  |..|
Mouse  1398 YYGRYPPTL--------YPPPPSPSFTTPLPPPSYMHAGHLLLNPTKYHKKKHKLLRQ--EAFLT 1452

  Fly   764 -----------------------QLDSKYLFR-----------------GLSR---EPICKYCYQ 785
                                   .::.|:..|                 |.||   |.:.:|.:
Mouse  1453 TSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSEQPQVSMDSGSSRSVLESLKRYRF- 1516

  Fly   786 AGSDLV----------RCSRTC-------------SSWLHADCLERKVTGAPMPKIGSRKALVIP 827
             |.|.|          ||..:|             ..|     :.|:.:.:....:|.:..|.|.
Mouse  1517 -GKDTVGDRYKHKEKHRCHMSCPHLSPSKNLINREEQW-----VSREPSESSSLALGLQTPLQID 1575

  Fly   828 PTSKSPS-------PDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQ----------VES 875
            .:..|||       |:.:..::|  |.:.:.||.: ..|.|..|...  |.:          |:.
Mouse  1576 CSESSPSLSLGGFTPNSEPASSD--EHMNLFTSAI-GSCRVSNPNSS--CRKKLTDSPGLFPVQD 1635

  Fly   876 PAVPSTPRKED-SSSHTPIEDKLLTCSQPMCGKRFH-----TSCCKYWPQASSSKHS-------A 927
            .|:....|||. .||...|:.  |..||....|...     |:|.....::||...|       :
Mouse  1636 TALNRPHRKEPLPSSERAIQS--LAGSQSASDKPSQRSSESTNCSPTRKRSSSESTSSTVNGVPS 1698

  Fly   928 RCPR--------------HVCH---------------TCVSDDPS-------GKFQQLGSSKLA- 955
            |.||              .:.|               |.||..||       .|.:.||.|...
Mouse  1699 RSPRLVASMDDSVDSLLQRIVHHDEQESMEKNGDASITTVSAPPSSSPGHSYSKERALGKSDSLL 1763

  Fly   956 -------KCVRCP-ATYHQLSKCIP-------------AGTQMLNTTNIICPRHNIAKADAHVNV 999
                   .|...| .:....|:|.|             ...:|.|...|:..:.|:    .|||.
Mouse  1764 VPAVPNDSCSNIPLLSEKSASRCSPHHIKRSVVEAMQRQARKMCNYDKILATKKNL----DHVNK 1824

  Fly  1000 LWCYICVKGGELV---------------CCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLY 1049
            :     :|..:|.               ....||:......:........|....|.|...|.|.
Mouse  1825 I-----LKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVSPELNEGEDMSLHLS 1884

  Fly  1050 GEIV-------------------------W-----------------AKFNNFRWWPAIILPPTE 1072
            .:.|                         |                 .:.||    .:.|..|.|
Mouse  1885 PDTVTDVIEAVVQSVNLTSEHKKGVKRKNWLLEEQTRKKQKTVPEEEEQENN----KSFIETPVE 1945

  Fly  1073 VPSNI---LKKAHGENDF--VVRFFGTHDHGWISRRRVY----LYIEGDTGDGHKT---KSQLFR 1125
            :||.:   .:.:..||..  |:.............::.|    ||     .|.:||   ||:|.:
Mouse  1946 IPSPLETPAEPSEPENTLQPVLALIPREKKAPRPPKKKYQRAGLY-----SDVYKTIDPKSRLIQ 2005

  Fly  1126 ------NYTTGVEEASRF---LPIIKARRQEQ-DME-------RQSGNKLHPPP----YVKIKTN 1169
                  .||.|..|...|   :.:.|..||:: |.:       :...|:|:..|    |.||::|
Mouse  2006 LKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSN 2070

  Fly  1170 --KAVPPLRFSQNLEDLSTCNCLPVDEHP---CGPEAGCLNRMLFNECNPEYCKAGSLCENRMFE 1229
              ..|.||    :..:.:||||...|:..   ||.:  |||||:|.||:|..|..|..|.|:..:
Mouse  2071 VYVDVKPL----SGYEATTCNCKKPDDDTRKGCGDD--CLNRMIFAECSPNTCPCGEQCCNQRIQ 2129

  Fly  1230 QRKSPR-LEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGV 1293
            :.:..: ||.....|:|:|:..:||:..|.|:|||:|||::..||:.||.::..:..: :|.|.:
Mouse  2130 RHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSD-HYCLNL 2193

  Fly  1294 EKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNN 1358
            :...:||:...||.|||:||||:||||.|||:||.::|:|::|:||:|..:|||::|.:......
Mouse  2194 DSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVE 2258

  Fly  1359 SKKACFCGAKRCSGEIGGK-LKDDAVKAH------------AKLKQMRRAKASAVRIHVKPKKTP 1410
            .::.|.||.::|.|.|||| .:.:.:.:|            |:.|:.|::|....:....|.:.|
Mouse  2259 KQQLCKCGFEKCRGIIGGKSQRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEP 2323

Fly 1411 1410
Mouse 2324 2323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	21/127 (17%)
		PHD2_NSD	867..932	CDD:277040	21/101 (21%)
		PHD3_NSD	933..988	CDD:277041	18/98 (18%)
		PHD4_NSD	1001..1041	CDD:277042	5/54 (9%)
		WHSC1_related	1047..1141	CDD:99899	27/156 (17%)
		AWS	1183..1233	CDD:197795	20/52 (38%)
		SET	1234..1354	CDD:214614	51/120 (43%)
Ash1l	NP_619620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..580
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..843		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..963		16/85 (19%)
		motB	<1061..1187	CDD:183756	29/160 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1126		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1149..1219		18/102 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1279		7/50 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1599		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1613..1704		23/94 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1722..1754		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1921..1941		2/23 (9%)
		Catalytic domain. /evidence=ECO:0000250	2059..2278		87/225 (39%)
		AWS	2082..2133	CDD:197795	20/52 (38%)
		SET_ASH1L	2136..2276	CDD:380951	57/140 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2278..2334		7/46 (15%)
		Bromo_ASH1	2432..2537	CDD:99955
		PHD_ASH1L	2575..2617	CDD:277023
		BAH_polybromo	2654..2788	CDD:240068
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2814..2846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2861..2909
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940