Protein Alignment NSD and set-8

DIOPT Version :9

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_001359546.1
• Gene: set-8 / 184086
• WormBaseID: WBGene00008527
• Length: 407
• Species: Caenorhabditis elegans
• Alignment Length: 504
• Identity: 109/504 - (21%)
• Similarity: 179/504 - (35%)
• Gaps: 171/504 - (33%)

  Fly   929 CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPAT---YHQLSKCIPAGTQMLNTTNI-ICPR-- 987
            ||.|:|..|.::.    |:  .|:.|...:...:|   :|  |.|:|||....|...: :.||
 Worm     3 CPDHICEICFTEG----FE--SSATLGNLLHEQSTIRAFH--SSCMPAGYTEKNAGVVSLNPRIQ 59

  Fly   988 -----HNIAKADAHVNVLWCYIC-VKGGELVCCETCPIAVHAHCRNIPIK-TNESYI-CEECESG 1044
                 |..|          |..| .....::.|..|..:.|..|  .|:| |.||.. ||.|...
 Worm    60 EFLGTHFPA----------CGTCGTSTPPMIKCSGCVHSFHRAC--FPMKLTEESKSHCESCVFD 112

  Fly  1045 -RLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLY 1108
             |:.:..|::..|...|             .|.:::      |:....|...|..:
 Worm   113 IRMRIGDEVLTEKDEIF-------------CSGVIE------DWNQNHFAKQDENF--------- 149

  Fly  1109 IEGDTG------DGHKTK-----SQLFRNYTTGVEEASRFLPII--------KARRQE------- 1147
              |..|      ||..::     :.|||.|       ||...||        ....||
 Worm   150 --GKEGFASILFDGVGSRQILPINSLFRPY-------SRVTNIIFHSIKSMYNGHPQELENLKSM 205

  Fly  1148 -QDMERQSGNKLHPPPYVKIKTNKAVPPLR----FSQNLEDLSTCNCLPVDEHPCGPEAGCLNRM 1207
             |.:|.|     .||      .::.:|..:    |...:::| .|:
 Worm   206 LQKIESQ-----RPP------VSRPIPKFQSISIFHSTIKEL-LCH------------------- 239

  Fly  1208 LFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAE 1272
                 :.::......||:.:.:..|:          :|:|:...:.:..|..:.:|.||.|:..|
 Worm   240 -----DDDFLPNVKTCEDLLLKFEKN----------KGYGVFATKILENGCVIGQYCGEYISEKE 289

  Fly  1273 FQRR--MEQKQRDRDENYYFLGVEKDFI---------IDAGPKGNLARFMNHSCEPNCE--TQKW 1324
            ..||  :.:...|::..:|...|:.:.:         :|.....|:...:|.||||||.  .::.
 Worm   290 KARRDALAKVCNDKECKFYSFQVKLELLNELQAQKVYVDGSSVKNITAILNTSCEPNCTAIVEEI 354

  Fly  1325 TVNCIHRVGIFAIK---DIPVNSELTFNYLWDDLMNNSKKACFCGAKRC 1370
            ::..| |:....||   .|.|..|||.||.|     ||...||||:::|
 Worm   355 SIQNI-RIEYIVIKTKRTIKVGEELTINYKW-----NSSFKCFCGSEKC 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898
		PHD2_NSD	867..932	CDD:277040	2/2 (100%)
		PHD3_NSD	933..988	CDD:277041	15/65 (23%)
		PHD4_NSD	1001..1041	CDD:277042	13/42 (31%)
		WHSC1_related	1047..1141	CDD:99899	17/104 (16%)
		AWS	1183..1233	CDD:197795	4/49 (8%)
		SET	1234..1354	CDD:214614	34/135 (25%)
set-8	NP_001359546.1	SET	<106..400	CDD:225491	78/381 (20%)
		SET	251..389	CDD:214614	38/153 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1081
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810