DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and Nsd1

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_032765.3	Gene:	Nsd1 / 18193	MGIID:	1276545	Length:	2691	Species:	Mus musculus

Alignment Length:	1635	Identity:	439/1635 - (26%)
Similarity:	664/1635 - (40%)	Gaps:	367/1635 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ATDEVAAGNDESVATEGDD--VEIPRDTNNSTPVRLLDKPG-QNPVQNGAQPAAEESELESQRQT 92
            |.||....|..||:|..||  .::....:||         | ||.|. |...|.:::|    ...
Mouse   626 AGDEEKRSNSVSVSTTSDDGCSDLDPTEHNS---------GFQNSVL-GITDAFDKTE----NAL 676

  Fly    93 PVQKQQQQ--RVSMVNRKRD-------------LINLQSALSPKYIGYANAN-------SPTPLS 135
            .|.|.:.|  |..:.||.::             |:.....:.|:....:..|       ||.|..
Mouse   677 SVHKNETQYSRYPVTNRIKEKQKSLITNSHADHLMGSTKTMEPETAELSQVNLSDLKISSPIPKP 741

  Fly   136 DSD---DTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQ-LLSKTYMSP 196
            ..:   |.:.|            ..||...:.::|  |.|.||        .||| ||......|
Mouse   742 QPEFRNDGLTT------------KFSAPPGIRNEN--PLTKGG--------LANQTLLPLKCRQP 784

  Fly   197 IEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKA------KVTLELDEKNQQEV 255
            ..:.:......||......|.||||.::..........:..:.|:      |:...:.||.:...
Mouse   785 KFRSIKCKHKESPAVAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMHEKTRDSS 849

  Fly   256 D-EKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVE 319
            | |.:|....:.|..:.:..:.:::...:..:..|:......|:...||             |:|
Mouse   850 DIETAVVKHVLSELKELSYRSLSEDVSDSGTAKASKPLLFSSASSQNHI-------------PIE 901

  Fly   320 -----STSIVITEEPKDLEKSTEELAFALPLASSTEVD----LKSPPDLSSTALATSIKSPSSVS 375
                 ||.:::.::..|.:...:.|..|..|||....|    ....|..:|..|.....:|:|..
Mouse   902 PDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEK 966

  Fly   376 IDSAKGLSIVTDPGWPTYQV-GDL---------------FWGKVFSYCFWPCMVCPDPLGQIVGN 424
            ...:...|:...||.....: |:|               ..||:.|.|. |...|    |:.
Mouse   967 PGDSTQDSVHQSPGGGDSALSGELSSSLSSLASDKRELPACGKIRSNCI-PRRNC----GRA--- 1023

  Fly   425 MPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIK-----HGP 484
            .||...|.::....|...|:.:.         :|.|....|:.|.|.......|..|     :||
Mouse  1024 KPSSKLRETISAQMVKPSVNPKA---------LKTERKRKFSRLPAVTLAANRLGNKESGSVNGP 1079

  Fly   485 ---------KSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRK 540
                     |....:||...|.:...:.....:::|....| ...||| ..::||        ||
Mouse  1080 SRGGAEDPGKEEPLQQMDLLRNEDTHFSDVHFDSKAKQSDP-DKNLEK-EPSFEN--------RK 1134

  Fly   541 RTKYMMQDTSDVGSSLYDSTDNLHN------KQGTQLLAVKR-------------ERSESPFS-- 584
                    ..::||.:....|.||.      |:..|.|..:|             |.||..|.
Mouse  1135 --------GPELGSEMNTENDELHGVNQVVPKKRWQRLNQRRPKPGKRANRFREKENSEGAFGVL 1191

  Fly   585 -PAFSPVKSKN---EKRAKRRKLSNGTEADT--GSNSMAVTPS--------------QTETTVDS 629
             ||.:..|::.   |:||........:.||.  ||:|.:|.|.              :.||.:.|
Mouse  1192 LPADAVQKAREDYLEQRAPPTSKPEDSAADPNHGSHSESVAPRLNVCEKSSVGMGDVEKETGIPS 1256

  Fly   630 ----SAYENPEFRQ-----------LLSAVMEYVMM-------NRSDEKVEKV--------LLSV 664
                :....|..|.           ||....||..:       .:..|:|.||        ||:.
Mouse  1257 LMPQTKLPEPAIRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLAR 1321

  Fly   665 VSNIWSLKQ------IQLRE----LERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVR 719
            .......||      |..:|    |||:  :..:|.||..|.:|       :.......:|:.|
Mouse  1322 CQPSAQNKQVDENSLISTKEEPPVLERE--APFLEGPLAQSDLG-------VTHAELPQLTLSV- 1376

  Fly   720 RSMTPVVTPSTTPAPS-EPDRRLSEPPKT--KKPVNRPIEEVIEDILQLDSKYLFR----GLSRE 777
                 .|.|..:|.|: |.:..|.:.|..  .|...:|.::::|. ..||..::.:    ||||:
Mouse  1377 -----PVAPEASPRPALESEELLVKTPGNYESKRQRKPTKKLLES-NDLDPGFMPKKGDLGLSRK 1435

  Fly   778 PICKYCYQA---GSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPP----------- 828
                 |::|   |:.:|. ||..|..........|:...|..:  .|:.||...
Mouse  1436 -----CFEASRSGNGIVE-SRATSHLKEFSGGTTKIFDKPRKR--KRQRLVTARVHYKKVKKEDL 1492

  Fly   829 TSKSPSPDED---HVT-ADAKEVVAVGT-----------------------SLVCHEC-NVGE-- 863
            |..:||.:.:   |.| |..||::..|.                       ..||..| .:||
Mouse  1493 TKDTPSSEGELLIHRTAASPKEILEEGVEHDPGMSASKKLQVERGGGAALKENVCQNCEKLGELL 1557

  Fly   864 --PEGCVICHQVESPAVPSTPRKE--DSSSHTPIE---------DKLLTCSQPMCGKRFHTSCCK 915
              ...|.....:|...:|..||.:  .:..||.|.         :.:..|..|:|||.:|..|.:
Mouse  1558 LCEAQCCGAFHLECLGLPEMPRGKFICNECHTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQ 1622

  Fly   916 YWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNT 980
            .:|...:.....|||.|:|.||.:.:|:......|  :|.:|||||..||....|:.||:::|.:
Mouse  1623 KYPPTVTQNKGFRCPLHICITCHAANPANVSASKG--RLMRCVRCPVAYHANDFCLAAGSKILAS 1685

  Fly   981 TNIICPRHNIAKADA----HVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEEC 1041
            .:||||.|...:...    ||||.||::|.:||.|:||::||.|.|..|.||.|.....| |.:|
Mouse  1686 NSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWY-CNDC 1749

  Fly  1042 ESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVY 1106
            ::|:.|.|.||||.|...:|||||.|..|..|||||.|..|...:|.|.|||::|:.|..:.||:
Mouse  1750 KAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVF 1814

  Fly  1107 LYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKA 1171
            .|:|||.....|....:...|...::||:.....:||:::.:.::....|...||||..||.|:.
Mouse  1815 PYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRP 1879

  Fly  1172 VPPLR-FSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPR 1235
            :..:: |:.:|.::..|||...||:|||.::.|:||||..||:|..|.||..|:|:.|.:|:.|.
Mouse  1880 IGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPD 1944

  Fly  1236 LEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIID 1300
            :|:....:||:||..:..|..|:||.|||||:|:..|.:.|:...|.....|:|.|.::||.|||
Mouse  1945 VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIID 2009

  Fly  1301 AGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFC 1365
            ||||||.||||||.|:||||||||:||...|||:||:.||...:||||||.. :.:.|.|..|.|
Mouse  2010 AGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNL-ECLGNGKTVCKC 2073

  Fly  1366 GAKRCSGEIGGKLKDDAV-----------KAHAKLKQMRRAKASAVR---------------IHV 1404
            ||..|||.:|.:.|:..:           |.|.|    ||::....:               :..
Mouse  2074 GAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGK----RRSQGEVTKEREDECFSCGDAGQLVSC 2134

  Fly  1405 KPKKTPKVKH 1414
            |....|||.|
Mouse  2135 KKPGCPKVYH 2144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	27/146 (18%)
		PHD2_NSD	867..932	CDD:277040	19/75 (25%)
		PHD3_NSD	933..988	CDD:277041	21/54 (39%)
		PHD4_NSD	1001..1041	CDD:277042	18/39 (46%)
		WHSC1_related	1047..1141	CDD:99899	38/93 (41%)
		AWS	1183..1233	CDD:197795	23/49 (47%)
		SET	1234..1354	CDD:214614	63/119 (53%)
Nsd1	NP_032765.3	MSH6_like	320..430	CDD:99898
		TNG2	<1453..1587	CDD:227367	25/135 (19%)
		PHD1_NSD1_2	1546..1587	CDD:277118	10/40 (25%)
		PHD2_NSD1	1593..1639	CDD:277120	11/45 (24%)
		PHD3_NSD1	1640..1693	CDD:277123	21/54 (39%)
		PHD4_NSD1	1710..1749	CDD:277126	18/39 (46%)
		WHSC1_related	1755..1849	CDD:99899	38/93 (41%)
		AWS	1902..1940	CDD:375420	19/37 (51%)
		SET_NSD1	1942..2083	CDD:380987	72/141 (51%)
		PHD5_NSD1	2121..2163	CDD:277129	5/24 (21%)
		C5HCH	2162..2211	CDD:375464
		PHA03307	2255..>2576	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5226
eggNOG	1	0.900	-	-		E2759_KOG1081
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1501
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38976at33208
OrthoFinder	1	1.000	-	-		FOG0001511
OrthoInspector	1	1.000	-	-		otm42471
orthoMCL	1	0.900	-	-		OOG6_102558
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860