DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and set-5

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001256612.1	Gene:	set-5 / 179973	WormBaseID:	WBGene00008145	Length:	1558	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	191/1001 - (19%)
Similarity:	309/1001 - (30%)	Gaps:	388/1001 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQ--------NGAQPAAEESELESQRQTP 93
            |.:|...|.|.     |..|.|:  |.|.|.|.:.|.|        :||..::|:.:...:....
Worm   705 ASSDNPNAAEN-----PVSTQNT--VDLHDIPSKTPQQKVTSENRGSGAPNSSEDQQKLDEIAPT 762

  Fly    94 VQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVN--------- 149
            .|...:..||:.:|. |:..:.:..|.|.:|......... |.|::|: :.|.||:
Worm   763 TQILPEDPVSVQSRS-DVCEVTAETSQKSVGPERIGGDAQ-SSSENTV-SVRNRVDLHGIPSKTP 824

  Fly   150 QAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKN---------- 204
            |....:..||..:..:......||..           ::|||..:|...|..:|.
Worm   825 QKLVQSGKSAQSSTENQQQIEMTPEA-----------RILSKNPISAQSKTPVKEERPESHSLSE 878

  Fly   205 -----------GASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLE------------ 246
                       ...|.|||...:.|..:|:|.:       |::::|...:.:|
Worm   879 SFASTQHPMKISEISENSTQNRSDSSRIGLRSV-------KLEQIPSRTIKVEEPTDFPSNSEPE 936

  Fly   247 ----LDEKNQQEVDEKSVKTE-PIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQE 306
                |:.:..:..:..||:.| |||:|....||.|  |..|.......:.||::..|.|
Worm   937 AQIPLETRTLEPSEASSVQPEPPIDQEEAENDENP--EILTPNSPTIDQDEAQNSDAPD------ 993

  Fly   307 DTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALP-LASSTEVDLKSPPDLSSTALATSIKS 370
                               .....||.|...||...:. |...||       .:|..|:.|.|
Worm   994 -------------------ASADSDLPKLEPELERMIDFLVEITE-------KISVPAIKTDI-- 1030

  Fly   371 PSSVSIDSAKGLSIVTDPGWPTYQ-----------VGDLFWGKVFSYCFWPCMVCPDPLGQIVGN 424
                               |..||           :...|..|               |..|:
Worm  1031 -------------------WKLYQARMKQNVKEECIRQRFMSK---------------LAPII-- 1059

  Fly   425 MPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKY 489
                   ..|||.::..:|.:.|                 ...:|...|..:|||     |:|..
Worm  1060 -------HRLDNYSIEARVRIIF-----------------VLSVKVDADFLKELR-----KNAVV 1095

  Fly   490 R----QMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTS 550
            |    |::.|..........:|...:|     ||||               :.|||:..:::|
Worm  1096 RVDDEQLITKYVSCNDGGLKLEGNHSM-----SDRL---------------KNRKRSLDLIKD-- 1138

  Fly   551 DVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNS 615
                                   |..|:.|     |...||       |.:|.::|:|.||.:..
Worm  1139 -----------------------VDCEKKE-----AEHDVK-------KTKKSTSGSENDTDAEE 1168

  Fly   616 MAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDE----------KVEKVLLSVVSNIWS 670
               |...:.|.......||.|.|:..|:....::.:.|:|          |.||
Worm  1169 ---TDFHSITERQPKVVENSENRKRASSAKRRLVTSSSEESDQDDRSSRSKTEK----------- 1219

  Fly   671 LKQIQLRELERDLASGEIEEPLGSSV-----------VGRGSGVGTIKRLS----NRLMTMMVRR 720
                     :|.:|:.|......|.|           ...|......|:|:    |:....::|:
Worm  1220 ---------QRKIAANEKRSSTASRVRILSDSSDESNREEGPSCSNSKKLTKISGNKKNPAILRK 1275

  Fly   721 SMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQ 785
            .:.     ..:...|:.|.|.|.|...|:|      ::.|:          :..:.:|  |.|.
Worm  1276 RLL-----GDSSDKSDKDERTSCPSSKKRP------KLAEN----------KKNASQP--KRCL- 1316

  Fly   786 AGSDL-------VRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTAD 843
            :||::       ..||.|..        :.||       :.::|.   |||   |..:|:..|:|
Worm  1317 SGSNVKSDKNEKAGCSGTKK--------QEKV-------VKNKKK---PPT---PKANENTTTSD 1360

  Fly   844 AKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKR 908
            ...:          |.:..:.||..       |..|..|    .||..||   |...::|...:.
Worm  1361 HSRI----------ETDDIQFEGVY-------PIEPCAP----VSSGMPI---LSVKTEPRSTEH 1401

  Fly   909 FHTSCCKY----WPQASSSKHSARCP 930
            ...|   |    :.||..|..:..||
Worm  1402 LSFS---YENVAYTQAEFSSTTYACP 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	21/131 (16%)
		PHD2_NSD	867..932	CDD:277040	16/68 (24%)
		PHD3_NSD	933..988	CDD:277041
		PHD4_NSD	1001..1041	CDD:277042
		WHSC1_related	1047..1141	CDD:99899
		AWS	1183..1233	CDD:197795
		SET	1234..1354	CDD:214614
set-5	NP_001256612.1	SET	36..151	CDD:214614
		PHA03309	<793..1008	CDD:165564	48/261 (18%)
		SPK	1006..1118	CDD:214732	31/185 (17%)
		PTZ00108	<1115..1328	CDD:240271	57/316 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030