Protein Alignment NSD and set-16

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_499819.3
• Gene: set-16 / 176802
• WormBaseID: WBGene00011729
• Length: 2475
• Species: Caenorhabditis elegans
• Alignment Length: 1692
• Identity: 311/1692 - (18%)
• Similarity: 532/1692 - (31%)
• Gaps: 603/1692 - (35%)

  Fly    53 PRDTN-NST----PVRLLDKPGQNPVQN-------GAQPAA-----------------------E 82
            ||.|| .||    |.::..|...||..|       ..||..                       :
 Worm  1008 PRRTNVQSTDSPPPPQMGFKVPANPSSNMMGSSEQSMQPKQVFITHHLPMDVYQVYQDLKRVKFD 1072

  Fly    83 ESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGY---ANANSPTPLSDSDDTIRTT 144
            ...|....:..:.|.::|:.::..:||.::..|:| :|.|.|.   .|.:....|:...:.|:.|
 Worm  1073 RERLNGSLEEQLNKARKQKKNLAAKKRQMVKTQTA-APDYDGRNIDLNESDQQTLATLTEQIKVT 1136

  Fly   145 RRRV---NQAAALNNSSAGE------TLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKL 200
            :..:   .:....:.|:..:      .|.:::...|.         |...:.:..:.|.:..:::
 Worm  1137 QAEIELHRRDLKKHESNLSDFVMKHGILRNEHEVKRE---------DVQLSAIRDQQYAAHADEM 1192

  Fly   201 LIKNGASSPNSTGFEAGSEDLG-IRPIVRKHVKRKMKRVPKAKVTLEL---DEKNQQEVDEKSVK 261
            |.:           :|.::.|| :.|.|..        .|:|.::|.:   .:::.|.:.:..::
 Worm  1193 LAQ-----------QAQNQGLGQVHPPVLV--------APQAAISLPMLNQQQQHHQRMMQMQMR 1238

  Fly   262 TEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQ-------EDTIRLDIVNNPVE 319
            ..|..:.:.|..  |.|:.|   |::.:     |:.|..:.::|       ...||.|.:.:|:
 Worm  1239 GGPPGQFMMRAQ--PPQQPQ---INMHN-----HEIAKRMLMQQFRNAHPVMGGIRHDEITDPI- 1292

  Fly   320 STSIVITEEPKDLEKSTEELAFALPLASSTEV-----DLKSPPDLSSTALATSIKSPSSVSIDSA 379
                     .:|:....|.:.|.:...:..|.     ....||.:....:.
 Worm  1293 ---------MRDVYDCLEAIVFDVHTVAEREAMQAAGQQPPPPHIMQRMMQ-------------- 1334

  Fly   380 KGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVG-NMPSHPQRSSLDNANV-PIQ 442
                  ..||.|.                .|.::.|....|:.| .:|..|....|...:| |.:
 Worm  1335 ------QHPGGPG----------------GPRLIMPGQFPQLQGRRIPQQPPPVQLPQVDVDPPK 1377

  Fly   443 VHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHG-----PKSAKYRQM---------- 492
            ...:.....|.    ..:|..::.....:|...|::|::..     ||..|..::
 Worm  1378 TAAKRKKGGGN----PKKNASSYPAAGEYDAWIEQMRMRFRLCPDIPKKQKEPRLNRPGCEFVSH 1438

  Fly   493 ---------VPKRTKVV------------------------IWRQAIEEAQAMTQIPYSDRLEKF 524
                     ..|||.:|                        |..|.:...|...||    ||...
 Worm  1439 GLTDMAVRATKKRTPLVGEFGAMRVKRGTRLFGNEERGEKSIMFQDLNLYQVEPQI----RLFAL 1499

  Fly   525 YQ----TYENVV------------------TLNRQK---------RKRTKYMMQ----------- 547
            |.    |.|:.|                  .||:::         |.|.:||.:
 Worm  1500 YNNPLPTMEDDVFRDEEDQIIDKPTSALQKLLNKKRGASGAMDHIRSRARYMEETNIPPAPERGM 1564

  Fly   548 -----------------DTSDV--GSSLYDSTD---NLHNKQGTQLLAVKRERSES-PFSPAFSP 589
                             :|.|:  .||:.:..|   .|| :|...|||:|.|.:.| ..:|..||
 Worm  1565 FYENVEAEEEVTVELVFNTCDITEESSVDEKKDVCGRLH-EQIRDLLAIKDEVAWSMEDTPPESP 1628

  Fly   590 VKSKNEKRAKRRKLSNGTEADTGSNSMA----------------------------VTPSQTETT 626
            |....|..|     :.|....|.|.|.|                            |.|||::.:
 Worm  1629 VSRSPEPEA-----TVGAVQQTSSTSRAPSEATEREIKREVEEEAAPVAPEIKREIVEPSQSQNS 1688

  Fly   627 VD----SSAYENPEFRQLLSAVME--------YVMMNR------------------SDEKVEKVL 661
            ..    ..|.|:.....:::...|        .|:..|                  |:||.::.|
 Worm  1689 SQCKNCQKALESHSSTSIVTVKAEKLNLAPTGSVVTTRAAPVPPGVPGAPGAPIAPSEEKTKEEL 1753

  Fly   662 LSVVS-----NIWSLKQIQLRELERDLASGEIEEPLGSSV-----------VGRGSGVG---TIK 707
            .|..|     .:.|..:..|.|.|...|...:.|.:.:.:           |.:|....   |..
 Worm  1754 ASFCSKKCYYELASATRAPLTEEEVAAAEQHVSEEVYNKLKQVLTENIVKAVSQGKKPDPQLTSP 1818

  Fly   708 RLSNRLMTMMVRRSMTPVVTPS---TTPAPSE-PDRRLSEPPKTKKPVNRPIEEVIEDILQLDSK 768
            |.:..:|....|.::|.|...|   ...||.| |.:|.:|..:..|...:.|.:...:|.|..:.
 Worm  1819 RDTRCMMDEGRRENVTIVPVASLIGAVEAPKEAPSQRAAEAAEDWKAYTKSIWDSFVNIQQQHAH 1883

  Fly   769 YLFR---GLSREP------ICKYCYQAG-SDLVRCSRTCS----SWLHADC-------LERKVTG 812
            ::..   |:...|      ||.:|...| .:..||.|..|    .|:|.:|       .|.:..|
 Worm  1884 HILSPKIGVPHPPYHLDKRICVFCGGIGDGETTRCGRLISLTEFYWVHVNCALWSAEVFENQTGG 1948

  Fly   813 APMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPA 877
                                        ..:....|.......|..|.  .|...|.||::.
 Worm  1949 ----------------------------LTNVDRAVLRAAQTACDHCK--RPGASVKCHKMN--- 1980

  Fly   878 VPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSC---------------CKYWPQASSSKHSA 927
                                       ||..:|..|               ||...:.|:.....
 Worm  1981 ---------------------------CGVNYHVLCAMQNNGFFIKDRTFICKQHEKVSNQAIVG 2018

  Fly   928 RCP--RHVCHTCVSDDPSGKFQQL-----GSSKLAKCVRCPA-TYHQLSKCIPAGTQMLNTTNII 984
            |..  |.:   .|..|.:....:|     |.:   .|:|..| |::::....|...:..:|.:.|
 Worm  2019 RLDALRRI---YVKRDENTMLTRLFELTDGPT---LCMRLGAFTFYKIGSITPKQLKRFHTKDYI 2077

  Fly   985 CP-RHNIAKADAHVNVLW------------CYI---------CVKGGE--LVCCETC-------P 1018
            .| .:.|.:      :.|            |.|         .||..|  .:|.:..       |
 Worm  2078 FPNNYRITR------LFWSPKSHRERMMFECIIEDRNNQPIFVVKSLEDPTICYKAVSASKAWQP 2136

  Fly  1019 IAVHAH------------------CRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPA 1065
            |....|                  |.......||:.|.:..||  ||.: :.::...:..:..|.
 Worm  2137 IYEKVHQLREQQQGDSLKFFGSQICGETLFGLNENAITKITES--LPGF-DTIFTYQHRHQNSPV 2198

  Fly  1066 IILPPTEVPSNILKKAHGE--NDFVVRFF--------GTHDH-----GWISRRRVYLYIEGDTGD 1115
            :.||..|   |::..|..|  |..:.:.|        |||.|     |..|:..:..     :..
 Worm  2199 LELPLAE---NLMGCARAEPRNRTIGQHFRTKPQPMGGTHHHIGSASGLSSQATIIA-----SSS 2255

  Fly  1116 GHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKA----VPPLR 1176
            ....:|...|...|.|..|              :..|..|.:.:   |.:....:|    :||..
 Worm  2256 SSANESLQSRQAATSVTSA--------------NSGRTRGVRSY---YTEEAAARARAFGIPPEM 2303

  Fly  1177 FSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYM 1241
            .|.:|...:|.|.                :..|:    .|.|.....::|::..|.  |:
 Worm  2304 ASLSLRMETTQNA----------------QTAFS----AYQKMRREWKDRVYLARS--RI----- 2341

  Fly  1242 NERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGN 1306
              .|.||..:..|::|||:|||.||:| .:|.....|.:...::...|...::::::|||...|.
 Worm  2342 --AGLGLYAKVDISMGDFIIEYKGEII-RSEVCEVREIRYVAQNRGVYMFRIDEEWVIDATMAGG 2403

  Fly  1307 LARFMNHSCEPNCETQKWTVNCIHR---VGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAK 1368
            .||::||||:|||.||........|   :.|.|.:.|..|.|||::|.::......|..|.|||.
 Worm  2404 PARYINHSCDPNCSTQILDAGSGAREKKIIITANRPISANEELTYDYQFELEGTTDKIPCLCGAP 2468

  Fly  1369 RC 1370
            .|
 Worm  2469 NC 2470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	24/168 (14%)
		PHD2_NSD	867..932	CDD:277040	11/81 (14%)
		PHD3_NSD	933..988	CDD:277041	12/61 (20%)
		PHD4_NSD	1001..1041	CDD:277042	14/87 (16%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	20/109 (18%)
		AWS	1183..1233	CDD:197795	7/49 (14%)
		SET_NSD	1233..1375	CDD:380950	47/141 (33%)
set-16	NP_499819.3	PHD_SF	42..84	CDD:276966
		PHD4_KMT2C_like	427..477	CDD:276987
		PHD5_KMT2C_like	479..524	CDD:276988
		PHD6_KMT2C_like	554..604	CDD:276989
		HMG_KMT2C-like	936..1002	CDD:438813
		ePHD2_KMT2C_like	1904..2008	CDD:277136	25/163 (15%)
		FYRN	2053..2104	CDD:461787	9/56 (16%)
		FYRC	2112..2199	CDD:197781	16/89 (18%)
		SET_KMT2C_2D	2319..2474	CDD:380948	52/166 (31%)