DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD and met-1

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_491340.2 Gene:met-1 / 172026 WormBaseID:WBGene00016603 Length:1604 Species:Caenorhabditis elegans


Alignment Length:1061 Identity:209/1061 - (19%)
Similarity:343/1061 - (32%) Gaps:396/1061 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   539 RKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKL 603
            :|||: |:|......:::.|..            |||..:::.| :|   ...:|..||.:..|:
 Worm    10 KKRTE-MVQTRRKTAAAVQDGG------------AVKENKAKPP-AP---QTPTKRAKRGRPPKI 57

  Fly   604 SNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLL--SAVMEYVMMNRSDEKVEKVLLSVVS 666
            .  |:|:|.:     |||.:...||.         :||  |...:.::.|.:|..:||       
 Worm    58 K--TDANTLN-----TPSTSSNLVDD---------KLLIESESQDSILTNEADSFLEK------- 99

  Fly   667 NIWSLKQIQLRELE--RDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRL--------------MT 715
                    ::.|:|  .|:...:|..|...||:.:       :|.|.||              :.
 Worm   100 --------EVEEIEDSSDILPDKINSPEKPSVLVK-------RRSSTRLKVKTDEDEKDVPVNIE 149

  Fly   716 MMVRRSMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIE-------------DILQLDS 767
            :.|....:..:.|::...|.:|     :|..:..|:..|||:::|             :|...|.
 Worm   150 VAVLEEKSIQIEPTSPAHPEDP-----QPSTSSLPLVEPIEDIVEPNEPTSSADPPVSNIKDEDI 209

  Fly   768 KYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKS 832
            |      ..||:.|   :..||........:|....|....:.....:|..    ::.:|.|   
 Worm   210 K------EEEPLIK---KPASDESESMDIANSESGNDSDSSEADPRTIPSF----SIPLPDT--- 258

  Fly   833 PSPD-----EDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTP 892
            |.|:     |.||..|.|.....|.|                    :||    ..|..:.|:..|
 Worm   259 PPPNFAKRGEIHVDVDQKNSKQSGES--------------------QSP----WERAREKSASNP 299

  Fly   893 IEDKLLTCSQPMCGKRFHTSCCKYWPQASSS------------------------------KHSA 927
            :...  |.|:|    |.|.....|....:.|                              |.:|
 Worm   300 LSSP--TMSRP----RIHFLHPAYQSFTNDSVSPLPPPPPEPAPAREKVENGGPTTFKMTFKKAA 358

  Fly   928 RCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAK 992
            ..|  :..|...:.||.                |.....:|..|  ....:|::..|....:.||
 Worm   359 NIP--ILKTSAFEQPSS----------------PPPSSSVSSSI--SLSEVNSSTSIASESSPAK 403

  Fly   993 ADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKF 1057
            ..::.::                                         ..|..||....:...|.
 Worm   404 RSSNFDL-----------------------------------------TASNELPPPQMVELPKL 427

  Fly  1058 NNFRWWPAI--------------IL--------------------PPTEVPSN------------ 1076
            :.|...||:              ||                    ||.::..:            
 Worm   428 SFFNMPPAVRSAEDDSAMTSEEPILLLRSPNSATPDDDALFLTTPPPPKMTESEIQALKVATEKV 492

  Fly  1077 ---ILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTG-------- 1130
               |.::...|.|...|    .|.....|||       |..|....|:...||...|        
 Worm   493 NQVIARREDSEKDVRHR----EDRDDYDRRR-------DDRDRRSRKTDSERNDQRGRQREDDER 546

  Fly  1131 --------------------------------VEEASRFLPIIKARRQEQDMERQSGNK------ 1157
                                            .:|..|.......::|::|..:....|      
 Worm   547 RAREREREVTKRHDREREEMRLQKQKDEERRKKDEEERIQKENDEKKQKEDEAKMEEEKKKIKEE 611

  Fly  1158 -LHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAG---CLNRMLFNECNPEYCK 1218
             :..|.:..|..:|.:......:..|.| ||.|     |..|....   |:||.:..|| |..|:
 Worm   612 EMKIPEFELISESKYLTRNANKKKTESL-TCEC-----HRTGGNCSDNTCVNRAMLTEC-PSSCQ 669

  Fly  1219 AGSLCENRMFEQRKSPRLEVVYM-NERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQR 1282
            .  .|:|:.|.::|...:|..:. ..:|.||...:.|..|.|:|||:|||:...::::|..:...
 Worm   670 V--KCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAA 732

  Fly  1283 DRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTV----NCIHRVGIFAIKDIPVN 1343
            |:...:::|.....:.|||...||.:||:||||:||...:||:|    ..::|||.|:.:.|...
 Worm   733 DKKHKHHYLCDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAG 797

  Fly  1344 SELTFNYLWDDLMNNSKKA--CFCGAKRCSGEIGGKLK-------DDAVKAHAKLKQMRRAKASA 1399
            .|:||:|   ..:|..:.|  ||||:..|||.||.|.:       ||.|                
 Worm   798 EEITFDY---QFVNYGRDAQQCFCGSASCSGWIGQKPEEFSSDEDDDIV---------------- 843

  Fly  1400 VRIHVKPKKTPKVKHISADDE 1420
                       ..:||:.|:|
 Worm   844 -----------TTRHINMDEE 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898
PHD2_NSD 867..932 CDD:277040 15/94 (16%)
PHD3_NSD 933..988 CDD:277041 8/54 (15%)
PHD4_NSD 1001..1041 CDD:277042 0/39 (0%)
WHSC1_related 1047..1141 CDD:99899 25/182 (14%)
AWS 1183..1233 CDD:197795 16/52 (31%)
SET 1234..1354 CDD:214614 41/124 (33%)
met-1NP_491340.2 PHA03283 <219..308 CDD:223032 23/121 (19%)
AWS 637..682 CDD:197795 17/53 (32%)
SET 694..810 CDD:214614 41/118 (35%)
tolA_full <1300..>1375 CDD:274303
WW 1366..1393 CDD:238122
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 109 1.000 Domainoid score I3988
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.940

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