Protein Alignment NSD and ash1

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_061503996.1
• Gene: ash1 / 1281642
• VectorBaseID: AGAMI1_008353
• Length: 3636
• Species: Anopheles gambiae
• Alignment Length: 1476
• Identity: 317/1476 - (21%)
• Similarity: 480/1476 - (32%)
• Gaps: 508/1476 - (34%)

  Fly    23 NSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAAEESELE 87
            :|.|.|..:.:..|.|......|..::...|:  :.|||..   :|..........|||......
Mosquito  1812 SSISSSTVSRERQATGASGQPGTTSENSAGPQ--HRSTPPA---RPSVIQSSGSVHPAASSGAYS 1871

  Fly    88 SQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSD--DTIRTTRRRVNQ 150
            :....|.....:..|          :|:..:.|.      ::.|:.::..:  |:.|...:.|..
Mosquito  1872 ASSAGPPPGVFEPTV----------DLELVIPPP------SSIPSLIAKVEMLDSPRLGGKDVAA 1920

  Fly   151 AA-ALNNSSAG-----------ETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIK 203
            || |:.:||:|           |.|....|:.|...|.|.|....:.....|.:....:||||.|
Mosquito  1921 AAGAIGSSSSGSSGNVATKLESEELQVLTAAQRKAAGLGAGSALLATISTASASSEKVLEKLLTK 1985

  Fly   204 NGA---------SSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKS 259
            .||         ..||.|||..              ||:|.|::|
Mosquito  1986 TGAHHLLMKKKRKKPNRTGFPT--------------VKKKKKKLP-------------------- 2016

  Fly   260 VKTEPIDEEVDRTDEAP----------------TQEAQTTAISIKSETEAEHKAAVDVHIKQEDT 308
             ..:|:|:.:...|..|                ..||:.|.:   .|.:.:|..:...|
Mosquito  2017 -DNDPLDDGLSVLDLKPEVGPDLFDSSNLTRHVPSEAEKTRM---KERQQQHHPSTGKH------ 2071

  Fly   309 IRLDIVNNPVESTSIVITE-----EPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSI 368
            ...|.|....|.|...|..     .|:....|.|:|...|||......|:.:.|..:......|:
Mosquito  2072 AACDRVPKEGEPTDCFIERHTGVGRPRLSVVSLEKLQGKLPLPGGGSRDVATTPPATGGRGRKSV 2136

  Fly   369 KSP----SSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHP 429
            .:|    ..::...::||.  .:|                          |......||......
Mosquito  2137 INPLAAEHQLAAQRSRGLR--DEP--------------------------PAAAAGTVGRKGKKR 2173

  Fly   430 QRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVP 494
            |     .|..|:                 ||   |..|.:....|..|:|      |||.|
Mosquito  2174 Q-----EAPKPL-----------------PE---TAVGKRQKASMDTEIR------SAKER---- 2203

  Fly   495 KRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDS 559
            .|:|.|        :.|..|:|             |:|.|:            :|...|::..::
Mosquito  2204 NRSKSV--------SVASEQLP-------------NIVRLS------------ETLSKGAAAKEN 2235

  Fly   560 TDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTP---- 620
            .:|.....|....|.||...|    ||.|...:..:..|       |....|.|:|:|:.|
Mosquito  2236 KENSRLPPGRPPSAAKRAGKE----PATSAETAPQDDAA-------GVIRRTRSSSVALDPSEVK 2289

  Fly   621 -------------------SQTETTV-----DSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVL 661
                               ||:.|.|     ..:|..|.:...|.|..:...:.:||..:::.|:
Mosquito  2290 KLHHHHHHDAEHESAGKGASQSSTPVRPHSGGIAALHNEDSTSLDSMPLLKRLHSRSISRMQSVI 2354

  Fly   662 LS--VVSNIWSLKQIQLRELERDLASGEI------EEPLGSSVVGRGSGVGTIKRLSNRLMTMMV 718
            ..  |:..|.:..:...|...|...:..|      ..|..::..|||.....:....|.....|.
Mosquito  2355 TPTVVIEPIATSPKTPGRPRGRPRTTSPITATETPNSPTATAGPGRGRPRTALALTGNPSAASMQ 2419

  Fly   719 RRSMTPVVTPSTTPAPSEP---------DRRLSEPPKTKKPVNR-----------------PIEE 757
            |...:|:.:||.|.|.:|.         |.|.|.||...:|:..                 |:..
Mosquito  2420 RTPASPLSSPSPTVAAAERTAGRKKQRLDGRKSVPPGLAEPIESARLATRVTASKSVTPTPPVGT 2484

  Fly   758 VIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRK 822
            ||...|:       ||.|.|.                      |.|..|| |.|..|      ||
Mosquito  2485 VIPTRLK-------RGKSDET----------------------LRAQQLE-KPTKKP------RK 2513

  Fly   823 ALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDS 887
            .|   |.|..|||:   ..|...:..|:.:.:|       ||........|..|| .||...|
Mosquito  2514 EL---PGSAEPSPE---TAAHLSKRSAIASPIV-------EPVDPEETAHVLQPA-SSTEELE-- 2562

  Fly   888 SSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDP----SGKFQQ 948
              |.|:                        |.........|         ::|.|    ||:.::
Mosquito  2563 --HDPL------------------------PPDEGPSDFLR---------LTDTPSPTSSGETRE 2592

  Fly   949 LGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVK-----G 1008
            |.....|...|...|..:|                  ||.....|....:      |.|     |
Mosquito  2593 LAMGGAAAGGRGAGTSKKL------------------PRKKYITAGLFSD------CYKDDGTTG 2633

  Fly  1009 GELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEV 1073
            ||              .|:.|               :.|                |..:|||...
Mosquito  2634 GE--------------GRSGP---------------KTP----------------PETLLPPPAY 2653

  Fly  1074 PSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFL 1138
            ....|::.  ..||.:    .:|..|:..       .|.....:...|..:|...|.|
Mosquito  2654 CERFLRRT--VRDFQL----PYDLWWLQE-------NGKLPGRNSVPSWNYRKIRTNV------- 2698

  Fly  1139 PIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGC 1203
                                    |..:|.|.:.         ::.:.|||.|    ..|.:..|
Mosquito  2699 ------------------------YYDVKANPST---------DNNTQCNCKP----DSGCQDDC 2726

  Fly  1204 LNRMLFNECNPEYCKAGSLCENRMFEQRK-SPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEV 1267
            ||||::.||.||.|..|..|.|...::.: :|.||.....|:|:|:.:||.|:.|.|::||:|||
Mosquito  2727 LNRMVYTECVPEQCPCGDRCRNTCIQRHEYAPGLERFMTEEKGWGIRSRERISKGTFIMEYLGEV 2791

  Fly  1268 INHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRV 1332
            :...||:.||.....: |.::|.|.::...:||....|:..||:||||.||||.|||:||.:.|:
Mosquito  2792 VTEREFKERMRTMYLN-DTHHYCLNLDGGLVIDGHRMGSDCRFVNHSCAPNCEMQKWSVNGLFRM 2855

  Fly  1333 GIFAIKDIPVNSELTFNYLWDDLMNNSK-KACFCGAKRCSGEIGGK 1377
            .:||::|||.|.||.::|.: .|.|.|: :.|.||:::|.|.||||
Mosquito  2856 ALFAMRDIPPNEELCYDYNF-SLFNPSEGQPCRCGSEQCRGVIGGK 2900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	21/118 (18%)
		PHD2_NSD	867..932	CDD:277040	10/64 (16%)
		PHD3_NSD	933..988	CDD:277041	10/58 (17%)
		PHD4_NSD	1001..1041	CDD:277042	7/44 (16%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	14/94 (15%)
		AWS	1183..1233	CDD:197795	18/50 (36%)
		SET_NSD	1233..1375	CDD:380950	59/142 (42%)
ash1	XP_061503996.1	None