Protein Alignment NSD and LOC1270733

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_061511031.1
• Gene: LOC1270733 / 1270733
• VectorBaseID: AGAMI1_003298
• Length: 6762
• Species: Anopheles gambiae
• Alignment Length: 1824
• Identity: 334/1824 - (18%)
• Similarity: 568/1824 - (31%)
• Gaps: 637/1824 - (34%)

  Fly     2 KLSTDAHSEIEGD----AAHGNVLCNSASDSLTATDEVAAGND------ESVATEGD-------- 48
            :||.::.:.::.:    |:....:.:|.:.:.::|...|.||.      .:.||.|.
Mosquito  5116 RLSLESTNVVKSEPVDSASDDASVSSSTAQAASSTSATAGGNQPKPDTPAAAATAGSGCKFSTMP 5180

  Fly    49 ---DVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAAEE--------------------SELESQR 90
               .|....|:.|....:||...|.:...:.:.||...                    |.||:|.
Mosquito  5181 SSGTVAKSEDSQNVLLKQLLQNSGSSSASSVSSPAPSPIGRAVPSLITSQRAPSLGVVSSLEAQL 5245

  Fly    91 QTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPL------SDSDDTIRTTRRRVN 149
            ..||                   :..:.:|..|... ::.|.|.      |.|..|:.|......
Mosquito  5246 ARPV-------------------IPPSANPPAIQLI-SSQPIPAIAASISSISSSTVSTAAAAST 5290

  Fly   150 QAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIK--NGASSPNST 212
            .:|||.:.|:|.::.....:..............|:....:||.:...|...:.  :|.||.:.|
Mosquito  5291 PSAALMSVSSGTSIGSSTTTTSVTTASASNSTSSSSTAEAAKTKLISRETSFVSKPSGISSSHPT 5355

  Fly   213 GFEAGSEDLGIRPIVRKHVKRKMKRVPKAKV------------------TLELDE----KNQQEV 255
                  .:|....:.....|.:|.:...|..                  |::||.    ..|.:.
Mosquito  5356 ------PNLAANMLAASMKKEEMLQAAAAAAATTITTTTTTSGATVGQGTVKLDSGTITVTQLQA 5414

  Fly   256 DEKSVKTEPIDEEVDRTDEA-----PTQEAQTTAI-------SIKSETEAEHKAAV------DVH 302
            .:.:|.|....:::..|..|     |.|:.|..::       .::|:|.......|      :|.
Mosquito  5415 SQPTVTTAAASQQLQTTVTAAKSAMPPQQQQVNSLQFTQQNNQLQSKTLPNAATVVGSVGETNVT 5479

  Fly   303 IKQEDTIRLDIVNNPV----ESTSIVITEEPKDLEKSTEELA----------------------- 340
            |.:.|.:....|::..    .|||:.:|.:....|:|.:..|
Mosquito  5480 IVKRDPVTQQTVSSVTTVLPASTSVTVTAKSGPPEESMKRFAPSPVQQQIGDTTIVRTPTPTPSP 5544

  Fly   341 ----------FALPLASSTEVDLKSPPDLS----STALATSIKSPSSVSIDSAKGLSIVTDPGWP 391
                      .|.| .|.|.||:|..|:.|    |.::|::..:.|:||..:...:|....|..|
Mosquito  5545 GPMQQPSRPPSAAP-RSETPVDIKKEPEQSLNSGSASVASATTTTSTVSGTTTPIMSSPVAPMGP 5608

  Fly   392 TYQVGDLFWGKVFSYCFWPCMVCPDPLG------QIVGNMPSHPQRSSLDNANVPIQVHVRFFAD 450
            .....                |.|.|..      .:...:|.....|:......|....|.  |.
Mosquito  5609 PATTA----------------VTPSPAAAQTTPTALKSPLPPGSVESTTTITGSPAITKVE--AS 5655

  Fly   451 NGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSA----------KYRQMVPKRTKVVIWRQA 505
            :|..:.:  ..:.|...:|  ::..|.|..:...|.|          |.|:....|.::.|  |:
Mosquito  5656 SGGPSPV--STVPTATAIK--EEPTEPLTAEQAAKRAAELALELKKKKRREYQKNRRQMQI--QS 5714

  Fly   506 IEE---AQAMTQIPYSDRLEKFYQT-YENVVTLNRQKRKR------------------TKYMMQD 548
            .::   :||..:...|.::|:.|.| .:|::...||..:.                  |..:.:.
Mosquito  5715 NKDNAHSQAKKKPKKSVKIEEDYDTCIDNLMGQLRQLPQMQILEPQLPRNYGVCSVFGTGDLSKF 5779

  Fly   549 TSDVGSSLYDSTDNLHNKQG-TQLLAVKRERSESPF---------SPA----------FSPVKSK 593
            |:..|.|:  :|.:|..:.| .|:.::....:..||         :|.          |:|:|.:
Mosquito  5780 TNLKGYSI--ATGDLTGRYGDAQIPSIADFYNTKPFGVKDPPPEPTPVSVHRGFYDQEFAPIKFE 5842

  Fly   594 NEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLS--AVMEYVMMNRSDEK 656
            .|.|.:...:   .:.|..|....::.|..|.....|....|..|.:..  |..|...:.|....
Mosquito  5843 TEDRQRYEFV---RDRDLDSPDTIISTSSPECLRWDSPVSFPGLRLIKEEPAEDEQTAVYRQMSP 5904

  Fly   657 VEKVLLSVVSNIWSLKQIQLRE---LERDLASGEIEEPLGSSVVGRG---------SGVGT---- 705
            |..:|..:        .|:||:   |..| ::|..::  |::|.|..         :||.:
Mosquito  5905 VIPILAPI--------PIRLRKGITLSAD-SAGRPQQ--GANVAGSNKENEGFRETAGVKSRFGP 5958

  Fly   706 ---IKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPD------RRLSE-----PPKTKKPVNRPIE 756
               :|..||              ||.:.|...|..|      |.|:.     ||.|.:.|.|.:.
Mosquito  5959 PTPLKDTSN--------------VTVTLTLTSSAVDDIFGVLRDLANMLEIPPPTTYQIVERTVS 6009

  Fly   757 EVIEDI-------------LQLDSKYLFRGLSREPICKYC------------------------- 783
            ...:.:             ..:|.:.:..|.:|  .|::|
Mosquito  6010 PTSQKLGLYRTKGRDGKEGAPIDIQTILNGSAR--FCRHCDVVILSNIIIANASEFPLLAANGDV 6072

  Fly   784 -----------YQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDE 837
                       |..|....|..|.|                              |||   ..||
Mosquito  6073 GGQAELESEELYFCGEQCYRQFRCC------------------------------PTS---ILDE 6104

  Fly   838 --DHVTADAKEVVAVGTSLVCHECNVGEP-------EGCV-----ICHQVESPAV---------- 878
              |.....|......||:.:.|:.:.|.|       .|.|     :...||...|
Mosquito  6105 AGDSSAGAAALATGEGTAGLSHKPDTGVPNVDVAAVSGAVEIKQEVLEDVEMEDVTAGNSSTGSV 6169

  Fly   879 ---PSTPRKEDSSSHTPIEDKLLTCSQP---MCGKRF--HTSCC--------------------- 914
               |.:..::.......:|..:|..:.|   |.|.|:  :|..|
Mosquito  6170 KDAPGSGERKKKHPDDGVEVDVLAGAPPTKQMKGVRYKVYTPNCFGVQRFKKPSEKEITETLFRM 6234

  Fly   915 --KYWPQASSSKHSARCPRHVCHTC---VSDDPS--------------------GKFQ------- 947
              ...|.......:.||  ..|||.   |:|.||                    |.::
Mosquito  6235 SITVAPTPKMPDDTRRC--IFCHTVGDGVADGPSRLLNYDVDKWVHLNCALWSDGVYETVNGALM 6297

  Fly   948 ----QLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICV-- 1006
                .|..|..:.|..| :|.....||..  |:..|..::.|     |..|:         ||
Mosquito  6298 NLENALQQSLTSVCAFC-STLGATVKCFK--TRCANVYHLSC-----AMKDS---------CVFY 6345

  Fly  1007 KGGELVC----------CETCPIAVHAHCRNIPIKTNES----YICEECESGRLPLYGEIVWAKF 1057
            |....:|          .|...::|.   |.:.:..:||    .:....||..|...|.:::...
Mosquito  6346 KNKTTMCQTHAPKTEKDSELTTLSVQ---RRVYVDRDESRQVASVMHHSESNNLLRVGSLIFLNV 6407

  Fly  1058 NNFRWWPAIILPPTEVPSNILKKAHGENDF------VVRFFGTHDHGWISRR-----RVYLYIEG 1111
            ..       :||      :.|:..|..|..      ::||:      |..||     |....|..
Mosquito  6408 GQ-------LLP------HQLQSFHTPNYIYPIGYKIIRFY------WSMRRPNKRCRYICSIAD 6453

  Fly  1112 DTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNK-------LHP--------- 1160
            ..|...      ||              ::.....|:|:|.:....       |.|
Mosquito  6454 VCGRPE------FR--------------VLVQETAEEDIELRDATPKAVWQRILEPMAQLRKSCQ 6498

  Fly  1161 -----PPYVKIK-----TNKAVPPLRFSQNLEDLSTCNC------------LPVDEHPCG---PE 1200
                 |.|:..:     |..||  :|..::|..:.|...            ||:..:|.|   .|
Mosquito  6499 IVQLFPKYISGEDLFGLTEPAV--VRILESLPGIETLTDYRFKYGRNPLLELPLAINPSGAARTE 6561

  Fly  1201 AGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVV--YMNE-------------------- 1243
            ....:.:.:.:  |...:.||:.:...|....||..||.  |..:
Mosquito  6562 PKLKHTLSWKK--PHTQRTGSVSQRPTFVPTSSPAGEVACPYSKQFVHSKSSQYKKMKQEWRNNV 6624

  Fly  1244 -------RGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDA 1301
                   :|.||.....:.....||||:|||| ..|.....|::...|:...|...::::.::||
Mosquito  6625 FLARSKIQGLGLYAARDLEKHTMVIEYIGEVI-RTEVSELREKQYEARNRGIYMFRLDEERVVDA 6688

  Fly  1302 GPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCG 1366
            ...|.|||::||||.|||.|:...|:...|:.|||.:.|....||:::|.:|...:..|.:|.||
Mosquito  6689 TLSGGLARYINHSCNPNCVTEIVEVDRELRIIIFAKRRINRGEELSYDYKFDIEDDAHKISCMCG 6753

  Fly  1367 AKRC 1370
            |..|
Mosquito  6754 APNC 6757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	22/137 (16%)
		PHD2_NSD	867..932	CDD:277040	16/110 (15%)
		PHD3_NSD	933..988	CDD:277041	18/88 (20%)
		PHD4_NSD	1001..1041	CDD:277042	9/55 (16%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	16/105 (15%)
		AWS	1183..1233	CDD:197795	10/64 (16%)
		SET_NSD	1233..1375	CDD:380950	50/167 (30%)
LOC1270733	XP_061511031.1	None