DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSD and ash1l

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_031747239.1 Gene:ash1l / 108645568 -ID:- Length:2656 Species:Xenopus tropicalis


Alignment Length:1799 Identity:343/1799 - (19%)
Similarity:572/1799 - (31%) Gaps:708/1799 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 KPGQNPVQN------GAQPA---AEESELESQRQTPVQK--QQQQRVSMVNRKRDLIN------- 113
            |.||.|.|.      |..|.   ..:..:.|....|..|  :..:..|.:...|||.:       
 Frog   514 KLGQLPEQESLARGIGRAPLLAHTSKGSIPSASHKPTHKLYESHRTYSSLCASRDLFHKSKKCRS 578

  Fly   114 -------------LQSALSP-KYIGYANANSPTP-------------LSDSDDTIRTTRRRVNQ- 150
                         ||  :|| |.|...:...|.|             :|.|.......|.|..: 
 Frog   579 QDMPHLDVPPKWALQ--ISPSKLISSQSKEEPGPPILQPEVEIPPAQVSQSGQLFPKKRGRPRRQ 641

  Fly   151 -AAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNS--T 212
             |..:.....|.:|| .|.|......|.|.|.:           |.|..:...:.....|.|  .
 Frog   642 LAPPVLKPPCGLSLA-PNESIGVEASGAGCGAN-----------MDPFGEEPHRASDQCPESGRK 694

  Fly   213 GFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPT 277
            ....|:..| ::.|:||  ..|||.:.:.|:..::          .|..|||..:...|...:.:
 Frog   695 ALNRGNGQL-VKTIIRK--INKMKTIKRRKLVSQI----------LSGGTEPSAQVQPRLQGSVS 746

  Fly   278 QEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFA 342
            ..|.|.:..:..:.....|..:.:..::....::..::..:...|   |..|..||      :..
 Frog   747 SLAATFSSKLGQQINVSKKGTIYIGKRRGRKPKVAPLDCLLAKNS---TCPPSLLE------SLG 802

  Fly   343 LPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKG-LSIVTDPGWPTYQVGDLFWGKVFSY 406
            .|||:||     ..|  |:.:.|..:.||||..:.:..| ||.|:...                 
 Frog   803 QPLAAST-----IQP--SAASCAEVLPSPSSCHLSATSGALSPVSSDA----------------- 843

  Fly   407 CFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAF 471
                ..|.|..|..:  :|.|....|:|..      :.:|..|.:||:  :.|..||..:.    
 Frog   844 ----SFVEPSSLSYL--HMHSARHNSALQT------LAMRKAAKDGRQ--LSPPTLLPNSP---- 890

  Fly   472 DDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIP-----------YSDRLEKFY 525
                     .|..:.:..::..|         ..|.|:.:...||           .|||.||  
 Frog   891 ---------AHISELSSLKEATP---------SPISESHSDETIPSDSGIGTDNNSTSDRAEK-- 935

  Fly   526 QTYENVVTLNRQKRKRTKY-----MMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSP 585
                    |..|||:|..:     |..:.|.:.|||.:...:....:|...|:..          
 Frog   936 --------LCGQKRRRHSFEHMPLMPVEPSVLLSSLKEKHKHKCKHRGHDFLSYD---------- 982

  Fly   586 AFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEF----RQLLSAVME 646
                 |.|.:||.:::|..                       ....:::|:|    .:|:..:.:
 Frog   983 -----KIKRQKRKRKKKYP-----------------------QLRVHQDPDFLAELEELIGRLSD 1019

  Fly   647 YVMMNRSDEKVEKVLLSVV-----SNIWS----------------LKQIQLRELERDLASGEI-- 688
            ..:.:|:...:.:.||..:     :|.:|                ||:.:.|..:.....||:  
 Frog  1020 VRITHRTHHFIPRDLLPTIFRLNFNNFYSHPTFPLEPLHYIRKPNLKKKRGRPPKLRETIGEMPF 1084

  Fly   689 ---------------------------EEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVV 726
                                       ..|:|.|..||                          .
 Frog  1085 MHSLGFPLSGTGFYPSYGMPYSPSPLTPPPIGLSYYGR--------------------------Y 1123

  Fly   727 TPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLV 791
            .|:..|.|..|......||.:                                  |.:.||..|:
 Frog  1124 PPTIYPPPPSPSFTTPLPPPS----------------------------------YMHHAGHLLL 1154

  Fly   792 RCSRTCSSWLHA---DCLERKV---TG-APMPKIGSRKALVIPPT-----------------SKS 832
            ..::     .|.   ..|.::.   || ||:..:|:..:  :||.                 .:.
 Frog  1155 NPAK-----YHKKKHKLLRQEAFLGTGRAPLLSMGTYPS--VPPEMAYSWMFEHKHRHRHKHREH 1212

  Fly   833 PSPDEDHVTADAKEVVAVGTSLV---------------------CHECNVGEPEGCVICHQVESP 876
            ..||:..::.|....|:...|::                     .|.|::..|      |...|.
 Frog  1213 RLPDQAQLSIDPLTGVSSSRSVLESLKRYRFGKDSASDRYKHKDKHRCHLACP------HLSPSQ 1271

  Fly   877 AVPSTPR---KEDSSS--------HTPIEDKLLTCSQPMCGKRFHTSCCKYWP---QASSSKHSA 927
            .:.|...   :.||..        |:|::   :.||....|:    |...:.|   ||||.:|:.
 Frog  1272 GLLSRDEHWARRDSPETHSLSLGLHSPLQ---IDCSDSSPGR----SIGGFTPSSEQASSDEHTN 1329

  Fly   928 RCPRHVCHTCVSDDPSGKF----------------------QQLGSSKLAKCVRCP----ATYHQ 966
            .....:.:...|...||..                      ::..|.:||:.:..|    .....
 Frog  1330 LFTSAIGNCRPSGSVSGPVGRKALNENSPFFMDSTLSRSLRKEPPSDRLAQALSVPQERSLRQSD 1394

  Fly   967 LSKCIPA-------------------GTQMLN---------TTNIICPRHNIAKADA---HVNVL 1000
            .|.|.|:                   ||:|.:         ...|:   || .|.|.   .|.| 
 Frog  1395 RSSCSPSRRRTPSESPSPALMGVGARGTRMGSLGDDSAEPFVQRIV---HN-EKPDTLEKSVGV- 1454

  Fly  1001 WCYICVKGGELVCCETCPI--------AVHAHCR------NIPIKTNESY----------ICEEC 1041
                           .|||        :...|.|      ..|..:.|||          :...|
 Frog  1455 ---------------QCPIGSVPASGGSSRGHSRERSQENRNPTASIESYNGPGPASSRQVGSGC 1504

  Fly  1042 ES---------------GRLPLYGEIVWAK---------------------FNNF--------RW 1062
            .|               .|:..|..|:.:|                     .|||        |.
 Frog  1505 SSQQLKRSMVEAIHKRARRMYSYDRILASKKNLDHVNKILKAKKLQRQSRTGNNFVKRRPGRPRK 1569

  Fly  1063 WP------AIILP--PTEVPSNILKKAHGENDFVVRFFGTHDH---GW----------ISRRRVY 1106
            :|      |.:.|  .::..::::       :.||:.....|.   ||          :.:|...
 Frog  1570 YPVDSLQAAQLFPIMRSDTVTDVI-------EAVVQSVSLRDEQHKGWKRKHLELDKQVKKRPKS 1627

  Fly  1107 LY-----------------------IEGD-----TGDGHKT--------------------KSQL 1123
            ||                       |.|:     .||...|                    |:.|
 Frog  1628 LYEDDQESNISLSECAIVEAPAAPDISGNPEVERAGDLLHTMAPPPQKQKKAPRPPKKKYQKAGL 1692

  Fly  1124 FRNYTTGVEEASRFLPIIKARRQEQDMERQSG-------------------------------NK 1157
            |.:....::..||.:.:.|.:.:....|.:.|                               |:
 Frog  1693 FSDMYKTLDPKSRLVQLKKEKLEYDPREHEYGLLPAPIHIGKYLRQKRNDFQLPYDILWQWKHNQ 1757

  Fly  1158 LHPPP----YVKIKTN--KAVPPLRFSQNLEDLSTCNC-LPVDEHPCGPEAGCLNRMLFNECNPE 1215
            |:..|    |.||::|  ..|.||    :..:.:.||| .|.::...|....|||||:|.||:|.
 Frog  1758 LYKKPDVPLYKKIRSNVYVDVKPL----SGYEATMCNCKCPDNQSEKGCVEDCLNRMIFAECSPN 1818

  Fly  1216 YCKAGSLCENRMFEQRKSPR-LEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRR-ME 1278
            .|..|..|.|:..::.:..: ||......:|:|:..:||:....|:|||:|||::..||:.| :|
 Frog  1819 TCPCGEQCNNQCIQRHEWVQCLERFRAEGKGWGIRTKEPLKASQFIIEYLGEVVSETEFRNRTIE 1883

  Fly  1279 QKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVN 1343
            |.....|  :|.|.::...:||:...||.|||:||||:||||.|||:||.::|:|::|:||:|..
 Frog  1884 QYHNHSD--HYCLSLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAG 1946

  Fly  1344 SELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK---------DDAVKAHAKL---KQMRRAK 1396
            :|||::|.:.......::.|.||.::|.|.||||.:         ...|.:..:|   |:.|::|
 Frog  1947 TELTYDYNFHSFNTEKQQVCKCGVEKCRGIIGGKSQRVNGLANKGGHLVPSQRRLGRSKEKRKSK 2011

  Fly  1397 --------------ASAV--------RIHVKPKKTPK----VKH 1414
                          :.|:        ::|:||....:    :||
 Frog  2012 HRLKKRKGHFPEDRSDAIGTPSRLGPQLHMKPMSNRERNFVLKH 2055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 17/116 (15%)
PHD2_NSD 867..932 CDD:277040 17/78 (22%)
PHD3_NSD 933..988 CDD:277041 14/108 (13%)
PHD4_NSD 1001..1041 CDD:277042 9/63 (14%)
WHSC1_related 1047..1141 CDD:99899 28/191 (15%)
AWS 1183..1233 CDD:197795 18/50 (36%)
SET 1234..1354 CDD:214614 51/121 (42%)
ash1lXP_031747239.1 PHA03307 25..>408 CDD:223039
AWS 1785..1836 CDD:197795 18/50 (36%)
SET_ASH1L 1839..1979 CDD:380951 57/141 (40%)
Bromo_ASH1 2132..2237 CDD:99955
PHD_ASH1L 2275..2317 CDD:277023
BAH_polybromo 2354..2488 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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