Protein Alignment NSD and ash1l

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_031747239.1
• Gene: ash1l / 108645568
• XenbaseID: XB-GENE-6035627
• Length: 2656
• Species: Xenopus tropicalis
• Alignment Length: 1799
• Identity: 344/1799 - (19%)
• Similarity: 574/1799 - (31%)
• Gaps: 708/1799 - (39%)

  Fly    67 KPGQNPVQN------GAQPA---AEESELESQRQTPVQK--QQQQRVSMVNRKRDLIN------- 113
            |.||.|.|.      |..|.   ..:..:.|....|..|  :..:..|.:...|||.:
 Frog   514 KLGQLPEQESLARGIGRAPLLAHTSKGSIPSASHKPTHKLYESHRTYSSLCASRDLFHKSKKCRS 578

  Fly   114 -------------LQSALSP-KYIGYANANSPTP-------------LSDSDDTIRTTRRRVNQ- 150
                         ||  :|| |.|...:...|.|             :|.|.......|.|..:
 Frog   579 QDMPHLDVPPKWALQ--ISPSKLISSQSKEEPGPPILQPEVEIPPAQVSQSGQLFPKKRGRPRRQ 641

  Fly   151 -AAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGF 214
             |..:.....|.:|| .|.|......|.|.|.:           |.|..:...:.....|.| |.
 Frog   642 LAPPVLKPPCGLSLA-PNESIGVEASGAGCGAN-----------MDPFGEEPHRASDQCPES-GR 693

  Fly   215 EAGSEDLG--IRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPT 277
            :|.:...|  ::.|:||  ..|||.:.:.|:..::          .|..|||..:...|...:.:
 Frog   694 KALNRGNGQLVKTIIRK--INKMKTIKRRKLVSQI----------LSGGTEPSAQVQPRLQGSVS 746

  Fly   278 QEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFA 342
            ..|.|.:..:..:.....|..:.:..::....::..::..:...|   |..|..||      :..
 Frog   747 SLAATFSSKLGQQINVSKKGTIYIGKRRGRKPKVAPLDCLLAKNS---TCPPSLLE------SLG 802

  Fly   343 LPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKG-LSIVTDPGWPTYQVGDLFWGKVFSY 406
            .|||:||     ..|  |:.:.|..:.||||..:.:..| ||.|:...
 Frog   803 QPLAAST-----IQP--SAASCAEVLPSPSSCHLSATSGALSPVSSDA----------------- 843

  Fly   407 CFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAF 471
                ..|.|..|..:  :|.|....|:|..      :.:|..|.:||:  :.|..||..:.
 Frog   844 ----SFVEPSSLSYL--HMHSARHNSALQT------LAMRKAAKDGRQ--LSPPTLLPNSP---- 890

  Fly   472 DDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIP-----------YSDRLEKFY 525
                     .|..:.:..::..|         ..|.|:.:...||           .|||.||
 Frog   891 ---------AHISELSSLKEATP---------SPISESHSDETIPSDSGIGTDNNSTSDRAEK-- 935

  Fly   526 QTYENVVTLNRQKRKRTKY-----MMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSP 585
                    |..|||:|..:     |..:.|.:.|||.:...:....:|...|:..
 Frog   936 --------LCGQKRRRHSFEHMPLMPVEPSVLLSSLKEKHKHKCKHRGHDFLSYD---------- 982

  Fly   586 AFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEF----RQLLSAVME 646
                 |.|.:||.:::|..                       ....:::|:|    .:|:..:.:
 Frog   983 -----KIKRQKRKRKKKYP-----------------------QLRVHQDPDFLAELEELIGRLSD 1019

  Fly   647 YVMMNRSDEKVEKVLLSVV-----SNIWS----------------LKQIQLRELERDLASGEI-- 688
            ..:.:|:...:.:.||..:     :|.:|                ||:.:.|..:.....||:
 Frog  1020 VRITHRTHHFIPRDLLPTIFRLNFNNFYSHPTFPLEPLHYIRKPNLKKKRGRPPKLRETIGEMPF 1084

  Fly   689 ---------------------------EEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVV 726
                                       ..|:|.|..||                          .
 Frog  1085 MHSLGFPLSGTGFYPSYGMPYSPSPLTPPPIGLSYYGR--------------------------Y 1123

  Fly   727 TPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLV 791
            .|:..|.|..|......||.:                                  |.:.||..|:
 Frog  1124 PPTIYPPPPSPSFTTPLPPPS----------------------------------YMHHAGHLLL 1154

  Fly   792 RCSRTCSSWLHA---DCLERKV---TG-APMPKIGSRKALVIPPT-----------------SKS 832
            ..::     .|.   ..|.::.   || ||:..:|:..:  :||.                 .:.
 Frog  1155 NPAK-----YHKKKHKLLRQEAFLGTGRAPLLSMGTYPS--VPPEMAYSWMFEHKHRHRHKHREH 1212

  Fly   833 PSPDEDHVTADAKEVVAVGTSLV---------------------CHECNVGEPEGCVICHQVESP 876
            ..||:..::.|....|:...|::                     .|.|::..|      |...|.
 Frog  1213 RLPDQAQLSIDPLTGVSSSRSVLESLKRYRFGKDSASDRYKHKDKHRCHLACP------HLSPSQ 1271

  Fly   877 AVPSTPR---KEDSSS--------HTPIEDKLLTCSQPMCGKRFHTSCCKYWP---QASSSKHSA 927
            .:.|...   :.||..        |:|::   :.||....|:    |...:.|   ||||.:|:.
 Frog  1272 GLLSRDEHWARRDSPETHSLSLGLHSPLQ---IDCSDSSPGR----SIGGFTPSSEQASSDEHTN 1329

  Fly   928 RCPRHVCHTCVSDDPSGKF----------------------QQLGSSKLAKCVRCP----ATYHQ 966
            .....:.:...|...||..                      ::..|.:||:.:..|    .....
 Frog  1330 LFTSAIGNCRPSGSVSGPVGRKALNENSPFFMDSTLSRSLRKEPPSDRLAQALSVPQERSLRQSD 1394

  Fly   967 LSKCIPA-------------------GTQMLN---------TTNIICPRHNIAKADA---HVNVL 1000
            .|.|.|:                   ||:|.:         ...|:   || .|.|.   .|.|
 Frog  1395 RSSCSPSRRRTPSESPSPALMGVGARGTRMGSLGDDSAEPFVQRIV---HN-EKPDTLEKSVGV- 1454

  Fly  1001 WCYICVKGGELVCCETCPI--------AVHAHCR------NIPIKTNESY----------ICEEC 1041
                           .|||        :...|.|      ..|..:.|||          :...|
 Frog  1455 ---------------QCPIGSVPASGGSSRGHSRERSQENRNPTASIESYNGPGPASSRQVGSGC 1504

  Fly  1042 ES---------------GRLPLYGEIVWAK---------------------FNNF--------RW 1062
            .|               .|:..|..|:.:|                     .|||        |.
 Frog  1505 SSQQLKRSMVEAIHKRARRMYSYDRILASKKNLDHVNKILKAKKLQRQSRTGNNFVKRRPGRPRK 1569

  Fly  1063 WP------AIILP--PTEVPSNILKKAHGENDFVVRFFGTHDH---GW----------ISRRRVY 1106
            :|      |.:.|  .::..::::       :.||:.....|.   ||          :.:|...
 Frog  1570 YPVDSLQAAQLFPIMRSDTVTDVI-------EAVVQSVSLRDEQHKGWKRKHLELDKQVKKRPKS 1627

  Fly  1107 LY-----------------------IEGD-----TGDGHKT--------------------KSQL 1123
            ||                       |.|:     .||...|                    |:.|
 Frog  1628 LYEDDQESNISLSECAIVEAPAAPDISGNPEVERAGDLLHTMAPPPQKQKKAPRPPKKKYQKAGL 1692

  Fly  1124 FRNYTTGVEEASRFLPIIKARRQEQDMERQSG-------------------------------NK 1157
            |.:....::..||.:.:.|.:.:....|.:.|                               |:
 Frog  1693 FSDMYKTLDPKSRLVQLKKEKLEYDPREHEYGLLPAPIHIGKYLRQKRNDFQLPYDILWQWKHNQ 1757

  Fly  1158 LHPPP----YVKIKTN--KAVPPLRFSQNLEDLSTCNC-LPVDEHPCGPEAGCLNRMLFNECNPE 1215
            |:..|    |.||::|  ..|.||    :..:.:.||| .|.::...|....|||||:|.||:|.
 Frog  1758 LYKKPDVPLYKKIRSNVYVDVKPL----SGYEATMCNCKCPDNQSEKGCVEDCLNRMIFAECSPN 1818

  Fly  1216 YCKAGSLCENRMFEQRKSPR-LEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRR-ME 1278
            .|..|..|.|:..::.:..: ||......:|:|:..:||:....|:|||:|||::..||:.| :|
 Frog  1819 TCPCGEQCNNQCIQRHEWVQCLERFRAEGKGWGIRTKEPLKASQFIIEYLGEVVSETEFRNRTIE 1883

  Fly  1279 QKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVN 1343
            |.....|  :|.|.::...:||:...||.|||:||||:||||.|||:||.::|:|::|:||:|..
 Frog  1884 QYHNHSD--HYCLSLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAG 1946

  Fly  1344 SELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK---------DDAVKAHAKL---KQMRRAK 1396
            :|||::|.:.......::.|.||.::|.|.||||.:         ...|.:..:|   |:.|::|
 Frog  1947 TELTYDYNFHSFNTEKQQVCKCGVEKCRGIIGGKSQRVNGLANKGGHLVPSQRRLGRSKEKRKSK 2011

  Fly  1397 --------------ASAV--------RIHVKPKKTPK----VKH 1414
                          :.|:        ::|:||....:    :||
 Frog  2012 HRLKKRKGHFPEDRSDAIGTPSRLGPQLHMKPMSNRERNFVLKH 2055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	18/118 (15%)
		PHD2_NSD	867..932	CDD:277040	17/78 (22%)
		PHD3_NSD	933..988	CDD:277041	14/108 (13%)
		PHD4_NSD	1001..1041	CDD:277042	9/63 (14%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	28/192 (15%)
		AWS	1183..1233	CDD:197795	18/50 (36%)
		SET_NSD	1233..1375	CDD:380950	56/143 (39%)
ash1l	XP_031747239.1	PHA03307	25..>408	CDD:223039
		AWS	1785..1836	CDD:197795	18/50 (36%)
		SET_ASH1L	1839..1979	CDD:380951	57/141 (40%)
		Bromo_ASH1	2132..2237	CDD:99955
		PHD_ASH1L	2275..2317	CDD:277023
		BAH_polybromo	2354..2488	CDD:240068