Protein Alignment NSD and kmt2b

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_002940678.3
• Gene: kmt2b / 100144721
• XenbaseID: XB-GENE-853845
• Length: 2817
• Species: Xenopus tropicalis
• Alignment Length: 1372
• Identity: 267/1372 - (19%)
• Similarity: 419/1372 - (30%)
• Gaps: 488/1372 - (35%)

  Fly    95 QKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSA 159
            |:|.:..|.......|...:::|.||          |.|...|....:....:.|.:|....|..
 Frog  1833 QEQNKTIVHSPGPLPDPTEMEAAFSP----------PLPADTSSSCGQPPPLQPNTSATAPRSFI 1887

  Fly   160 GETLAHDNASP-RTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFE---AGSED 220
            |..:...|.|| |.|.||.            |:...||          .||.|:...   ....|
 Frog  1888 GARMKTPNYSPSRRPLGGS------------SRPLPSP----------GSPTSSSLSHHILTVSD 1930

  Fly   221 LGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKS-VKTEP-IDEEVDRTDEAPTQEAQTT 283
            ..:.|:     :|..:.||.::.......::.:|....| :...| |.......:|.||..:...
 Frog  1931 PEVTPL-----RRTRRPVPPSRFNAPSSTRSPEETTSPSPLPARPVIRHRATSENEVPTPASCGG 1990

  Fly   284 AISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASS 348
            |..::..:.::..|.:                .|..:..||.:|.....|:..::..:.|   :.
 Frog  1991 ASEVEVMSSSDGGALL----------------GPCGAQLIVGSEGDSSSEEDADDQYYGL---TR 2036

  Fly   349 TEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMV 413
            |.|        |...:::...|.|||.|....|:...||.       .|...|        ||
 Frog  2037 TVV--------SGDKISSMPASASSVHIRQLDGIHDSTDS-------EDGSQG--------PC-- 2076

  Fly   414 CPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREEL 478
              .|:|.  |..|||          :|.:: |.|.                   ||...:....:
 Frog  2077 --GPIGG--GKTPSH----------IPSEI-VEFV-------------------LKNTGNSESSI 2107

  Fly   479 RIKH-GP------KSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSD--RLEKFYQTYENVVTL 534
            ::.| ||      .|:.........|.:.....|:....:....|..|  :|::......:|.|.
 Frog  2108 QLHHIGPPASVASSSSSSSAQNGDATLLSNGNGAVSRQPSQGPPPLRDPPQLQRVCHPLISVPTK 2172

  Fly   535 NRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPF---------------- 583
            |          ..|...|..::......|.||.|..|:.|:...:|.|.
 Frog  2173 N----------TYDAPPVSVNVPTPKVILLNKMGQVLVKVENGNAEQPLLRETSKAERVTALALP 2227

  Fly   584 -SPAFSPVK--SKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVM 645
             .||...||  .||.|                 |.::..|....|.:..|
 Frog  2228 KLPAVKHVKVAPKNAK-----------------NPLSGLPHPQPTPLSPS--------------- 2260

  Fly   646 EYVMMNRSDEKVEKVLLSVVSNI-----WSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGT 705
                ||       .|:|...|:|     |:|....:|.:           |:.:.:.|.|.
 Frog  2261 ----MN-------TVILQATSSINPGQSWTLSTPVVRVV-----------PMLNVMQGTGQ---- 2299

  Fly   706 IKRLSNRLMTMMVRRSMTPVVT----------------------------PSTTPAPSEPDRRLS 742
                    :|:..:..|||.:|                            |...||| :|..||.
 Frog  2300 --------ITLGTQALMTPAITGIPQTCLLQNVPINSGVLSVASSVQPQQPQLKPAP-QPQARLQ 2355

  Fly   743 EPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLE 807
            ..|:.......|::     ::.|.|..    |.|.|:             .|.||     ....:
 Frog  2356 VQPQLSVLQPTPVK-----VVSLPSLC----LKRPPL-------------PSSTC-----FPVKK 2393

  Fly   808 RKVTGAPMPKIGSRKALVIPPTSKSPSPD------------EDHVTADAKEVVAVGTSLVCHECN 860
            .|:.....||:|.:..:.:..:|...|.|            ...:.|...:.|...|||...|.:
 Frog  2394 PKLEQTDGPKVGDKTDISVISSSVVLSADPASSSVAGTRLNRARIKAPMVQEVLDLTSLKDEEQS 2458

  Fly   861 VGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQ-ASSSK 924
            :.  :|..|       .:....:.|||...||::...|  :.|:          :|.|. .:..:
 Frog  2459 LN--DGLFI-------DLTLAVKDEDSQEETPVDSPSL--APPL----------EYIPNFENEEE 2502

  Fly   925 HSARCPR----HVCHTCVSDDPSGKFQQLGSSKLA-KCV-------RCPATYHQLS-KCIPAGTQ 976
            ..:..||    ::.....|:|  |.:.|..|::.| |.|       |.......|| .....||:
 Frog  2503 KKSSVPRRDGPYLRFEITSED--GFYIQADSAEDAWKAVLEKVQETRGVGKLRHLSLSASMIGTR 2565

  Fly   977 MLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEEC 1041
            |...              .|..||:....:.|.|             .||..
 Frog  2566 MFGV--------------QHDAVLFLLEQLTGAE-------------RCRGY------------- 2590

  Fly  1042 ESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVY 1106
                          ||         :..|.||       ..||       ..|:..| .:|..||
 Frog  2591 --------------KF---------LFHPQEV-------EEGE-------ISTNPSG-CARSEVY 2617

  Fly  1107 LYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKA 1171
            :         .|:...:| |:   :....|.||.|....:|::             .|::|:.:.
 Frog  2618 V---------RKSTFDMF-NF---LASQHRTLPEIGPCEEEEE-------------EVQLKSTRR 2656

  Fly  1172 VPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRL 1236
            ...|       ||              |.|     |.|...                 ::.|...
 Frog  2657 ATSL-------DL--------------PMA-----MRFRHL-----------------KKTSKEA 2678

  Fly  1237 EVVYMNE-RGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIID 1300
            ..||.:. .|.||..:..|..|:.||||.|.||......:| |:....:....|...::...::|
 Frog  2679 VGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKR-EKFYDSKGIGCYMFRIDDFDVVD 2742

  Fly  1301 AGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLW--DDLMNNSKKAC 1363
            |...||.|||:||||||||.::...|.....:.|||::.|....|||::|.:  :|..|  |..|
 Frog  2743 ATMHGNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRSIYRGEELTYDYKFPIEDASN--KLPC 2805

  Fly  1364 FCGAKRC 1370
            .||||:|
 Frog  2806 NCGAKKC 2812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	21/125 (17%)
		PHD2_NSD	867..932	CDD:277040	12/69 (17%)
		PHD3_NSD	933..988	CDD:277041	14/63 (22%)
		PHD4_NSD	1001..1041	CDD:277042	4/39 (10%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	19/94 (20%)
		AWS	1183..1233	CDD:197795	6/49 (12%)
		SET_NSD	1233..1375	CDD:380950	51/141 (36%)
kmt2b	XP_002940678.3	zf-CXXC	1011..1058	CDD:366873
		PHD1_KMT2B	1233..1279	CDD:277064
		PHD2_KMT2A_like	1281..1330	CDD:276982
		PHD3_KMT2B	1367..1423	CDD:277068
		Bromodomain	1406..1548	CDD:445827
		ePHD_KMT2B	1617..1721	CDD:277164
		FYRN	1768..1815	CDD:461787
		PHA03307	1824..>2091	CDD:223039	69/352 (20%)
		DUF5585	<2215..>2395	CDD:465521	45/273 (16%)
		FYRC	2512..2595	CDD:461788	23/147 (16%)
		SET_KMT2A_2B	2664..2817	CDD:380947	54/174 (31%)