DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and nsd2

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_002936809.1	Gene:	nsd2 / 100125213	XenbaseID:	XB-GENE-988824	Length:	1298	Species:	Xenopus tropicalis

Alignment Length:	1340	Identity:	383/1340 - (28%)
Similarity:	565/1340 - (42%)	Gaps:	334/1340 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 PIEKL-----LIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDE------ 249
            |.|||     .:.||         |:|:::                    |||..|..|
Frog    55 PTEKLKDLTSRVFNG---------ESGAQE--------------------AKVRFEAQEVQGIET 90

  Fly   250 -------KN-QQEVDEKSVKT----EPIDEEV---DRTDEAPTQEAQTTAISIKSETEAEHKAAV 299
                   || ..|:..|..||    :|:.|..   ||.:|.|..|.:      ||:...:.|
Frog    91 PPSTTPTKNGSPEIKLKITKTYMNGKPLFESSICGDRGEEEPQPEQK------KSKRGRKRK--- 146

  Fly   300 DVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTAL 364
                                    :||.|..  |||:.|    :|..|.:.   |..|...|..|
Frog   147 ------------------------IITSEAN--EKSSSE----MPSHSESS---KMKPVSESEFL 178

  Fly   365 ATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHP 429
            ....|...|:.                 |.|||:.|.||..|.:|||||..||:      :.||.
Frog   179 EHKNKEDFSLK-----------------YSVGDVVWSKVSGYPWWPCMVTSDPV------LYSHT 220

  Fly   430 QRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVP 494
            :... ...||. |.||:||.:...|.||..::::.|.|...:|.:.:|...:...|:.|.:.:.|
Frog   221 KVKG-QKKNVR-QYHVQFFGNAPERAWISEKSMVPFKGENEYDHLCQESAKQAPTKAEKTKLLKP 283

  Fly   495 KRTKV-VIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYD 558
            ...|: ..|...||:|:....:...:|.|||...|         .:.|.:...:..|:||..:..
Frog   284 ITGKIRAQWDIGIEQAKEGILMTPEERKEKFTFIY---------IKDRPQLNPRVASEVGVPVES 339

  Fly   559 STDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQT 623
            |..:..:.|.....:.||.|...      :|..||....|.:...:.|.|..:....|....|:.
Frog   340 SEKSTESPQKEGSSSYKRRRVSR------TPAASKEVDPADKTTTAKGPENSSDPKGMTSPASKK 398

  Fly   624 ETTVDSSAYENPEFRQLLSAVMEYVMM-------------NRSDEKVEKVLLS---VVSN----- 667
            .    |.|| .|..|: ..||.::::.             :.|||::|::|.|   ::||
Frog   399 R----SGAY-TPRSRK-GDAVNQFLVFCQKHKDEVINEHPDASDEEIEELLESQWNMLSNKQKAR 457

  Fly   668 -------------------IWSLKQIQLRELERDLASGEIEE----------------------- 690
                               :...|:..|:.........||:|
Frog   458 YNTKFAILTSPKSEEDSGSLHGHKRNHLKTTHNQTEDSEIQESPRKRLRMHNRKQRETCKPPKAR 522

  Fly   691 ---PLGSSVV--------------GRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPD 738
               |:.:|..              .|.|.:|::        .:.|.:|.:|........:.|:.|
Frog   523 ASAPVKNSPAMFSLSDACKPLKKRNRSSTLGSV--------ALPVSKSSSPASLTENEVSDSQGD 579

  Fly   739 RRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHA 803
            .|...|.::       .:|...:|..|..|.....:.:|.:|:.|.:.| ||:.|...|.|..|.
Frog   580 ERSESPSES-------ADESQAEISMLHRKSERGAMKKELVCQVCEKVG-DLMLCEGVCCSAFHL 636

  Fly   804 DCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCV 868
            .|:                .|...|..|                      .:|.||..| ...|.
Frog   637 SCI----------------GLSTRPAGK----------------------YLCKECTSG-ARSCF 662

  Fly   869 ICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHV 933
            :|             ||.:..       :..|..|.|||.:|.||.:.:|.|.......|||.|.
Frog   663 LC-------------KESNRD-------VKRCIVPHCGKFYHESCLRKYPLAVFESRGFRCPLHR 707

  Fly   934 CHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH---NIAKA-D 994
            |.||...:||.  .:....|:.:|||||..||....||.||...|.:|:|||..|   |.||: .
Frog   708 CATCYFSNPSN--PRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFAANKAKSHH 770

  Fly   995 AHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNN 1059
            ||:||.||::|..||.|:|||:||.|.|..|.||.: .:.|:.|.:|..|:.|.:.:|:|.|..|
Frog   771 AHINVSWCFVCSNGGSLLCCESCPAAFHPDCLNIEM-PDGSWFCNDCRLGKKPRFNDIIWVKLGN 834

  Fly  1060 FRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGH---KTKS 1121
            :|||||.:..|..||.||.|..|...:|.|.|||:.|:.|..:.||:.|:|||.|..|   |:..
Frog   835 YRWWPAEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSKHHGGKSIG 899

  Fly  1122 QLFRNYTTGVEEA-SRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLR-FSQNLEDL 1184
            ::|:|   .::|| :||..|::.|..:...|    |:..||||..||.||....:: ::.::.::
Frog   900 KVFKN---ALQEAETRFCEIMRQREAKVTQE----NEKKPPPYKHIKVNKPYGKVQVYTADISEI 957

  Fly  1185 STCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLV 1249
            ..|||.|..|.|||.::.||||||..||:|:.|.||..|:|:.|.:|:.|..:::....:|:||:
Frog   958 PKCNCKPSSEKPCGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLI 1022

  Fly  1250 NREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHS 1314
            ....|..|:||.||:||:|:..|...|:...|.:...::|.|.::||.|||||||||.:||||||
Frog  1023 ATRDIKKGEFVNEYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHS 1087

  Fly  1315 CEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK 1379
            |:||||||||:||...|||:||::|||...||||||.. |.:.|.|..|.|||..|||.:|.:.|
Frog  1088 CQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFNYNL-DCLGNEKTICRCGAPNCSGFLGDRPK 1151

  Fly  1380 DDAVKAH-AKLKQMRRAKASAVRIHVKPKKTPKVKHISAD 1418
            ::...:| .|:|              ||||..|.:....|
Frog  1152 NNTASSHEEKVK--------------KPKKKQKKRRTKTD 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	37/117 (32%)
		PHD2_NSD	867..932	CDD:277040	17/64 (27%)
		PHD3_NSD	933..988	CDD:277041	22/54 (41%)
		PHD4_NSD	1001..1041	CDD:277042	18/39 (46%)
		WHSC1_related	1047..1141	CDD:99899	39/97 (40%)
		AWS	1183..1233	CDD:197795	24/49 (49%)
		SET	1234..1354	CDD:214614	60/119 (50%)
nsd2	XP_002936809.1	MSH6_like	188..307	CDD:99898	39/143 (27%)
		HMG-box	414..463	CDD:238037	8/48 (17%)
		TNG2	<484..654	CDD:227367	35/223 (16%)
		PHD1_NSD1_2	613..655	CDD:277118	15/80 (19%)
		PHD2_NSD2	660..706	CDD:277121	17/65 (26%)
		PHD3_NSD2	707..760	CDD:277124	22/54 (41%)
		PHD4_NSD2	777..817	CDD:277127	18/40 (45%)
		WHSC1_related	822..916	CDD:99899	39/96 (41%)
		AWS	967..1004	CDD:375420	19/36 (53%)
		SET_NSD2	1006..1147	CDD:380988	70/141 (50%)
		PHD5_NSD2	1185..1227	CDD:277130
		C5HCH	1226..1273	CDD:375464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4428
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38976at33208
OrthoFinder	1	1.000	-	-		FOG0001511
OrthoInspector	1	1.000	-	-		otm47573
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010