Protein Alignment NSD and nsd3

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_694414.7
• Gene: nsd3 / 100006350
• ZFINID: ZDB-GENE-050324-2
• Length: 1563
• Species: Danio rerio
• Alignment Length: 1442
• Identity: 380/1442 - (26%)
• Similarity: 581/1442 - (40%)
• Gaps: 390/1442 - (27%)

  Fly   190 SKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQE 254
            |...:||.|. .|.|....|.:|             |:....|:...  |:.|:.:....:|.:|
Zfish   194 SPPLLSPQES-TISNPIGQPVNT-------------IITTTPKKTSS--PEIKLKIIKTYQNGRE 242

  Fly   255 VDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETE----AEHKAAVD-----VHIKQEDTIR 310
            :.|.|:..:.: :|....:::..|..|      |.|..    :.|.|..:     ..:::|.::
Zfish   243 LFESSLCGDLL-QEFQAGEDSRRQHEQ------KKEKRKKRGSRHGAGQEESQQPSKVEEERSV- 299

  Fly   311 LDIVNNPVESTSIVIT----EEPKDLEKSTEELAFALPLASSTE--VDLKSPPDLSSTALATSIK 369
              :|:|||::|...:.    ::|:...||        |.|...|  |:...|..::||..:..
Zfish   300 --VVHNPVQTTESQVAFREEQQPQSSLKS--------PKAELKEQKVEKHCPSVITSTGTSQE-- 352

  Fly   370 SPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSL 434
                                   |::|||.|.||.:|.:|||||..||...:...:
Zfish   353 -----------------------YEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRI--------- 385

  Fly   435 DNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKV 499
             |.....:.||:||.....|.||..:..:.:.....||:::.|...|....:.|.:.:.|:..|.
Zfish   386 -NTRGCKEYHVQFFGSVPERAWIHEKRTVVYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKE 449

  Fly   500 -VIWRQAIEEAQAMTQIPYSDRLEKFYQTY--------------------------ENVVT---- 533
             ..|...:..|:|..|:...:|.|.:...|                          .:.||
Zfish   450 RAQWEVGVGHAEAALQMTREERNENYTFIYIDKEPGADAETAAAPAPAPDSAPTAPTDTVTSPKA 514

  Fly   534 --LNRQKRK---------------------RTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVK 575
              .||.:||                     |.:..|....:..|.          .||..  |::
Zfish   515 TAKNRPERKQRRSRGSAGAKEEPIPRRQQPRRQCSMNSVGETSSP----------NQGED--AME 567

  Fly   576 RERSESPFSPA-------------------------------------------------FSPVK 591
            :|:..||..||                                                 ..|.|
Zfish   568 QEQPCSPPKPAPRPKEPSPPPVRTPWRTAAARKLLPLSITMKKLNVEIIKCDWQLPKQKVELPKK 632

  Fly   592 SKNEKRAKRR-----KLSNGTEADTGSN--SMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVM 649
            :::|:|...|     ..||..||:|.|:  ..|.:||.......:||.::.|.:|...:|.....
Zfish   633 TESEERPSSRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQEHTSAEQSTERKQQRRSVRSRSE 697

  Fly   650 MNRSDEKVEKVLLSVVSNIWSLKQIQLRELE----RDLASGEIEEPLGSSVVGRGSGVGTIKRLS 710
            ..:|.|.|.|            |:::..:.|    .|..:|..:   |:|.:.     .:.|.|.
Zfish   698 SEKSVEPVPK------------KKVKKEQAETAPQMDFKTGSQK---GASEIS-----DSCKPLK 742

  Fly   711 NRLMTMMVRRSMTPV-VTPSTTPAPSEPDRRLSEPPKT--KKPVNRP--IEEVIEDILQLDSKYL 770
            .|      .|:.|.| :..|.....|:.|.|....|:|  .|..:.|  ::....|...:||...
Zfish   743 KR------SRASTDVEMASSLYRDTSDSDSRGLNDPQTGFGKRSDSPATVDADGSDAQSVDSSLS 801

  Fly   771 FRGLS---REPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKS 832
            .:|.|   ::.:|..|...|..||.|...|:...|.:|:            ||.
Zfish   802 RQGGSSSKKDTVCHVCETFGDSLVSCEGDCNRLFHPECM------------GSN----------- 843

  Fly   833 PSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKL 897
                      ..||     :..||.||..|. ..|..|...|.                    .:
Zfish   844 ----------SGKE-----SETVCQECKTGS-HPCFSCKVTEG--------------------DM 872

  Fly   898 LTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPA 962
            ..||...||:.:|.:|.:.:..::|.....|||:|.|.||..|   ...|:.|..::.:|:|||.
Zfish   873 KRCSVNGCGRYYHETCVRKYTGSASDTKGLRCPQHSCATCCLD---RDLQKAGKGRMMRCIRCPV 934

  Fly   963 TYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAH----VNVLWCYICV----------------- 1006
            .||....|:.||:.::....|||..|:.::.:.|    |||.||:||.
Zfish   935 AYHTGDGCVAAGSVLITPHIIICSNHSSSRKNGHFSSPVNVGWCFICARGLLVHDHTDTILSSYT 999

  Fly  1007 ---------------------------------KGGELVCCETCPIAVHAHCRNIPIKTNESYIC 1038
                                             |||.|:|||.||.:.|..|..|.:... :::|
Zfish  1000 FKSHYLLTESNRAELMKLPMIPSSSSATKKNIGKGGRLLCCEACPASFHPECLKIEMPEG-TWLC 1063

  Fly  1039 EECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRR 1103
            .||:||:.|.|.:|||.|..|:|||||.|..|..|||||....|...||.|.|||:||:.||::.
Zfish  1064 GECKSGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQG 1128

  Fly  1104 RVYLYIEGDT--GDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKI 1166
            ||:.|:|.|.  .:|....::.|:.   .:|||::....:||:|:.::...|..|...||||..|
Zfish  1129 RVFPYVESDKNFAEGQVGINKTFKK---ALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLI 1190

  Fly  1167 KTNKAVPPLRFS-QNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQ 1230
            |:||....::.. .:|.::..|||.|.||.||..::.||||||..||:|:.|.||..|.|:.|.:
Zfish  1191 KSNKPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSK 1255

  Fly  1231 RKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEK 1295
            |..|..||:....||:||..::.:..||||:|||||:|:..|.::|:.....:...|:|.|.:.|
Zfish  1256 RLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTK 1320

  Fly  1296 DFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSK 1360
            |.:|||||||||:|||||||.|||||||||||...|:|:|.:.||..::||||||.. |.:.|.:
Zfish  1321 DRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNL-DCLGNGR 1384

  Fly  1361 KACFCGAKRCSGEIGGKLKDDAVK------AHAKLK-QMRRAKASAVRIH--------------- 1403
            .:|.||::.|||.:|.|.|...|.      .:|||| :.|:.|..:.:.|
Zfish  1385 TSCHCGSENCSGFLGVKPKSAVVMEREEKVRNAKLKPKKRKLKTESKQTHELYCYCCGEGGELVM 1449

  Fly  1404 VKPKKTPKVKHI 1415
            ...|..||..|:
Zfish  1450 CDKKDCPKAYHL 1461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	32/119 (27%)
		PHD2_NSD	867..932	CDD:277040	13/64 (20%)
		PHD3_NSD	933..988	CDD:277041	18/54 (33%)
		PHD4_NSD	1001..1041	CDD:277042	17/89 (19%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	39/96 (41%)
		AWS	1183..1233	CDD:197795	24/49 (49%)
		SET_NSD	1233..1375	CDD:380950	70/141 (50%)
nsd3	XP_694414.7	None