DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD and nsd3

DIOPT Version :9

Sequence 1:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster
Sequence 2:XP_005155379.1 Gene:nsd3 / 100006350 ZFINID:ZDB-GENE-050324-2 Length:1563 Species:Danio rerio


Alignment Length:1435 Identity:381/1435 - (26%)
Similarity:579/1435 - (40%) Gaps:376/1435 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   190 SKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQE 254
            |...:||.|. .|.|....|.:|             |:....|:...  |:.|:.:....:|.:|
Zfish   194 SPPLLSPQES-TISNPIGQPVNT-------------IITTTPKKTSS--PEIKLKIIKTYQNGRE 242

  Fly   255 VDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIK--SETEAEHKAAVDVHIKQEDTIRLDIVNNP 317
            :.|.|:..:.: :|....:::..|..|......|  |...|.|:.:......:|:  |..:|:||
Zfish   243 LFESSLCGDLL-QEFQAGEDSRRQHEQKKEKRKKRGSRHGAGHEESQQPSKVEEE--RSVVVHNP 304

  Fly   318 VESTSIVIT----EEPKDLEKSTEELAFALPLASSTE--VDLKSPPDLSSTALATSIKSPSSVSI 376
            |::|...:.    ::|:...||        |.|...|  |:...|..::||..:..         
Zfish   305 VQTTESQVAFREEQQPQSSLKS--------PKAELKEQKVEKHCPSVITSTGTSQE--------- 352

  Fly   377 DSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPI 441
                            |::|||.|.||.:|.:|||||..||...:...:          |.....
Zfish   353 ----------------YEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRI----------NTRGCK 391

  Fly   442 QVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKV-VIWRQA 505
            :.||:||.....|.||..:..:.:.....||:::.|...|....:.|.:.:.|:..|. ..|...
Zfish   392 EYHVQFFGSVPERAWIHEKRTVVYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKERAQWEVG 456

  Fly   506 IEEAQAMTQIPYSDRLEKFYQTY--------------------------ENVVT------LNRQK 538
            :..|:|..|:...:|.|.:...|                          .:.||      .||.:
Zfish   457 VGHAEAALQMTREERNENYTFIYIDKEPGADAETAAAPAPAPDSAPTAPTDTVTSPKATAKNRPE 521

  Fly   539 RK---------------------RTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESP 582
            ||                     |.:..|....:..|.          .||..  |:::|:..||
Zfish   522 RKQRRSRGSAGAKEEPIPRRQQPRRQCSMNSVGETSSP----------NQGED--AMEQEQPCSP 574

  Fly   583 FSPA-------------------------------------------------FSPVKSKNEKRA 598
            ..||                                                 ..|.|:::|:|.
Zfish   575 PKPAPRPKEPSPPPVRTPWRTAAARKLLPLSITMKKLNVEIIKCDWQLPKQKVELPKKTESEERP 639

  Fly   599 KRR-----KLSNGTEADTGSN--SMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEK 656
            ..|     ..||..||:|.|:  ..|.:||.......:||.::.|.:|...:|.......:|.|.
Zfish   640 SSRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQEHTSAEQSTERKQQRRSVRSRSESEKSVEP 704

  Fly   657 VEKVLLSVVSNIWSLKQIQLRELE----RDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMM 717
            |.|            |:::..:.|    .|..:|..:   |:|.:.     .:.|.|..|     
Zfish   705 VPK------------KKVKKEQAETAPQMDFKTGSQK---GASEIS-----DSCKPLKKR----- 744

  Fly   718 VRRSMTPV-VTPSTTPAPSEPDRRLSEPPKT--KKPVNRP--IEEVIEDILQLDSKYLFRGLS-- 775
             .|:.|.| :..|.....|:.|.|....|:|  .|..:.|  ::....|...:||....:|.|  
Zfish   745 -SRASTDVEMASSLYRDTSDSDSRGLNDPQTGFGKRSDSPATVDADGSDAQSVDSSLSRQGGSSS 808

  Fly   776 -REPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDH 839
             ::.:|..|...|..||.|...|:...|.:|:            ||.                  
Zfish   809 KKDTVCHVCETFGDSLVSCEGDCNRLFHPECM------------GSN------------------ 843

  Fly   840 VTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPM 904
               ..||     :..||.||..|. ..|..|...|.                    .:..||...
Zfish   844 ---SGKE-----SETVCQECKTGS-HPCFSCKVTEG--------------------DMKRCSVNG 879

  Fly   905 CGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSK 969
            ||:.:|.:|.:.:..::|.....|||:|.|.||..|   ...|:.|..::.:|:|||..||....
Zfish   880 CGRYYHETCVRKYTGSASDTKGLRCPQHSCATCCLD---RDLQKAGKGRMMRCIRCPVAYHTGDG 941

  Fly   970 CIPAGTQMLNTTNIICPRHNIAKADAH----VNVLWCYICV------------------------ 1006
            |:.||:.::....|||..|:.::.:.|    |||.||:||.                        
Zfish   942 CVAAGSVLITPHIIICSNHSSSRKNGHFSSPVNVGWCFICARGLLVHDHTDTILSSYTFKSHYLL 1006

  Fly  1007 --------------------------KGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGR 1045
                                      |||.|:|||.||.:.|..|..|.:... :::|.||:||:
Zfish  1007 TESNRAELMKLPMIPSSSSATKKNIGKGGRLLCCEACPASFHPECLKIEMPEG-TWLCGECKSGK 1070

  Fly  1046 LPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIE 1110
            .|.|.:|||.|..|:|||||.|..|..|||||....|...||.|.|||:||:.||::.||:.|:|
Zfish  1071 KPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVE 1135

  Fly  1111 GDT--GDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVP 1173
            .|.  .:|....::.|:.   .:|||::....:||:|:.::...|..|...||||..||:||...
Zfish  1136 SDKNFAEGQVGINKTFKK---ALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFG 1197

  Fly  1174 PLRFS-QNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLE 1237
            .::.. .:|.::..|||.|.||.||..::.||||||..||:|:.|.||..|.|:.|.:|..|..|
Zfish  1198 KVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTE 1262

  Fly  1238 VVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAG 1302
            |:....||:||..::.:..||||:|||||:|:..|.::|:.....:...|:|.|.:.||.:||||
Zfish  1263 VIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAG 1327

  Fly  1303 PKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGA 1367
            |||||:|||||||.|||||||||||...|:|:|.:.||..::||||||.. |.:.|.:.:|.||:
Zfish  1328 PKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNL-DCLGNGRTSCHCGS 1391

  Fly  1368 KRCSGEIGGKLKDDAVK------AHAKLK-QMRRAKASAVRIH---------------VKPKKTP 1410
            :.|||.:|.|.|...|.      .:|||| :.|:.|..:.:.|               ...|..|
Zfish  1392 ENCSGFLGVKPKSAVVMEREEKVRNAKLKPKKRKLKTESKQTHELYCYCCGEGGELVMCDKKDCP 1456

  Fly  1411 KVKHI 1415
            |..|:
Zfish  1457 KAYHL 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 31/117 (26%)
PHD2_NSD 867..932 CDD:277040 13/64 (20%)
PHD3_NSD 933..988 CDD:277041 18/54 (33%)
PHD4_NSD 1001..1041 CDD:277042 17/89 (19%)
WHSC1_related 1047..1141 CDD:99899 40/95 (42%)
AWS 1183..1233 CDD:197795 24/49 (49%)
SET 1234..1354 CDD:214614 62/119 (52%)
nsd3XP_005155379.1 PWWP 351..468 CDD:321985 34/151 (23%)
PHD1_NSD3 813..856 CDD:277119 16/80 (20%)
PHD_SF 861..907 CDD:328929 13/65 (20%)
PHD3_NSD3 908..960 CDD:277125 18/54 (33%)
PHD4_NSD3 1033..1066 CDD:277128 13/33 (39%)
WHSC1_related 1072..1165 CDD:99899 40/95 (42%)
AWS 1208..1258 CDD:197795 24/49 (49%)
SET 1259..1382 CDD:214614 63/123 (51%)
PHD5_NSD3 1437..1479 CDD:277131 4/25 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 132 1.000 Domainoid score I5064
eggNOG 1 0.900 - - E2759_KOG1081
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 502 1.000 Inparanoid score I1322
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D38976at33208
OrthoFinder 1 1.000 - - FOG0001511
OrthoInspector 1 1.000 - - oto39986
orthoMCL 1 0.900 - - OOG6_102558
Panther 1 1.100 - - LDO PTHR22884
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X847
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1312.860

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