Protein Alignment NSD and ehmt1a

DIOPT Version :10

• Sequence 1: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_005171835.2
• Gene: ehmt1a / 100005761
• ZFINID: ZDB-GENE-040724-44
• Length: 1059
• Species: Danio rerio
• Alignment Length: 1117
• Identity: 233/1117 - (20%)
• Similarity: 356/1117 - (31%)
• Gaps: 378/1117 - (33%)

  Fly   458 KPENL--LTFAGLKAFDDMREELRIKHGPKSAKY--RQMVPKRTKVV-------IWRQAIEEAQA 511
            |||.|  .:|..    |:..:.:.:...|::|:.  .|..|:..|||       .|:..:..|.|
Zfish    75 KPETLEKQSFGS----DNADKRITVVSVPEAAREEDEQREPEGVKVVKPAPPRLAWKTMVRSAPA 135

  Fly   512 MTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSS----------LYDSTDNLHNK 566
            ...:.                ||||:   |:.|    ..||.||          |.|||.....|
Zfish   136 PPALK----------------TLNRE---RSGY----ERDVESSPTQHLSLPQELKDSTQTAPKK 177

  Fly   567 QGTQLLAVKRERSESPFSPAFSP---------VKSKNEKRAKRRKLSNG-----TEADTGSNSMA 617
            :       ||:.....|.|...|         :.|.|.:.|.|...|.|     .||.....|..
Zfish   178 K-------KRKMGLYNFVPKKKPKGSKKANVSLSSSNLQEALRMTGSKGGQMSIEEAFRNKASSE 235

  Fly   618 VTPSQTETTV--DSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVV-SNIWSLKQIQLRE- 678
            ....||.|.|  |:..::|.|        .|......::|..|..|.::. .::::.....|||
Zfish   236 KPKKQTSTAVIEDAEPHKNKE--------TEDAPEGPAEEYTELPLHALAHDSLFTAIPTGLRED 292

  Fly   679 ---------LERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAP 734
                     ||..|.|..:|.|....||                 |:...:.|          |.
Zfish   293 KENMETDDTLEPPLCSCRMETPKNQDVV-----------------TLAEGKCM----------AV 330

  Fly   735 SEPDRRLSEPPKT--KKPVNRPIEEVIEDILQLDSKYLFRGLSRE---PICKYCYQAGSDLVRCS 794
            ...|.:||...|.  |:.:.||...:.:.:|..|.:   .|:.:.   |.|.:..:||: .:.|.
Zfish   331 ESVDGKLSLCRKVIMKQELMRPSLRIPQLVLCEDHR---AGMVKHQSCPGCGFFCRAGT-FMECQ 391

  Fly   795 ----------RTCSSWLHAD--CLERKVTGAPMPKIGSR----KALVIP--------PTSKSPSP 835
                      |:|:|.:...  |          |..|..    |.:.||        ||:..|:.
Zfish   392 PDGNISHRFHRSCASLIRGQVYC----------PHCGEEASHAKEVTIPKPDCVASVPTAAVPAH 446

  Fly   836 DEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAV----PSTPRKED-SSSHTPIED 895
            ..|:...|                            :|:|.:|    ...|.||. .:....:||
Zfish   447 KRDNALMD----------------------------RVKSDSVMVDGAGDPAKESLENVLNALED 483

  Fly   896 ------KLLTCSQPMCGKR------FHTSCCKYWPQASSSKHSARCPRH---------VCHTCVS 939
                  ||.........||      .|.......|.........:.|.|         :||..|
Zfish   484 GKYKKFKLPPKQLYFSAKRGELQRILHMLVEGVDPNLRMDSEKRKTPLHCAAEEGHKDICHVLV- 547

  Fly   940 DDPSGKFQQLGSSKLAKC---VRCPATY-------HQLSKCIPAGT-----QMLNTTNIICPRHN 989
                    |.|:: |..|   .|.|..|       ..:...:.||.     .|..:|.:    |.
Zfish   548 --------QAGAN-LDMCDIEQRTPLMYACNNNHLENVKYLLKAGASSAHKDMRGSTCL----HL 599

  Fly   990 IAKADAHVNVLWCYICVKGGELVC-----------------CETCPIAVHAHCRNIPIKTNESYI 1037
            .|:| .|.|||...:.:...::.|                 .|...:.:.|.. ::.|:..|..:
Zfish   600 AARA-GHTNVLQYLLSLPSIDVNCKDDGGWAPLTWATENMRLEQVKMLISAGA-DVQIRDKEENL 662

  Fly  1038 CEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILK--------KAHGEN--------- 1085
            |             :.||.|:..          .|:...:|.        ..||:.
Zfish   663 C-------------LHWAAFSGC----------DEIAQLLLDHRSDLHAVNVHGDTPLHIAVRQN 704

  Fly  1086 --DFVVRFFGTHDHGWISRRRVYLYIEGDTGDG---HKTKSQLFRNYTTGVEEASRFLPIIKARR 1145
              |.|:.|........:..|      :|:|..|   ..:|.....|....:.:|.|....::.|.
Zfish   705 QLDCVMLFLSRGADVNLKNR------DGETPLGCCNINSKMWTILNTNKKLTDARRGRESLRERL 763

  Fly  1146 QEQDMERQSGNKLHPPPYVK-------------IKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPC 1197
            ..:|:.|  |.:..|.|.|.             |..|.....:...:|::.|..|:|    :..|
Zfish   764 LCRDVSR--GYEDIPVPCVNGVDHEPCPSNFKYIPENCFTSQVNIDENIKHLQHCSC----KDDC 822

  Fly  1198 GPEAGCL-------------NRML----------FNECNPEYCKAGSLCENRMFEQRKSPRLEVV 1239
            . .:.|:             .|:|          ..||| ..|.....|.||:.:.....||:|.
Zfish   823 A-SSSCICGQLSMHCWYGKDGRLLKEFCRDDPPFLFECN-HACSCWRTCRNRVIQNGLRLRLQVF 885

  Fly  1240 YMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYF---LGVEKDFIIDA 1301
            .....|:|:...:.|..|.||.|:.||:|:..|...|       .:::|.|   ..|.:.:.||.
Zfish   886 RTERMGWGVRTLQDIPEGGFVCEFAGEIISDGEANIR-------ENDSYMFNLDNKVGEAYCIDG 943

  Fly  1302 GPKGNLARFMNHSCEPNCETQKWTVNCIH------RVGIFAIKDIPVNSELTFNYLWDDLMNNSK 1360
            ...||::|||||.||||....:  |...|      |:..||.|.|....||.|:| .|......|
Zfish   944 QFYGNVSRFMNHLCEPNLFPVR--VFTKHQDMRFPRIAFFASKHIQAGDELGFDY-GDHYWQIKK 1005

  Fly  1361 K--ACFCGAKRC 1370
            |  .|.||:.:|
Zfish  1006 KYFRCQCGSGKC 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	16/66 (24%)
		PHD2_NSD	867..932	CDD:277040	15/81 (19%)
		PHD3_NSD	933..988	CDD:277041	14/69 (20%)
		PHD4_NSD	1001..1041	CDD:277042	6/56 (11%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	18/116 (16%)
		AWS	1183..1233	CDD:197795	14/72 (19%)
		SET_NSD	1233..1375	CDD:380950	49/149 (33%)
ehmt1a	XP_005171835.2	None