DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD and nsd2

DIOPT Version :9

Sequence 1:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001076020.1	Gene:	nsd2 / 100000709	ZFINID:	ZDB-GENE-030131-2581	Length:	1461	Species:	Danio rerio

Alignment Length:	1499	Identity:	392/1499 - (26%)
Similarity:	606/1499 - (40%)	Gaps:	387/1499 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 SPT---PLSDSD-------DTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDS 184
            |||   .||||.       |.|......:|:||....::..|::      |:..|..|.....:.
Zfish    17 SPTSMKQLSDSPGGRNGLVDGITDPTMLMNKAATQLAATPQESV------PQMIGSHGHNHTHEH 75

  Fly   185 ANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDL-GIRPIVRKHVKRKMKRVPKAKVTLEL- 247
            ...|.|:......||:        |......||...| |:.| |.:|.....|.....::|:::
Zfish    76 LKDLTSRLLNGDTEKI--------PKLCAAPAGQPLLKGVEP-VSQHASPPRKTSVSPELTVKIT 131

  Fly   248 -------DEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAA------- 298
                   .:.|:.|||....|.|..|        ||.:..:....|..:..:.:.|..
Zfish   132 KCVVNLGGKPNRYEVDYTEEKAEETD--------APLRLPEGVLTSPTARRDRQKKKGMVRKRIP 188

  Fly   299 ---VDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLE-KSTEELAFALPLASSTEVDLKSPPDL 359
               :..|....|  :..:::..:.|..|.|  ||..|. :|.|.....:|...:...|.:...|.
Zfish   189 PYPILTHAASSD--QSPLLHPTINSNDITI--EPCGLPVESIEHTHGDMPTCVTAFPDEQPLSDC 249

  Fly   360 SSTALATSIKSPSSVSIDSAKGLSIVTDPGWPT-----YQVGDLFWGKVFSYCFWPCMVCPDPLG 419
            ..|..|..:.     ..|.|:|.:.|.:....|     :.|||:.|.||..|.:||||:..||
Zfish   250 EETVDAQGVD-----ETDDAQGENDVKESYTETQSNVHFSVGDVIWTKVSGYPWWPCMITTDP-- 307

  Fly   420 QIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIK--- 481
                ....| .||.: |:...:..||::|.|...|.::..:.::||:|...:..:....::.
Zfish   308 ----EFNMH-FRSKV-NSRTGLLYHVQYFGDTPERGYVFEKCIVTFSGKHQYQSLSRSNQLPINI 366

  Fly   482 HGPKSA---KYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTK 543
            .|.|.|   |:||.         |...:.:|:....:...:||.||...||:      .|.:...
Zfish   367 SGRKRAVPRKFRQK---------WEIGVSQAKEALGLLTEERLAKFSFVYED------GKAQLNP 416

  Fly   544 YMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSE-----SPFSPAFSPVKSKNEKRAKRRKL 603
            :|:|...:            ...||.|...|:||..|     .|.|...||..|....... ...
Zfish   417 HMLQVLEE------------QRNQGLQEEPVQREPQELVSLTPPDSTHSSPTNSSTTSTIP-SLF 468

  Fly   604 SNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNI 668
            ||..::.|.|...|:.....:.:|.::.      |:..|:.:|:::...|
Zfish   469 SNPIDSSTSSGKTALPRKARKPSVKTNR------RKQRSSTIEWIVTEAS--------------- 512

  Fly   669 WSLKQIQLRE------------------------LERDLASGEIE-EPLGS-------------- 694
             |.||:.|.|                        .::||...::: :|..|
Zfish   513 -SAKQMPLTESTVQCEVNTEHKKKGKTNAGKRPYRKKDLLCIDLDLQPKASQKKPRHIRQKFPAA 576

  Fly   695 -------------------SVVGRGSGVGTIKR------------LSNRLMTMMVRRS------- 721
                               :.|...:|:..:|.            .|::.|..:.:||
Zfish   577 PNSVKKRKIKAGVSICDTLNTVSTSAGLSEVKASAPSTKLWEKEDASSKGMKKVCKRSRESKQDV 641

  Fly   722 -MTP-------------------VVTPSTTPAP--------SEPDRRLSE-------PPKTKK-- 749
             :.|                   ...|:..|||        .:.:|:.|:       |||.|:
Zfish   642 TLQPKKKSKLEKDFKKWKCPKAASSAPAAVPAPRGRRRKTDRDENRKRSKKASKEEPPPKAKRGR 706

  Fly   750 -----------PVNR---------------PIEEVIEDILQLDSKYLFR--GLSREPICKYCYQA 786
                       |.::               |.:...|   ...||...|  |..:|.:|..|.|.
Zfish   707 KRKEESGRQSFPASKKCRPSSYAEPERPDSPSDSTDE---SHPSKKAERTPGAKKESVCLVCEQT 768

  Fly   787 GSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVG 851
            |.|:|.|:..|....|..|            ||..::                           .
Zfish   769 GEDIVTCAGQCYGTYHLHC------------IGVERS---------------------------A 794

  Fly   852 TSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKY 916
            ..::|..|:.| ...|..|.:.|.                    ::..|....||:.:|.:|.:.
Zfish   795 EKILCTACSTG-VHVCFTCKKSEG--------------------EVRRCCALHCGRFYHEACVRL 838

  Fly   917 WPQASSSKHSARCPRHVCHTCVSDDPSGKFQ-QLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNT 980
            ...........|||   .|||:|...||:.. :....|:.:|:|||..||....|:.||::|:::
Zfish   839 SALTVFENRGFRCP---LHTCLSCHYSGRAACKATKGKMMRCLRCPVAYHVGDLCVAAGSEMISS 900

  Fly   981 TNIICPRHNIAKA----DAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEEC 1041
            :.|:|..|..||.    .:||||.||:||.|||.|:|||:||.|.|..|.||.: .:.|:.|.:|
Zfish   901 SAIVCTNHFRAKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAM-PDGSWFCNDC 964

  Fly  1042 ESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVY 1106
            .||:.|.|.:::|.|..|:|||||.|..|..:|:||....|...:|.|.|||:.|:.|..:.||:
Zfish   965 RSGKKPKYRDVIWVKLGNYRWWPAEIRHPKNIPTNIQHLRHEIGEFPVFFFGSKDYFWTHQGRVF 1029

  Fly  1107 LYIEGDTGDGHKTK--SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQS----GNKLHPPPYVK 1165
            .|:|||.|..::..  .::|:|.....|  :||        :|.:|||::    .|...|||:..
Zfish  1030 PYMEGDRGSKYQQTGIGKVFKNALLDAE--TRF--------KEIEMEREAKEAHENNKKPPPFKY 1084

  Fly  1166 IKTNKAVPPLR-FSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFE 1229
            ||.||....:: ::.::.::..|||.|..|.||..|:.||||||..||:|:.|.||..|:|:.|.
Zfish  1085 IKVNKPCGRVQVYTADISEIPKCNCKPSTERPCSFESECLNRMLLYECHPQVCPAGERCQNQDFT 1149

  Fly  1230 QRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVE 1294
            :|..|..:::....:|:||::...|..|:||.|||||:|:..|.:.|:...|.:...::|.|.::
Zfish  1150 KRLYPETKIIRTAGKGWGLISLRDIKKGEFVNEYVGELIDEEECRSRIRHAQENDITHFYMLTID 1214

  Fly  1295 KDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNS 1359
            ||.|||||||||.:|||||||:|||||||||||...|||:||:.|||..:||||||.. |.:.|.
Zfish  1215 KDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNL-DCLGNE 1278

  Fly  1360 KKACFCGAKRCSGEIGGKLKD-DAVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHISADDEPMD 1423
            |..|.|||..|||.:|.:.|: ...:..|||:                ||.||.|.  |.:|...
Zfish  1279 KTVCRCGAPNCSGFLGDRPKNGHTSEPKAKLQ----------------KKKPKRKR--ARNEGKK 1325

  Fly  1424 AKDE 1427
            ::||
Zfish  1326 SEDE 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD	NP_733239.1	MSH6_like	391..508	CDD:99898	33/127 (26%)
		PHD2_NSD	867..932	CDD:277040	11/64 (17%)
		PHD3_NSD	933..988	CDD:277041	19/55 (35%)
		PHD4_NSD	1001..1041	CDD:277042	20/39 (51%)
		WHSC1_related	1047..1141	CDD:99899	35/95 (37%)
		AWS	1183..1233	CDD:197795	24/49 (49%)
		SET	1234..1354	CDD:214614	62/119 (52%)
nsd2	NP_001076020.1	PWWP	283..394	CDD:295359	33/127 (26%)
		DTHCT	688..>758	CDD:285332	12/72 (17%)
		PHD_SF	761..803	CDD:304600	13/80 (16%)
		PHD_SF	808..854	CDD:304600	11/68 (16%)
		PHD_SF	855..908	CDD:304600	18/52 (35%)
		PHD4_NSD2	925..965	CDD:277127	20/40 (50%)
		WHSC1_related	970..1063	CDD:99899	35/102 (34%)
		AWS	1103..1153	CDD:197795	24/49 (49%)
		SET	1154..1277	CDD:214614	63/123 (51%)
		PHD_SF	1329..1371	CDD:304600	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5064
eggNOG	1	0.900	-	-		E2759_KOG1081
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1322
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38976at33208
OrthoFinder	1	1.000	-	-		FOG0001511
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102558
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860