DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and GNPAT

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_055051.1	Gene:	GNPAT / 8443	HGNCID:	4416	Length:	680	Species:	Homo sapiens

Alignment Length:	741	Identity:	164/741 - (22%)
Similarity:	312/741 - (42%)	Gaps:	146/741 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 KFEYRQVTEIVH----------------NDAVLKHAIKQAAEQTLREQRYAKNGHRLLTRSASGD 175
            ||..:..|.:|:                |...:.:.|||.::::|:                |.|
Human    49 KFAMKCYTPLVYKGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQ----------------SVD 97

  Fly   176 QEAQEEEDEKRGISYQAILRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNTK 240
                             :||::   ...||.:|...|..|.:.|.::.|.|:.....|.|..|.:
Human    98 -----------------VLREE---VSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNEE 142

  Fly   241 QIEMLKTATERSPGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNN-LQIPVFGGLLRGL 304
            .|:.|:.|.:..   |::.:|.|||::|::|::::|.|.|:..|::|||.: |.:.:.|.|||..
Human   143 GIQKLQRAIQEH---PVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMS 204

  Fly   305 GAFFIKRKIDPVEGKKDVLYRAALHLYLTHALKQGH-NVEFFIEGGRTRTGKPCMPKGGILSVIV 368
            ||||::|...   |.|  ||.|....|:...|:.|: .||||:||.|:|:.|...||.|:|::::
Human   205 GAFFMRRTFG---GNK--LYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVM 264

  Fly   369 NAFMDGSIPDALLVPVSVNYERLVDGN-FVREQKGEKKIPESFGKAISGIWKA---LKSNYGLMR 429
            ..|....:.|..|||:|::|:::::.. :|.|..|..|..||    .:|:.||   |..|:|.:.
Human   265 EPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKES----TTGLLKARKILSENFGSIH 325

  Fly   430 IDFNEPYSIRELVNSYNKIAREDGNIAKVYKPSARVLQHNQSTSSLYGTDVVCEEHRNLIESISR 494
            :.|.:|.|:|.|  :..:::|...|:...|.|     |........:.|:|..:.....||::
Human   326 VYFGDPVSLRSL--AAGRMSRSSYNLVPRYIP-----QKQSEDMHAFVTEVAYKMELLQIENM-- 381

  Fly   495 QVVFDCAAATSVMSTNALAFLLLTRFRNGAEEQILSEA---LDDLRNSLSGCKDIGFSGESSQIV 556
                       |:|...|...:|.:.|...:...|.|.   |..|..:..|.. |....:.::.|
Human   382 -----------VLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFL-IWPDNKPAEEV 434

  Fly   557 AYACDLLGSGLVTRSRDENGRLVIKAVNSVESFIELAYYSNMLTPHFALSSILLTTFHSLLPETE 621
            ..|..||.|.:.:..:|:    ||..|:|.:|.:    ...::..|..|  ::.:.:       .
Human   435 VPASILLHSNIASLVKDQ----VILKVDSGDSEV----VDGLMLQHITL--LMCSAY-------R 482

  Fly   622 NKKEAAVSRKKLIDTALENCQIYRYEFILNKPTQVLENLLYQQLDDLLISGCVLTEKLHDDLPNG 686
            |:......|..|:..||:....:|.|.:.:         .::.|.|:.....:.       ||
Human   483 NQLLNIFVRPSLVAVALQMTPGFRKEDVYS---------CFRFLRDVFADEFIF-------LP-- 529

  Fly   687 AEGRRLANVLAECLDEDGYEDVRDGEADE---PKLLFASETPSQQRYICEVLAPFAWTYVTVAQS 748
                  .|.|.:.  |:|...:...||.:   ..:|...:..:...::..:..||..:|..:.:.
Human   530 ------GNTLKDF--EEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKY 586

  Fly   749 LQILHKNSMLESEFISFVINDLSSKVKRGSCIYAESISTDSVRNCLKLLEKWSVIEVCNQQGMRL 813
            |....::...|.::::.|....|..:.:|:....:.:|:|..:|.|....:..|:|      .:.
Human   587 LLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVE------KKK 645

  Fly   814 ISLNTLYEMSRESLNSIVKKIDAIVP 839
            |:.|.::.::..:...:.:.:....|
Human   646 INNNCIFNVNEPATTKLEEMLGCKTP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	136/547 (25%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	75/216 (35%)
GNPAT	NP_055051.1	PTZ00374	<62..608	CDD:240389	149/657 (23%)
		LPLAT_DHAPAT-like	134..339	CDD:153255	75/218 (34%)
		HXXXXD motif	162..167		3/4 (75%)
		Microbody targeting signal. /evidence=ECO:0000255	678..680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820