DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and Gpat2

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_017447069.1	Gene:	Gpat2 / 296130	RGDID:	1304904	Length:	828	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	189/805 - (23%)
Similarity:	309/805 - (38%)	Gaps:	172/805 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TLRSSNEPKTQNSVAH----------GIGTQNMLELTPHSGQ-KPF------------------K 107
            |:..|| |:.|....|          |.| ..|..:||..|: :||                  :
  Rat     3 TMLKSN-PQMQQRNNHSGQETSLWSSGFG-MKMEAITPFLGKYRPFMGRCCQTCTPKSWESLFHR 65

  Fly   108 KLFDWGVLFPYVAQVVRSEKFEYR--QVTEIVHNDAVLKHAIKQA--AEQTLREQRYAKNGHRLL 168
            .:.|.|  |..|. :|:.|...:|  .|..:.:....|:..|..:  |.|.:.|....:|  .||
  Rat    66 SIMDLG--FCNVI-LVKEENTRFRGWLVRRLCYFLWSLEQHIPTSSDASQMIMENTGVQN--ILL 125

  Fly   169 TR--SASGDQEAQEEEDEKRGISYQAILRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCF 231
            .:  .|:|:.:|.:            :::|:.||   ||..:.:|....||...||.|...|...
  Rat   126 GKVPGAAGEGQAPD------------LVKKEVQR---ILGHIQTTPRPFLLRLFSWALLWFLNRL 175

  Fly   232 LSGVVTNTKQIEMLKTATERSPGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPV 296
            ...|..:..|::|:..|.:.  |:||:|:..|:|.||..::.::|.:..:....||..:....|.
  Rat   176 FLNVQLHKGQMKMVHKAAQE--GSPLVFLSTHKSLLDGFLLPFVLFSQGLGVLRVALDSRTCSPA 238

  Fly   297 FGGLLRGLGAFFI----KRKIDPVEGKKDVLYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPC 357
            ...|||.||..|:    ...:|..||   :|.||.:...:...|..|..:..|:|......|...
  Rat   239 LRALLRKLGGLFLPPEANLSLDSSEG---ILARAVVRATVEQLLTSGQPLLIFLEEAPGYPGPRL 300

  Fly   358 MPKG-GILSVIVNAFMDGSIPDALLVPVSVNYERLVDG--NFVREQKGEKKIPESFGKAISGIWK 419
            ...| ..|.::|.|...|.:|||.||||:..|:.:.|.  |...:     ..|.........|::
  Rat   301 SALGQAWLGLVVQAVQAGIVPDATLVPVATAYDLVPDAPCNMTHD-----LAPLGLWTGALAIFR 360

  Fly   420 ALKSNYG-----LMRIDFNEPYSIRELVNSYNKIAREDGNIAKVYKPSARVLQH----------- 468
            .|.:.:|     .:|:...:|:|::|    |...||....       |.:.|:|
  Rat   361 RLCNCWGCNRRVCVRVHLAQPFSLQE----YTINARSCWG-------SRQTLEHLLQPIVLGECS 414

  Fly   469 -----------NQSTSSLYGTDVVCEEHRNLIESISRQVVFDCAAATSVMSTNALAFLLLTRFRN 522
                       ...||.|.   .:.||.:.|:..:||.|:....|:::||||..:|.|||.:.:.
  Rat   415 VVPDTEKEQEWTPPTSLLL---ALKEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKHQK 476

  Fly   523 GAEEQILSEALDDL----RNSLSGCKDIGFSGESSQIVAYACDLLGSGLVTRSRDENGRLVIKAV 583
            |.   :||:.|.:.    ..:|....|:||||:...:..:...||.:.:|. .|...|.||: ..
  Rat   477 GV---VLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVL-LRVHQGDLVV-VP 536

  Fly   584 NSVESFIELAYYSNMLTPHF---------------------------ALSSILLTTFHSLL---- 617
            ........||..|..|.|.|                           .|.|:.......||
  Rat   537 RPGPGLTHLARLSMELLPTFLSEAVGGESVGSAGLGCMWGRGKGPLLMLPSLPACAVRGLLAGRV 601

  Fly   618 -PE--TENKKEAAVSRKKLIDTALENCQIYRYEFILNKPTQVLENLLYQQLDDLLISGCVLTEKL 679
             ||  .|.:....:|:.:|....|....:...:.:|.:|.|.......:.||.|:..|.::.|:.
  Rat   602 PPEGPWELQGIELLSQNELYRQILLLLHLLPQDLLLPQPCQSSYCYCQEVLDRLIQCGLLVAEET 666

  Fly   680 HDDLPNGAEGRRLANVLAECLDEDGYEDVRDGEAD---EP-----KLLFASETPSQQRYICEVLA 736
            ....|....||:  ::.|:.|.:.. .|..|.|:|   ||     :|...|..|....::|.:|:
  Rat   667 PGSRPACDTGRQ--HLSAKLLWKPS-GDFTDSESDDFEEPGGRCFRLSQQSRCPDFFLFLCRLLS 728

  Fly   737 PFAWTYVTVAQSLQILHKNSMLESE 761
            |....:   ||:...||...:.:||
  Rat   729 PILKAF---AQAATFLHLGQLPDSE 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	158/684 (23%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	56/222 (25%)
Gpat2	XP_017447069.1	LPLAT_DHAPAT-like	176..387	CDD:153255	56/224 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45278
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12563
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.810