DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and Gpat2

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_006499195.3	Gene:	Gpat2 / 215456	MGIID:	2684962	Length:	829	Species:	Mus musculus

Alignment Length:	780	Identity:	185/780 - (23%)
Similarity:	314/780 - (40%)	Gaps:	148/780 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TLRSSNEPKTQNSVAHGIGTQNML----------ELTPHSGQ-KPF------------------K 107
            |:..|| |:||....|. |.:..|          .:||..|: :||                  :
Mouse    30 TMLKSN-PQTQQRSNHN-GQETSLWSSSFGMKMEAITPFLGKYRPFMGRCCQTCTPKSWESLFHR 92

  Fly   108 KLFDWGVLFPYVAQVVRSEKFEYR--QVTEIVHNDAVLKHAIKQA--AEQTLREQRYAKNGHRLL 168
            .:.|.|  |..|. :|:.|...:|  .|..:.:....|:..|..:  |.|.:.|....:|   ||
Mouse    93 SIMDLG--FCNVI-LVKEENTRFRGWLVRRLCYFLWSLEQHIPTSFDASQKIMENTGVQN---LL 151

  Fly   169 T---RSASGDQEAQEEEDEKRGISYQAILRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPC 230
            :   ..|:|:.:|.|            :::|:.||   ||..:.:|....||...||.|...|..
Mouse   152 SGRVPGAAGEGQAPE------------LVKKEVQR---ILGHIQTTPRPFLLRLFSWALLWFLNR 201

  Fly   231 FLSGVVTNTKQIEMLKTATERSPGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIP 295
            ....|..:..|::|::.|.:.. |:||:|:..|:|.||..::.::|.:..:....||..:....|
Mouse   202 LFLNVQLHKGQMKMVQKAVQEQ-GSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSP 265

  Fly   296 VFGGLLRGLGAFFIKRKID-PVEGKKDVLYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPCMP 359
            ....|||.||..|:..::: .::..:.:|.||.:...:...|..|..:..|:|......|.....
Mouse   266 ALRALLRKLGGLFLPPEVNLSLDNSEGILARAVVRATVEELLTSGQPLLIFLEEPPGSPGPRLSA 330

  Fly   360 KG-GILSVIVNAFMDGSIPDALLVPVSVNYERLVDGNFVREQKGEKKIPESFGKAIS--GIW--- 418
            .| ..|.|::.|...|.|.||.||||::.|:.:.|.            |.:....::  |:|
Mouse   331 LGQAWLGVVIQAVQAGIISDATLVPVAIAYDLVPDA------------PCNMNHDLAPLGLWTGA 383

  Fly   419 ----KALKSNYG-----LMRIDFNEPYSIRELVNSYNKIAREDGNIAKVYKPSARVLQHNQSTSS 474
                :.|.:.:|     .:|:...:|:|::|    |...||...:       |.:.|:|......
Mouse   384 LAVFRRLCNCWGCNRRVCVRVHLAQPFSLQE----YTINARSCWD-------SRQTLEHLLQPIV 437

  Fly   475 LYGTDVV-------------------CEEHRNLIESISRQVVFDCAAATSVMSTNALAFLLLTRF 520
            |....||                   .||.:.|:..:||.|:....|:::||||..:|.|||.:.
Mouse   438 LGECSVVPDTEKEQEWTPPTGLLLALKEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKH 502

  Fly   521 RNGAEEQILSEALDDL----RNSLSGCKDIGFSGESSQIVAYACDLLGSGLVTRSRDENGRLVIK 581
            :.|.   :||:.|.:.    ..:|....|:||||:...:..:...||.:.:|. .|...|.||:
Mouse   503 QKGV---VLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVL-LRVHQGDLVV- 562

  Fly   582 AVNSVESFIELAYYSNMLTPHFALSSILLTTFHSLL-----PE--TENKKEAAVSRKKLIDTALE 639
            ..........||..|..|.|.|...::.......||     ||  .|.:....:|:.:|....|.
Mouse   563 VPRPGPGLTHLARLSMELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGIELLSQNELYRQILL 627

  Fly   640 NCQIYRYEFILNKPTQVLENLLYQQLDDLLISGCVLTEKLHDDLPNGAEGRRLANVLAECLDEDG 704
            ...:...:.:|.:|.|.......:.||.|:..|.::.|:.....|....||:  ::.|:.|.:..
Mouse   628 LLHLLPQDLLLPQPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQ--HLSAKLLWKPS 690

  Fly   705 YEDVRDGEAD---EP-----KLLFASETPSQQRYICEVLAPFAWTYVTVAQSLQILHKNSMLESE 761
             .|..|.|:|   ||     :|...|..|....::|.:|:|....:   ||:...||...:.:||
Mouse   691 -GDFTDSESDDFEEPGGRCFRLSQQSRCPDFFLFLCRLLSPILKAF---AQAATFLHLGQLPDSE 751

Fly 762 761
Mouse 752 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	154/659 (23%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	53/226 (23%)
Gpat2	XP_006499195.3	LPLAT_DHAPAT-like	203..415	CDD:153255	53/228 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849900
Domainoid	1	1.000	130	1.000	Domainoid score	I5182
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43205
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12563
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5880
SonicParanoid	1	1.000	-	-		X2244
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.830