DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and acl-6

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001023769.1	Gene:	acl-6 / 178928	WormBaseID:	WBGene00017261	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	814	Identity:	201/814 - (24%)
Similarity:	354/814 - (43%)	Gaps:	203/814 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IRSDLLVTLRSSNE---PKTQNSVAHGIGTQNMLELTPHSG---------QKPFKKLFDWGVLFP 117
            :.|..:..|||..|   |..:..|.......::||.:..:|         :||.:.|.|
Worm     5 VESTSITQLRSHCETCFPLMEEVVPRRERYVDLLEFSNFNGIPYPVVDPSRKPRRFLAD------ 63

  Fly   118 YVAQVVRSEKFEYRQVTEIVHN-DAVLKHAIKQAAEQTLREQRYAKNGHRLLTRSASGDQEAQEE 181
                      |.|.....::|: ..|.|..:.            :|..||::::       .:|:
Worm    64 ----------FRYSWSIPLIHHYPNVEKDVLS------------SKRVHRVISK-------LKEQ 99

  Fly   182 EDEKRGISYQAILRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNTKQIEMLK 246
            .||            |:.||:....::.:.|:..:....|::|||:....:..::...:::|:|.
Worm   100 NDE------------QKNRAVQFFTEISARLSKFICKCCSYVLYKVFRRLMDKLLVCKEEMEVLY 152

  Fly   247 TATERSPGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKR 311
            .|.:  .|.|::::|||||||||:::||...:..::.|.:|:|:||.:...|.|||..|||||:|
Worm   153 EAEQ--TGIPMVYLPLHRSHLDYLLITWCNWHFGLKLPHIASGDNLNLSGLGWLLRATGAFFIRR 215

  Fly   312 KIDPVEGK-KDVLYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAFMDGS 375
            ::||.:.: ||.||||.||.|:...|.:...:|||:||.|:|.||...||.|::|.:|.|...|.
Worm   216 RVDPDDERGKDQLYRAILHSYIEQVLSKDMPIEFFLEGTRSRFGKALTPKNGLISNVVEAVQHGF 280

  Fly   376 IPDALLVPVSVNYERLVDGNFVREQKGEKKIPESFGKAISGIWKALKSNY------GLMRIDFNE 434
            |.|..|||||..|:.:|:|.|:.|..|..|:.||    :.|:::.:.|.:      |::|:.:..
Worm   281 IKDCYLVPVSYTYDAVVEGIFLHELMGIPKVRES----VLGVFRGIFSGFSKSKQCGVVRMHYGR 341

  Fly   435 PYSIRELVNSYNKIAREDGNIAKVYKPSARVLQHNQSTSSLY-------GTDVVCEEHRNLIESI 492
            |..:.|.      :|....:::..:: :..|.....|||..|       .|.....:.|.:|.:|
Worm   342 PIRLTEY------LATITASLSSNHR-TRPVRMTKLSTSFSYRELVPWHRTHSETVDDRTMIRAI 399

  Fly   493 SRQVVFDCAAATSVMSTNALAFLLLTRFRNGAE------------EQILSEALDDLRNSLSGCKD 545
            ...||::.....|:.....::.|||.::|....            |:|::|          |...
Worm   400 GFHVVYEAQMMCSISPVAVVSCLLLAKWRGKVSRSTFERDCEWLCEKIIAE----------GGDV 454

  Fly   546 IGFSG---ESSQIVAYACDLLGSGL-VTRSRDENGRLVIKAVNSVESFIELAYYSNMLTPHFALS 606
            :|:..   :.|.:|.||.:.|.|.: ||   ||    .:....|..|||.|||..|.:...|::.
Worm   455 VGYQSKKTKGSALVKYAFEKLESCVEVT---DE----YVSPKESHSSFITLAYNKNSVICRFSIK 512

  Fly   607 SILLTTFHSLLPETENKKEAAVSRKKLIDTALENCQIYRYEFILNKPTQVLENLLYQQLDDLLIS 671
            |::..|..|....|:      :|..::::.||..|...::||:..:|...|..|::.
Worm   513 SVIALTIVSRPSGTK------LSIDQIVEDALSLCDWLQFEFMFCRPCDSLRELVHN-------- 563

  Fly   672 GCVLTEKLHDDLPNGAEGRRLANVLAECLDEDGYED-----------VRDGEADEPKLLFASETP 725
              ||.:|...|..:|        .|...:::||:.|           |||.::.|....||:
Worm   564 --VLGQKEWSDPIHG--------FLRSEIEDDGFLDAGGALNSGTLRVRDAKSRETLQFFAN--- 615

  Fly   726 SQQRYICEVLAPFAWTYVTVAQSLQILHKNSMLESEFISFVIND-------LSSKVKRGSCIYA- 782
                    ::.||       .|||.::.          |||:::       ..:.:.|..|..:
Worm   616 --------LVRPF-------VQSLYLIS----------SFVVSEKCPTEPTSDNNIIRQLCQQSL 655

  Fly   783 ------------ESISTDSVRNCLKLLEKWSVIE 804
                        |||::||.:|.|::|:...:::
Worm   656 AGDIDLPFAPLLESINSDSFKNALRVLKDKGLLQ 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	165/627 (26%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	81/217 (37%)
acl-6	NP_001023769.1	PlsB	<58..688	CDD:225488	189/758 (25%)
acl-6	NP_001023769.1	LPLAT_DHAPAT-like	138..350	CDD:153255	81/223 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167109
Domainoid	1	1.000	133	1.000	Domainoid score	I3151
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7343
Inparanoid	1	1.050	207	1.000	Inparanoid score	I2413
Isobase	1	0.950	-	0	Normalized mean entropy	S6358
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	1	1.000	-	-		FOG0006866
OrthoInspector	1	1.000	-	-		oto20465
orthoMCL	1	0.900	-	-		OOG6_108110
Panther	1	1.100	-	-	LDO	PTHR12563
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5880
SonicParanoid	1	1.000	-	-		X2244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880