DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and GPAT2

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_001308454.1	Gene:	GPAT2 / 150763	HGNCID:	27168	Length:	801	Species:	Homo sapiens

Alignment Length:	785	Identity:	175/785 - (22%)
Similarity:	305/785 - (38%)	Gaps:	172/785 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RSSNEPKTQNSVAHGIGTQNMLE-LTPHSGQKPFKKLFDWGVLFPYVAQVVRS------EKFEYR 131
            |||...:..:..:.|.|.:  || :||..|:           ..|:|.:..::      |...:|
Human    14 RSSPSGREASLWSSGFGMK--LEAVTPFLGK-----------YRPFVGRCCQTCTPKSWESLFHR 65

  Fly   132 QVTEIVHNDAVLKHAIK----------------------------QAAEQTLREQRYAKNGHRLL 168
            .:|::...:.:|   :|                            |...|.:.|....:|   ||
Human    66 SITDLGFCNVIL---VKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDVPQKIMESTGVQN---LL 124

  Fly   169 T-RSASGDQEAQEEEDEKRGISYQAILRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCFL 232
            : |...|..|.|..:          :::|:.||   ||..:.:.....|:...||.|.:.|.|..
Human   125 SGRVPGGTGEGQVPD----------LVKKEVQR---ILGHIQAPPRPFLVRLFSWALLRFLNCLF 176

  Fly   233 SGVVTNTKQIEMLKTATERSPGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNNLQIPVF 297
            ..|..:..|::|::.|.:  .|.||:.:..|::.||.|::.::|.:..:....||..:....|..
Human   177 LNVQLHKGQMKMVQKAAQ--AGLPLVLLSTHKTLLDGILLPFMLLSQGLGVLRVAWDSRACSPAL 239

  Fly   298 GGLLRGLGAFFI----KRKIDPVEGKKDVLYRAALHLYLTHALKQGHNVEFFIEGGRTRTGKPCM 358
            ..|||.||..|:    ...:|..||   :|.||.:...:...|..|..:..|:|          .
Human   240 RALLRKLGGLFLPPEASLSLDSSEG---LLARAVVQAVIEQLLVSGQPLLIFLE----------E 291

  Fly   359 PKGGI-----------LSVIVNAFMDGSIPDALLVPVSVNYERLVDGNFVREQKGEKKIPESFGK 412
            |.|.:           :..:|.|...|.:||||||||:|.|:.:.|.            |.....
Human   292 PPGALGPRLSALGQAWVGFVVQAVQVGIVPDALLVPVAVTYDLVPDA------------PCDIDH 344

  Fly   413 AIS--GIW-------KALKSNYG-----LMRIDFNEPYSIRELVNSYNKIAREDGNIAKVYKP-- 461
            |.:  |:|       ::|.|.:|     ..|:...:|:|::|.:.|..........:.::.:|
Human   345 ASAPLGLWTGALAVLRSLWSRWGCSHRICSRVHLAQPFSLQEYIVSARSCWGGRQTLEQLLQPIV 409

  Fly   462 -----SARVLQHNQSTSSLYGTDVVC-EEHRNLIESISRQVVFDCAAATSVMSTNALAFLLLTRF 520
                 :....:..|..:.:.|..:.. ||.:.|:..:|..|:.....:::||||..:|.|||.:.
Human   410 LGQCTAVPDTEKEQEWTPITGPLLALKEEDQLLVRRLSCHVLSASVGSSAVMSTAIMATLLLFKH 474

  Fly   521 RNGAEEQILSEALDD---------LRNSLSGCKDIGFSGESSQIVAYACDLLGSGLVTRSRDENG 576
            :.|.   .||:.|.:         ||..     |:||||:...::.::..||.:. |...|...|
Human   475 QKGV---FLSQLLGEFSWLTEEILLRGF-----DVGFSGQLRSLLQHSLSLLRAH-VALLRIRQG 530

  Fly   577 RLVIKAVNSVESFIELAYYSNMLTPHFALSSILLTTFHSLL-----PE--TENKKEAAVSRKKLI 634
            .|:: ..........||..|..|.|.|...::.......||     |:  .|.:....:|:.:|.
Human   531 DLLV-VPQPGPGLTHLAQLSAELLPVFLSEAVGACAVRGLLAGRVPPQGPWELQGILLLSQNELY 594

  Fly   635 DTALENCQIYRYEFILNKPTQVLENLLYQQLDDLLISGCVLTEKLHDDLPNGAEGR-RLANVL-- 696
            ...|....:...:.:|.||.|.......:.||.|:..|.::.|:.....|....|| ||:..|
Human   595 RQILLLMHLLPQDLLLLKPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQRLSRKLLW 659

  Fly   697 ---AECLDEDGYEDVRDGEADEP--KLLFASETPSQQRYICEVLAPFAWTYVTVAQSLQILHKNS 756
               .:..|.|. :|.  ||||..  :|...|..|....::|.:|:|....:   ||:...|.:..
Human   660 KPSGDFTDSDS-DDF--GEADGRYFRLSQQSHCPDFFLFLCRLLSPLLKAF---AQAAAFLRQGQ 718

  Fly   757 MLESE 761
            :.::|
Human   719 LPDTE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	143/664 (22%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	58/239 (24%)
GPAT2	NP_001308454.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/6 (50%)
		LPLAT_DHAPAT-like	176..388	CDD:153255	58/238 (24%)
		Acyltransferase	180..331		43/165 (26%)
		HXXXXD motif	205..210		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159527
Domainoid	1	1.000	138	1.000	Domainoid score	I4850
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41136
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12563
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5880
SonicParanoid	1	1.000	-	-		X2244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.940