DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and Gnpat

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	NP_034452.3	Gene:	Gnpat / 14712	MGIID:	1343460	Length:	678	Species:	Mus musculus

Alignment Length:	714	Identity:	162/714 - (22%)
Similarity:	293/714 - (41%)	Gaps:	171/714 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 YRQVT--------EIVHNDAVLKHAIKQAAEQTLREQRYAKNGHRLLTRSASGDQEAQEEEDEKR 186
            ||.:|        .||.:...:.:.|||.:.::|                 :|....:||..|
Mouse    59 YRGITPCKPGDIKSIVLSSEEINYVIKQLSRESL-----------------TGVDVLREEASE-- 104

  Fly   187 GISYQAILRKQEQRAISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNTKQIEMLKTATER 251
                             ||::|...|..|.:.|.:::|.|:.....|.|..|.:.|:.|:.|.:.
Mouse   105 -----------------ILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNEEGIQKLQRAVQE 152

  Fly   252 SPGTPLIFVPLHRSHLDYIMVTWILTNNDIRSPLVAAGNN-LQIPVFGGLLRGLGAFFIKRKIDP 315
            .   |::.:|.|||::|::|:::||.:.|:..|::|||.: |.:.|...|||..||||::|...
Mouse   153 H---PVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFG- 213

  Fly   316 VEGKKDVLYRAALHLYLTHALKQGH-NVEFFIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDA 379
              |.|  ||.|....|:...|:.|: .||||:||.|:|..|...||.|:|::::..|....:.|.
Mouse   214 --GNK--LYWAVFSEYVKTMLRCGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDT 274

  Fly   380 LLVPVSVNYERLVDGN-FVREQKGEKKIPESFGKAISGIWKA---LKSNYGLMRIDFNEPYSIRE 440
            ..||:|::|:::::.: :..|..|..|..||    .:|:.||   |..|:|.:.:.|.:|.|:|.
Mouse   275 YFVPISISYDKILEESLYAYEILGVPKPKES----TTGLLKARRILSENFGSIHVYFGDPVSLRS 335

  Fly   441 LV------NSYNKIAREDGNIAKVYKPSARVLQHNQSTSSLYGTDVVCEEHRNLIESISRQVVFD 499
            |.      |:||.:.|             .:.|........:.|:|..:.....||:::   :..
Mouse   336 LAAGRLNRNTYNLVPR-------------CIPQKQPEDVQAFVTEVAYKMQLLQIENLA---LSP 384

  Fly   500 CAAATSVMSTNALAFLLLTRFRNGAEEQILSEALDDLRNSLSGCKDI--GF----SGESSQIVAY 558
            .....:::..|.|:...              :||.:....|.|...:  ||    ..:..:.|..
Mouse   385 WLLVVTILLQNQLSMDF--------------DALVEKTLWLKGVTQVFGGFLLWPDNKLPEEVVQ 435

  Fly   559 ACDLLGSGLVTRSRDENGRLVIKAVNSVES------------FIELAYYSNMLTPHFALSSILLT 611
            :..||.|.|.:..:|:    |:..:||..|            .:..:.|.|.|...||..|::..
Mouse   436 SSILLHSNLASLVKDQ----VVLKMNSGSSQVVNGLVPEHIALLMCSAYRNQLLNIFARPSLVAL 496

  Fly   612 TFHSLLPETENKKEAAVSRKKLIDTALENCQIYRYEFILNKPTQVLENLLYQQLDDLLISGCVLT 676
            ..| :.|..  :||...|    ..:.|.|  ::..|||. .|...|.:  :::       ||.|.
Mouse   497 ALH-MTPGL--RKEDVFS----CFSFLRN--VFSDEFIF-LPGNTLRD--FEE-------GCYLL 542

  Fly   677 EKLHDDLPNGAEGRRLANVLAECLDEDGYEDVRDGEADEPKLLFASETPSQQRYICEVLAPFAWT 741
            .|        ||..::|.              :|       ::...:..:..:::..:..||..:
Mouse   543 CK--------AEAMQMAG--------------KD-------IILTDKGTAVLQFLTSLFKPFVES 578

  Fly   742 YVTVAQSLQILHKNSML-ESEFISFVINDLSSKVKRGSCIYAESISTDSVRNCLKLLEKWSVIE 804
            |..:.:.|  ||:.... |.|::..........:.:||....:::|::..:|.|....:..|:|
Mouse   579 YQLLCRYL--LHEEDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKNALAAFVRLGVVE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	136/557 (24%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	73/222 (33%)
Gnpat	NP_034452.3	LPLAT_DHAPAT-like	133..338	CDD:153255	73/216 (34%)
		HXXXXD motif	161..166		3/4 (75%)
		Microbody targeting signal. /evidence=ECO:0000255	676..678
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820