DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mino and gpam

DIOPT Version :9

Sequence 1:	NP_001247343.2	Gene:	mino / 43350	FlyBaseID:	FBgn0027579	Length:	850	Species:	Drosophila melanogaster
Sequence 2:	XP_009305069.1	Gene:	gpam / 100332911	ZFINID:	ZDB-GENE-101026-1	Length:	826	Species:	Danio rerio

Alignment Length:	789	Identity:	222/789 - (28%)
Similarity:	409/789 - (51%)	Gaps:	71/789 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 PKTQ----NSVAHGIGTQNMLEL----TPHSGQKPFKKLFDWGVLFPYVAQVVRSEKFEYRQVTE 135
            |::|    |.....:|.:|::.:    |.|.|....:..:   ||| .:.:.|:.:.|. |.|.|
Zfish    70 PQSQDRLFNPSIPSLGLRNVIYINETHTRHRGWLARRLSY---VLF-VLERDVQKDMFA-RNVVE 129

  Fly   136 IVHNDAVLKHAIKQAAEQTLREQRYAKNGHRLLTRSASGDQEAQEEEDEKRGISYQAILRKQEQR 200
            .|.|::.|:.||.:.|.:.:                         :||.:.|:..:|: .|..::
Zfish   130 NVLNNSRLECAIVEVANEGV-------------------------QEDAEPGVDPKAV-SKVRRK 168

  Fly   201 AISILKDMGSTLNNGLLAFTSWILYKLLPCFLSGVVTNTKQIEMLKTATERSPGTPLIFVPLHRS 265
            |...|::|.:.::..|:..|.|:|.||...|...:..:..|:||:|.|.... ..||:|:|:|:|
Zfish   169 ARGWLQEMVANISPALIRLTGWVLLKLFNGFFWSIQIHKGQLEMVKKAASEY-NAPLVFLPVHKS 232

  Fly   266 HLDYIMVTWILTNNDIRSPLVAAGNNLQIPVFGGLLRGLGAFFIKRKIDPV-EGKKDVLYRAALH 329
            |:||:::|:||..::|::|.:||||||.||:...|:|.||.|||:||:|.. :||||||||:.||
Zfish   233 HIDYLLITFILFCHNIKAPHIAAGNNLNIPILSTLIRKLGGFFIRRKMDETSDGKKDVLYRSLLH 297

  Fly   330 LYLTHALKQGHNVEFFIEGGRTRTGKPCMPKGGILSVIVNAFMDGSIPDALLVPVSVNYERLVDG 394
            .|....|:|...:|.::||.|:|:|||...:.|:||::|:.....:|||.|:|||.::|:|:::|
Zfish   298 AYTEELLRQQQFLEVYLEGTRSRSGKPSPARAGMLSIVVDTLCASTIPDVLIVPVGISYDRIIEG 362

  Fly   395 NFVREQKGEKKIPESFGKAISGIWKALKSNYGLMRIDFNEPYSIRELVNSY-NKIAREDGNIAKV 458
            |:..||.|:.|..||......|:::.|:.|||.:|:||.:|:|::|.:::. ::..:....:.::
Zfish   363 NYNSEQLGKPKKNESLWGIACGVFRMLRKNYGCVRVDFTQPFSLKEYLDTQRSRHLQASLTLEQI 427

  Fly   459 YKPSARVLQHNQS-----TSSLYGTDVVCEE-HRNLIESISRQVVFDCAAATSVMSTNALAFLLL 517
            ..|.....|.:|:     ..:...:|:..|. .|.:|..:::.|:|..:.::::|||:.:|.|||
Zfish   428 LLPIIIATQPDQAVFNGENENHLNSDLSDEPWRRQVIADLAKHVLFSASKSSAIMSTHIVACLLL 492

  Fly   518 TRFRNGAEEQILSEALDDLRNS----LSGCKDIGFSGESSQIVAYACDLLGSGLVTRSRDENGRL 578
            .|.|.|.   :||:.::|..|.    ||...|:||||.|..:|.:|..|||:.:...|.::|...
Zfish   493 YRHRQGV---LLSKLVEDFFNMKEEILSRDFDLGFSGNSEDVVMHALSLLGNCVNVTSTNKNTEF 554

  Fly   579 VIKAVNSVESFIELAYYSNMLTPHFALSSILLTTFHSLLPE-------TENKKEAAVSRKKLIDT 636
            :|...|:|.:..||.:|||.|...|...:|:..:..:||.|       .:|.....:|:::||..
Zfish   555 IISPSNTVPALFELNFYSNGLFHVFIADAIIACSALALLREQTPASASEQNPSSTLLSQERLIRR 619

  Fly   637 ALENCQIYRYEFILNKPTQVLENLLYQQLDDLLISG-CVLTEKLHDDLPNGAE--GRRLANVLAE 698
            |.........|..:..|.|.|..:.:..:..|:..| .::.|:..::|....|  .::....|:.
Zfish   620 AAGLSHFLSNEVAVALPCQTLYQVFHDAITRLIEYGVLIVAEEDQEELSPSEEPWPKKFPEALSW 684

  Fly   699 CLDEDGYEDVRDGEADEPKLLFASETPSQQR---YICEVLAPFAWTYVTVAQSLQILHKNSMLES 760
            ..||:. ||...|:....:.|..|.:...|.   ::..:|.|....|...|..:..| .:.:.|.
Zfish   685 RSDEED-EDSDFGDEQRDRYLKVSPSAEHQEFYTFLQRILTPVLEAYSGAAIFIHSL-TSPISER 747

  Fly   761 EFISFVINDLSSKVKRGSCIYAESISTDSVRNCLKLLEKWSVIEVCNQQGMRLISLNTLYEMSRE 825
            ::...:...|.::.:||..:|.||.:...|:|.:|..::..|::...:.|:..:.|::.: :.:.
Zfish   748 DYTHQLFKYLLTRTERGVSMYGESATHYLVKNTVKTFKELGVLKERREDGVCRLELSSTF-IPQA 811

  Fly   826 SLNSIVKKI 834
            :.|.:::.|
Zfish   812 NKNKLLQYI 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mino	NP_001247343.2	PlsB	52..650	CDD:225488	185/597 (31%)
mino	NP_001247343.2	LPLAT_DHAPAT-like	232..443	CDD:153255	90/211 (43%)
gpam	XP_009305069.1	PlsB	<125..>599	CDD:225488	166/503 (33%)
gpam	XP_009305069.1	LPLAT_DHAPAT-like	200..411	CDD:153255	90/211 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595711
Domainoid	1	1.000	141	1.000	Domainoid score	I4671
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7343
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2623
OMA	1	1.010	-	-		QHG51484
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	1	1.000	-	-		FOG0006866
OrthoInspector	1	1.000	-	-		otm25196
orthoMCL	1	0.900	-	-		OOG6_108110
Panther	1	1.100	-	-	O	PTHR12563
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5880
SonicParanoid	1	1.000	-	-		X2244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940