DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12259 and FAM50A

DIOPT Version :9

Sequence 1:	NP_651595.1	Gene:	CG12259 / 43347	FlyBaseID:	FBgn0039557	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_004690.1	Gene:	FAM50A / 9130	HGNCID:	18786	Length:	339	Species:	Homo sapiens

Alignment Length:	355	Identity:	221/355 - (62%)
Similarity:	286/355 - (80%)	Gaps:	19/355 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAHYKGAASEAGRAAQLMKKREIQQQEIEFRKKKI-EEELKLDKIENKFATHYDAVEQQLKSSTI 64
            ||.|||||||||||..||||||.|::::|..|::| ||.:....|:.||:.||||||.:|||||:
Human     1 MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAELKSSTV 65

  Fly    65 GLVTLDEMKAKQEDIVREREKKLAQKKDEKDREKQRALEAIQAEKNKQ--KRQIQALSFNLDDDE 127
            |||||::||||||.:|:||||:||:|  |:.:|.|..||.::.::.|:  ||:|.:|||.|:::|
Human    66 GLVTLNDMKAKQEALVKEREKQLAKK--EQSKELQMKLEKLREKERKKEAKRKISSLSFTLEEEE 128

  Fly   128 EEEEEDDEDHDKKQLKIKQEDQPKPKWTEIKEDILPIKKKKICKNPDVDTSFLPDREREEQENRL 192
            |..||::|      ..:.:|        |::.:.:..||:|:.|||||||||||||:|||:||||
Human   129 EGGEEEEE------AAMYEE--------EMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRL 179

  Fly   193 REQLRQEWVMQQAELKDEDISITFSYWDGSGHRRNVLMKKGNSIYQFLQKCLELLRKEFIELKTV 257
            ||:|||||..:|.::|.|:|.|||||||||||||.|.|:|||::.|||||.||:|||:|.||::.
Human   180 REELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSELRSA 244

  Fly   258 MADQLMYVKEDLILPHHYSFYDFIVTKARGKSGPLFQFDVHDDVRMISDASVEKEESHAGKVLLR 322
            ..:||||:|||||:|||:||||||||||||||||||.||||||||::|||:|||:|||||||:||
Human   245 GVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDESHAGKVVLR 309

  Fly   323 SWYERNKHIFPASRWEPYDPTKSYDKYTIK 352
            ||||:|||||||||||||||.|.:|||||:
Human   310 SWYEKNKHIFPASRWEPYDPEKKWDKYTIR 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12259	NP_651595.1	XAP5	110..351	CDD:282738	156/242 (64%)
FAM50A	NP_004690.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		21/29 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..177		29/69 (42%)
		XAP5	<152..338	CDD:398536	141/185 (76%)
		Nuclear localization signal. /evidence=ECO:0000255	152..155		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	330	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_KOG2894
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3448
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1654
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55025
OrthoDB	1	1.010	-	-		D1061864at2759
OrthoFinder	1	1.000	-	-		FOG0003077
OrthoInspector	1	1.000	-	-		otm41519
orthoMCL	1	0.900	-	-		OOG6_102806
Panther	1	1.100	-	-	LDO	PTHR12722
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R430
SonicParanoid	1	1.000	-	-		X2051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870