DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12259 and fam50a

DIOPT Version :9

Sequence 1:	NP_651595.1	Gene:	CG12259 / 43347	FlyBaseID:	FBgn0039557	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001017636.1	Gene:	fam50a / 550329	ZFINID:	ZDB-GENE-050417-110	Length:	341	Species:	Danio rerio

Alignment Length:	362	Identity:	230/362 - (63%)
Similarity:	293/362 - (80%)	Gaps:	31/362 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAHYKGAASEAGRAAQLMKKREIQQQEIEFRKKKI-EEELKLDKIENKFATHYDAVEQQLKSSTI 64
            ||.|||||||||||.|||||||.:::::|..|:|| |:.:....|:.||:.|||||||:|||||:
Zfish     1 MAQYKGAASEAGRAMQLMKKREREREQLEQLKQKIAEDNMVKSNIDKKFSAHYDAVEQELKSSTV 65

  Fly    65 GLVTLDEMKAKQEDIVREREKKLAQK--------KDEKDREKQRALEAIQAEKNKQKRQIQALSF 121
            |||||::||||||.:|:||||:||:|        |.||.:||:|        |.:|||:|.:|||
Zfish    66 GLVTLNDMKAKQEALVKEREKQLAKKEQSKELQLKLEKQKEKKR--------KEEQKRKIASLSF 122

  Fly   122 NLDDDEEEEEEDDEDHDKKQLKIKQEDQPKPKWTEIKEDI-LPIKKKKICKNPDVDTSFLPDRER 185
            |.|:.|:||||::|:.:      ::||       ||:|:| ||:||||:.|||||||||||||:|
Zfish   123 NPDEGEDEEEEEEEEEE------EEED-------EIEEEICLPVKKKKLGKNPDVDTSFLPDRDR 174

  Fly   186 EEQENRLREQLRQEWVMQQAELKDEDISITFSYWDGSGHRRNVLMKKGNSIYQFLQKCLELLRKE 250
            ||:||||||:|||||..:|.::|.|:|.||||||||||||:.|.|||||:|.||||:.||:|||:
Zfish   175 EEEENRLREELRQEWERKQEKIKSEEIEITFSYWDGSGHRKTVKMKKGNTIQQFLQRALEVLRKD 239

  Fly   251 FIELKTVMADQLMYVKEDLILPHHYSFYDFIVTKARGKSGPLFQFDVHDDVRMISDASVEKEESH 315
            |.||::...:.|||:|||||:|||:||||||||||||||||||.||||||:|:::||:|||:|||
Zfish   240 FSELRSAGVEHLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDIRLVNDATVEKDESH 304

  Fly   316 AGKVLLRSWYERNKHIFPASRWEPYDPTKSYDKYTIK 352
            ||||:||||||:|||||||||||||||.|.:|||||:
Zfish   305 AGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12259	NP_651595.1	XAP5	110..351	CDD:282738	162/241 (67%)
fam50a	NP_001017636.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		20/25 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..147		34/87 (39%)
		XAP5	152..340	CDD:282738	140/187 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595212
Domainoid	1	1.000	346	1.000	Domainoid score	I1017
eggNOG	1	0.900	-	-		E1_KOG2894
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1529
OMA	1	1.010	-	-		QHG55025
OrthoDB	1	1.010	-	-		D1061864at2759
OrthoFinder	1	1.000	-	-		FOG0003077
OrthoInspector	1	1.000	-	-		oto40544
orthoMCL	1	0.900	-	-		OOG6_102806
Panther	1	1.100	-	-	LDO	PTHR12722
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R430
SonicParanoid	1	1.000	-	-		X2051
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800