DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12259 and Fam50b

DIOPT Version :9

Sequence 1:	NP_651595.1	Gene:	CG12259 / 43347	FlyBaseID:	FBgn0039557	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001100819.1	Gene:	Fam50b / 306883	RGDID:	1563458	Length:	335	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	204/353 - (57%)
Similarity:	268/353 - (75%)	Gaps:	19/353 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAHYKGAASEAGRAAQLMKKREIQQQEIEFRKKKI-EEELKLDKIENKFATHYDAVEQQLKSSTI 64
            ||.|||...|||||..|:||||.|::::|..|::| ||.:...|::.||:.||||||.:|||||:
  Rat     1 MAQYKGTMREAGRAMHLIKKREKQKEQMEVLKQRIAEETIMKSKVDKKFSAHYDAVEAELKSSTV 65

  Fly    65 GLVTLDEMKAKQEDIVREREKKLAQKKDEKDREKQRALEAIQAEKNKQKRQIQALSFNLDDDEEE 129
            |||||::||||||.::||||.:||:::..:.|..|..:...:..:.::||:|..|||.||
  Rat    66 GLVTLNDMKAKQEALLREREIQLAKREQLEQRRLQLEILREKERRRERKRKISNLSFTLD----- 125

  Fly   130 EEEDDEDHDKKQLKIKQEDQPKPKWTEIKEDILPIKKKKICKNPDVDTSFLPDREREEQENRLRE 194
             ||:|.|         |||..:.:..|:...   ..||.:.|||||||||||||||||:||||||
  Rat   126 -EEEDGD---------QEDGRQAEGAEVHSG---GAKKNLGKNPDVDTSFLPDREREEEENRLRE 177

  Fly   195 QLRQEWVMQQAELKDEDISITFSYWDGSGHRRNVLMKKGNSIYQFLQKCLELLRKEFIELKTVMA 259
            :|||||..::.::|.|::.|||||||||||||.|.|:||:::.|||::.|:.||::|.||:....
  Rat   178 ELRQEWEAKREKVKGEEVEITFSYWDGSGHRRTVRMRKGSTVQQFLKRALQGLRRDFRELRAAGV 242

  Fly   260 DQLMYVKEDLILPHHYSFYDFIVTKARGKSGPLFQFDVHDDVRMISDASVEKEESHAGKVLLRSW 324
            :|||||||||||||:::||||||.||||||||||.||||||||::|||::||:|||||||:||||
  Rat   243 EQLMYVKEDLILPHYHTFYDFIVAKARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSW 307

  Fly   325 YERNKHIFPASRWEPYDPTKSYDKYTIK 352
            ||:|||||||||||||||.|.:|||||:
  Rat   308 YEKNKHIFPASRWEPYDPEKKWDKYTIR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12259	NP_651595.1	XAP5	110..351	CDD:282738	148/240 (62%)
Fam50b	NP_001100819.1	XAP5	136..334	CDD:282738	133/200 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353157
Domainoid	1	1.000	334	1.000	Domainoid score	I1093
eggNOG	1	0.900	-	-		E1_KOG2894
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1576
OMA	1	1.010	-	-		QHG55025
OrthoDB	1	1.010	-	-		D1061864at2759
OrthoFinder	1	1.000	-	-		FOG0003077
OrthoInspector	1	1.000	-	-		otm45638
orthoMCL	1	0.900	-	-		OOG6_102806
Panther	1	1.100	-	-	O	PTHR12722
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770