DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Fbxl22

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_780415.1	Gene:	Fbxl22 / 74165	MGIID:	1921415	Length:	236	Species:	Mus musculus

Alignment Length:	204	Identity:	42/204 - (20%)
Similarity:	71/204 - (34%)	Gaps:	62/204 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 KLKDCSVRVGDTPKSIFYSIELHLLDLEDLSIED--------------NSWFEPYYIMGLSKLPS 248
            :||..:.|:....:|:  ||..|...::..||||              .|....:.:...::.|:
Mouse    53 ELKKDNFRLSPALRSL--SICWHSSRVQVCSIEDWLKSALQRSICSQHESLVNDFLLQVCNRCPN 115

  Fly   249 LRRLSLKGCQALCKFVPYGSMAARFGFQKLESLDLRQTPINNSDLQCFSAIENLKELLLESPQIL 313
            |..::|.||..:..                               .|      |..|||..|::.
Mouse   116 LTSVTLSGCGHVTD-------------------------------DC------LARLLLSCPRLR 143

  Fly   314 HSKQAVAKKNTNGNATDEAASPQPDSLKVLSDDE-PSTSRAAMEHLR-ACKVAFNLDNCSDRKEE 376
            ..:.....:.|  |.|..|.:....:|:.|..|. .:.|.|.:..|| ||.   ||...::|  .
Mouse   144 TLRLENCARVT--NRTLAAVAAHGRALQTLHVDFCRNVSAAGLLRLRAACP---NLRLSAER--S 201

  Fly   377 KSPVPTEPP 385
            .:.:|.:||
Mouse   202 AAMIPDQPP 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxl22	NP_780415.1	F-box-like	3..43	CDD:403981
		LRR 1	15..40
		LRR 2	43..72		6/20 (30%)
		AMN1	45..>200	CDD:187754	38/190 (20%)
		LRR 3	98..123		4/24 (17%)
		leucine-rich repeat	116..141	CDD:275381	9/61 (15%)
		LRR 4	124..149		7/61 (11%)
		leucine-rich repeat	142..167	CDD:275381	4/26 (15%)
		LRR 5	150..175		6/26 (23%)
		leucine-rich repeat	168..193	CDD:275381	9/27 (33%)
		LRR 6	176..201		9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030