DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and Fbxl2

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_848739.1	Gene:	Fbxl2 / 72179	MGIID:	1919429	Length:	423	Species:	Mus musculus

Alignment Length:	613	Identity:	118/613 - (19%)
Similarity:	182/613 - (29%)	Gaps:	254/613 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEILGRATEKTHTIK 139
            |||..||.:||..::......|..:..|.||...:..:||.|      ...::.||..|  :..|
Mouse    18 ELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFN------FQTDVEGRVVE--NISK 74

  Fly   140 ICGPPSSQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFPATLRRLKLKDCSV 204
            .||                                                 ..||:|.|:.| :
Mouse    75 RCG-------------------------------------------------GFLRKLSLRGC-I 89

  Fly   205 RVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSM 269
            .|||:....|                            .....::..|:|.||..:.....|.
Mouse    90 GVGDSSLKTF----------------------------AQNCRNIEHLNLNGCTKITDSTCYS-- 124

  Fly   270 AARFGFQKLESLDLRQ-TPINNSDLQCFS-AIENLKELLLE-SPQILHSKQAVAKKNTNGNATDE 331
            .:|| ..||:.|||.. ..:.||.|:..| ...||:.|.|. ..||  :|:.:           |
Mouse   125 LSRF-CSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQI--TKEGI-----------E 175

  Fly   332 AASPQPDSLKVL-------SDDEPSTSRAAMEHLR-ACK--VAFNLDNCSDRKEEKSPVPTEPPS 386
            |.......||.|       .:||      |::|:: .|.  |:.||.:||
Mouse   176 ALVRGCRGLKALLLRGCTQLEDE------ALKHIQNHCHELVSLNLQSCS--------------- 219

  Fly   387 EGQDLQAKRIRAPSESDDEDTSSTSGSSSDKLEVLSLPRNGHSN---AAPLSGGVDLPPLP--HA 446
                    ||     :||.......|  ..:|:.|.|  :|.||   |:..:.|::.|.|.  .|
Mouse   220 --------RI-----TDDGVVQICRG--CHRLQALCL--SGCSNLTDASLTALGLNCPRLQVLEA 267

  Fly   447 ADAANAADAPIAVDAANIEAPGQSPGLDPRPPRAYIYVPDAENANPRQQRSVVAVFAQGTEQRYI 511
            |..::..||...:.|.|...      |:.......:.:.|:
Mouse   268 ARCSHLTDAGFTLLARNCHE------LEKMDLEECVLITDS------------------------ 302

  Fly   512 YVNQQFSLPMNVLMPTRRHRTHPRPNYDQVVQHPMFWNMLEPLDRDYARRVRPRPPSCQTTPQYY 576
                                        .:||..:....|:.|...:          |:     .
Mouse   303 ----------------------------TLVQLSIHCPKLQALSLSH----------CE-----L 324

  Fly   577 VTDRAMYSFGRADRPVQPDVVWIRNINRSP--DNKLERLSLRNYHLITNHTLEHLVQCS--PNLV 637
            :||..                 |.:::.|.  ..:|..|.|.|..|:|:.:||||..|.  ..|.
Mouse   325 ITDEG-----------------ILHLSSSTCGHERLRVLELDNCLLVTDASLEHLENCRGLERLE 372

  Fly   638 YIDVSGTSITLPAIRRFKISKPKCEVVA 665
            ..|..  .:|...|:|.:...|..:|.|
Mouse   373 LYDCQ--QVTRAGIKRMRAQLPHVKVHA 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	11/38 (29%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	11/26 (42%)
Fbxl2	NP_848739.1	F-box-like	15..57	CDD:289689	11/38 (29%)
		leucine-rich repeat	52..79	CDD:275381	9/83 (11%)
		LRR 1	61..87		10/76 (13%)
		AMN1	<76..223	CDD:187754	51/274 (19%)
		leucine-rich repeat	80..99	CDD:275381	8/19 (42%)
		Interaction with Calmodulin. /evidence=ECO:0000269\|PubMed:21343341	80..90		5/10 (50%)
		LRR 2	88..113		7/53 (13%)
		leucine-rich repeat	106..131	CDD:275381	7/27 (26%)
		LRR 3	114..139		9/27 (33%)
		leucine-rich repeat	132..157	CDD:275381	8/24 (33%)
		LRR 4	140..165		8/24 (33%)
		leucine-rich repeat	158..183	CDD:275381	8/37 (22%)
		LRR 5	166..191		8/37 (22%)
		AMN1	168..367	CDD:187754	61/339 (18%)
		leucine-rich repeat	184..209	CDD:275381	8/30 (27%)
		LRR 6	192..217		8/30 (27%)
		leucine-rich repeat	210..235	CDD:275381	10/54 (19%)
		LRR 7	218..243		10/56 (18%)
		leucine-rich repeat	236..261	CDD:275381	8/26 (31%)
		LRR 8	244..269		7/24 (29%)
		leucine-rich repeat	262..287	CDD:275381	7/24 (29%)
		LRR 9	270..295		5/30 (17%)
		leucine-rich repeat	288..313	CDD:275381	4/76 (5%)
		LRR 10	296..321		5/76 (7%)
		leucine-rich repeat	314..336	CDD:275381	6/53 (11%)
		LRR 11	322..350		8/49 (16%)
		leucine-rich repeat	343..362	CDD:275381	8/18 (44%)
		LRR 12	351..375		8/23 (35%)
		LRR 13	376..401		6/25 (24%)
		CAAX motif	420..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850